1. GPCR/G Protein
    Neuronal Signaling
  2. Melanocortin Receptor
  3. RO27-3225 TFA

RO27-3225 TFA 

Cat. No.: HY-P2242A
Handling Instructions

RO27-3225 TFA is potent and selective melanocortin 4 receptor (MC4R) agonist with an EC50 of 1 nM and 8 nM for MC4R and MC1R, respectively. RO27-3225 TFA shows ~30-fold selectivity for MC4R over MC3R. RO27-3225 TFA has neuroprotective and anti-inflammatory effects.

For research use only. We do not sell to patients.

Custom Peptide Synthesis

RO27-3225 TFA Chemical Structure

RO27-3225 TFA Chemical Structure

Size Stock
100 mg   Get quote  
250 mg   Get quote  
500 mg   Get quote  

* Please select Quantity before adding items.

Top Publications Citing Use of Products
  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

RO27-3225 TFA is potent and selective melanocortin 4 receptor (MC4R) agonist with an EC50 of 1 nM and 8 nM for MC4R and MC1R, respectively. RO27-3225 TFA shows ~30-fold selectivity for MC4R over MC3R. RO27-3225 TFA has neuroprotective and anti-inflammatory effects[1][2][3].

IC50 & Target

EC50: 1 nM (Melanocortin 4 receptor (MC4R)), 8 nM (MC1R), 675 nM (MC3R) and 5779 nM (MC5R)[1]

In Vivo

RO27-3225 (0.012-0.048 mg/kg; intravenous injection; Wistar rats) treatment reverses haemorrhagic shock, reduces multiple organ damage and improves survival. RO27-3225 could have a protective role against multiple organ failure following circulatory shock[2].

Animal Model: Wistar rats of both sexes (270-300 g) with haemorrhagic shock[2]
Dosage: 0.012 mg/kg, 0.024 mg/kg, 0.048 mg/kg
Administration: Intravenous injection
Result: Reversed haemorrhagic shock, reduced multiple organ damage and improved survival.
Molecular Weight

898.93

Formula

C₄₁H₅₃F₃N₁₂O₈

Sequence

Oxobutyl-{His}{Phe}{Arg}{Trp}{Sar}-NH2

Sequence Shortening

Oxobutyl-HFRW-{Sar}-NH2

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
  • No file chosen (Maximum size is: 1024 Kb)
  • If you have published this work, please enter the PubMed ID.
  • Your name will appear on the site.
  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

Keywords:

RO27-3225Melanocortin ReceptorMC ReceptorMC4RMC1Ranti-inflammatoryauditoryfoodintakehemorrhagicshocksurvivalneuroprotectiveInhibitorinhibitorinhibit

Your Recently Viewed Products:

Inquiry Online

Your information is safe with us. * Required Fields.

Product name

 

Salutation

Applicant name *

 

Email address *

Phone number *

 

Organization name *

Country or Region *

 

Requested quantity *

Remarks

Bulk Inquiry

Inquiry Information

Product name:
RO27-3225 TFA
Cat. No.:
HY-P2242A
Quantity:
MCE Japan Authorized Agent: