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C-DIM12 

Cat. No.: HY-19808 Purity: 98.04%
Data Sheet SDS Handling Instructions

C-DIM12 is a synthetic Nurr1 activaor induces Nurr1 and DA gene expression in cell lines and primary neurons.

For research use only. We do not sell to patients.
C-DIM12 Chemical Structure

C-DIM12 Chemical Structure

CAS No. : 178946-89-9

Size Price Stock Quantity
Free Sample (0.5-1 mg)   Apply now  
10 mM * 1 mL in DMSO $66 In-stock
5 mg $60 In-stock
10 mg $90 In-stock
25 mg $180 In-stock
50 mg $280 In-stock
100 mg $480 In-stock
200 mg $750 In-stock
500 mg   Get quote  
1 g   Get quote  

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Description

C-DIM12 is a synthetic Nurr1 activaor induces Nurr1 and DA gene expression in cell lines and primary neurons. Target: Nurr1 in vitro: C-DIM12 as a modulator of Nurr1 activity that results in inhibition of NF-κB-dependent gene expression in glial cells by stabilizing nuclear corepressor proteins, which reduces binding of p65 to inflammatory gene promoters. C-DIM12 Decreases Inflammatory Gene Expression in BV-2 Microglia. C-DIM12 Decreases Expression of NF-κB-Enhanced GFP Expression in Human Embryonic Kidney 293 Reporter Cells.[1] C-DIM12 increases protein levels of exogenously expressed human Nurr1 in transfected neurons.C-DIM12 protects neurons from 6-hydroxydopamine toxicity. [2]

References
Molecular Weight

356.85

Formula

C₂₃H₁₇ClN₂

CAS No.

178946-89-9

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Shipping

Room temperature in continental US; may vary elsewhere

Solvent & Solubility

10 mM in DMSO

* "<1 mg/mL" means slightly soluble or insoluble. "≥" means soluble, but saturation unknown.

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Product Name:
C-DIM12
Cat. No.:
HY-19808
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