2. Apoptosis
  3. Apoptosis
  4. C-DIM12

C-DIM12 

Cat. No.: HY-19808 Purity: 98.32%
COA Handling Instructions

C-DIM12 is a potent, orally active Nurr1 antagonist. C-DIM12 inhibits the tumor growth and autophagy, and induces the cell apoptosis. C-DIM12 has anti-inflammatory and neuroprotective effects, and can be used for cancer and neurological disease study.

For research use only. We do not sell to patients.

C-DIM12 Chemical Structure

C-DIM12 Chemical Structure

CAS No. : 178946-89-9

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Solid + Solvent
10 mM * 1 mL in DMSO
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10 mM * 1 mL in DMSO USD 55 In-stock
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10 mg USD 80 In-stock
25 mg USD 170 In-stock
50 mg USD 270 In-stock
100 mg USD 430 In-stock
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Customer Review

Based on 1 publication(s) in Google Scholar

C-DIM12 Related Antibodies

Top Publications Citing Use of Products

1 Publications Citing Use of MCE C-DIM12

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

C-DIM12 is a potent, orally active Nurr1 antagonist. C-DIM12 inhibits the tumor growth and autophagy, and induces the cell apoptosis. C-DIM12 has anti-inflammatory and neuroprotective effects, and can be used for cancer and neurological disease study[1][2][3].

In Vitro

C-DIM12 (15 μM, 3-5 day) increases cell proliferation and survival by inhibiting autophagy in MiaPaCa2 cells[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

C-DIM12 Related Antibodies
In Vivo

C-DIM12 (25 mg/kg for i.p., 14 day) modulates glial reactivity in MPTP-Induced Parkinsonism mice[2].
C-DIM12 (50-100 mg/kg for i.p., three times ) attenuates brain inflammation and improves functional recovery after intracerebral hemorrhage in mice[3].
C-DIM12 (30 mg/kg for i.p., 30 day) inhibits tumor growth and autophagy, and induces apoptosis in NURR1-KO cells orthotopic xenograft[1].
Pharmacokinetic Analysis in C57BL/6 male mice[1]

Route Organ Dose (mg/kg) Area under Curve (ng/mL*min) t1/2 (min) Cmax (ng/mL)
i.g. Plasma 25 539,220 249 1120
i.g. Brain 25 2,273,711 265 3622

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: MPTP-induced C57BL/6 male Parkinsonism mice [2]
Dosage: 25 mg/kg/day, 14day
Administration: Intragastric gavage (i.g.)
Result: Protected against the loss of DA neurons in the substantia nigra pars compacta and DA terminals in the striatum, maintained a ramified phenotype in microglia, and suppressed activation of astrocytes.
Animal Model: The ICR mice model of intracerebral hemorrhage induced by collagenase type VII[3]
Dosage: 50 and 100mg/kg/day at a 24-h interval, three times
Administration: Orally administration
Result: Improved the recovery of neurological function and prevented neuron loss in the hematoma, while suppressed activation of microglia/macrophages and expression of inflammatory mediators interleukin-6 and CC chemokine ligand 2.
Preserved axonal structures in the internal capsule and axonal transport function.
Decreased of iNOS mRNA expression.
Animal Model: MiaPaCa2 cells (Ctrl and NURR1-KO) orthotopic xenograft tumor models[1]
Dosage: 30 mg/kg, 30 day
Administration: Intraperitoneal injection (i.p.)
Result: Inhibited tumor growth and ATG7 and ATG12 mRNA levels, and induced apoptosis.
Molecular Weight

356.85

Appearance

Solid

Formula

C23H17ClN2
CAS No.
SMILES

ClC1=CC=C(C(C2=CNC3=C2C=CC=C3)C4=CNC5=C4C=CC=C5)C=C1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility
In Vitro: 

DMSO : ≥ 100 mg/mL (280.23 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.8023 mL 14.0115 mL 28.0230 mL
5 mM 0.5605 mL 2.8023 mL 5.6046 mL
10 mM 0.2802 mL 1.4011 mL 2.8023 mL
*Please refer to the solubility information to select the appropriate solvent.
Purity & Documentation
References
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C-DIM12 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

Keywords:

C-DIM12178946-89-9ApoptosisPancreatic ductal adenocarcinomaMiaPaCa2Parkinsonismintracerebral hemorrhageinflammationapoptosisautophagyInhibitorinhibitorinhibit

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