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Cat. No.: HY-155518

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IRAK4-IN-25

IRAK4-IN-25 (compound 38) is an orally acitve and potent IRAK4 inhibitor (IC₅₀=7.3 nM), with low clearance (Cl=12 mL/min/kg). IRAK4-IN-25 inhibits production of pro-inflammatory cytokines, and shows in vitro safety and ADME profiles. IRAK4-IN-25 can be used for research in inflammatory and autoimmune disorders.

For research use only. We do not sell to patients.

CAS No.: 2952533-47-8
Formula: C₂₃H₂₅N₅O₄
Molecular Weight:435.48

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (267 KB)

IRAK4-IN-25 Chemical Structure

CAS No.: 2952533-47-8

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- Cellular Effect
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

IC₅₀ & Target

IRAK4^[1]

All IRAK Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
BMDM	IC₅₀	1204 nM Compound: 38	Inhibition of LPS-induced TNFalpha mRNA expression in immortalized mouse BMDM cells preincubated for 2 hrs followed by LPS stimulation and measured after 16 hrs by qPCR analysis Inhibition of LPS-induced TNFalpha mRNA expression in immortalized mouse BMDM cells preincubated for 2 hrs followed by LPS stimulation and measured after 16 hrs by qPCR analysis	[PMID: 37413880]
BMDM	IC₅₀	130.5 nM Compound: 38	Inhibition of LPS-induced IL-6 protein expression in immortalized mouse BMDM cells preincubated for 2 hrs followed by LPS stimulation and measured after 16 hrs by ELISA Inhibition of LPS-induced IL-6 protein expression in immortalized mouse BMDM cells preincubated for 2 hrs followed by LPS stimulation and measured after 16 hrs by ELISA	[PMID: 37413880]
BMDM	IC₅₀	214.3 nM Compound: 38	Inhibition of LPS-induced IL-6 mRNA expression in immortalized mouse BMDM cells preincubated for 2 hrs followed by LPS stimulation and measured after 16 hrs by qPCR analysis Inhibition of LPS-induced IL-6 mRNA expression in immortalized mouse BMDM cells preincubated for 2 hrs followed by LPS stimulation and measured after 16 hrs by qPCR analysis	[PMID: 37413880]
BMDM	IC₅₀	495.1 nM Compound: 38	Inhibition of LPS-induced TNFalpha protein expression in immortalized mouse BMDM cells preincubated for 2 hrs followed by LPS stimulation and measured after 16 hrs by ELISA Inhibition of LPS-induced TNFalpha protein expression in immortalized mouse BMDM cells preincubated for 2 hrs followed by LPS stimulation and measured after 16 hrs by ELISA	[PMID: 37413880]
PBMC	IC₅₀	54.07 nM Compound: 38	Inhibition of LPS-induced TNFalpha protein expression in human PBMC cells preincubated for 2 hrs followed by LPS stimulation and measured after 16 hrs by ELISA Inhibition of LPS-induced TNFalpha protein expression in human PBMC cells preincubated for 2 hrs followed by LPS stimulation and measured after 16 hrs by ELISA	[PMID: 37413880]
PBMC	IC₅₀	559.8 nM Compound: 38	Inhibition of LPS-induced IL-6 mRNA expression in human PBMC cells preincubated for 2 hrs followed by LPS stimulation and measured after 16 hrs by qPCR analysis Inhibition of LPS-induced IL-6 mRNA expression in human PBMC cells preincubated for 2 hrs followed by LPS stimulation and measured after 16 hrs by qPCR analysis	[PMID: 37413880]

Chemical Information

CAS No. 2952533-47-8
Molecular Weight 435.48
Formula C₂₃H₂₅N₅O₄
SMILES

O[C@@H]1C[C@H](OC2=NC3=C(C=C2C(NC4=CC=CC(C5=CN(C)N=C5)=N4)=O)CC(C)(C)O3)C1
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (267 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Hao Y, et al. Synthesis and evaluation of dihydrofuro [2, 3-b] pyridine derivatives as potent IRAK4 inhibitors[J]. European Journal of Medicinal Chemistry, 2023: 115616.

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Biological Activity
- Description
- IC₅₀ & Target
Chemical Information
Purity & Documentation
References

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IRAK4-IN-25

All IRAK Isoforms

Biological Activity

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

IRAK4-IN-25 Related Classifications

HY-155518 Related Classifications