IRAK4-IN-25
IRAK4-IN-25 (compound 38) is an orally acitve and potent IRAK4 inhibitor (IC50=7.3 nM), with low clearance (Cl=12 mL/min/kg). IRAK4-IN-25 inhibits production of pro-inflammatory cytokines, and shows in vitro safety and ADME profiles. IRAK4-IN-25 can be used for research in inflammatory and autoimmune disorders.
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- CAS. Nr.: 2952533-47-8
- Formel: C23H25N5O4
- Molecular Weight:435.48
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Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biologische Aktivität
Beschreibung
IC50 & Target
IRAK4[1]
Cellular Effect
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Cell Line
|
Type | Value | Description | References |
|---|---|---|---|---|
| BMDM | IC50 |
1204 nM
Compound: 38
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Inhibition of LPS-induced TNFalpha mRNA expression in immortalized mouse BMDM cells preincubated for 2 hrs followed by LPS stimulation and measured after 16 hrs by qPCR analysis
Inhibition of LPS-induced TNFalpha mRNA expression in immortalized mouse BMDM cells preincubated for 2 hrs followed by LPS stimulation and measured after 16 hrs by qPCR analysis
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[PMID: 37413880] |
| BMDM | IC50 |
130.5 nM
Compound: 38
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Inhibition of LPS-induced IL-6 protein expression in immortalized mouse BMDM cells preincubated for 2 hrs followed by LPS stimulation and measured after 16 hrs by ELISA
Inhibition of LPS-induced IL-6 protein expression in immortalized mouse BMDM cells preincubated for 2 hrs followed by LPS stimulation and measured after 16 hrs by ELISA
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[PMID: 37413880] |
| BMDM | IC50 |
214.3 nM
Compound: 38
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Inhibition of LPS-induced IL-6 mRNA expression in immortalized mouse BMDM cells preincubated for 2 hrs followed by LPS stimulation and measured after 16 hrs by qPCR analysis
Inhibition of LPS-induced IL-6 mRNA expression in immortalized mouse BMDM cells preincubated for 2 hrs followed by LPS stimulation and measured after 16 hrs by qPCR analysis
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[PMID: 37413880] |
| BMDM | IC50 |
495.1 nM
Compound: 38
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Inhibition of LPS-induced TNFalpha protein expression in immortalized mouse BMDM cells preincubated for 2 hrs followed by LPS stimulation and measured after 16 hrs by ELISA
Inhibition of LPS-induced TNFalpha protein expression in immortalized mouse BMDM cells preincubated for 2 hrs followed by LPS stimulation and measured after 16 hrs by ELISA
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[PMID: 37413880] |
| PBMC | IC50 |
54.07 nM
Compound: 38
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Inhibition of LPS-induced TNFalpha protein expression in human PBMC cells preincubated for 2 hrs followed by LPS stimulation and measured after 16 hrs by ELISA
Inhibition of LPS-induced TNFalpha protein expression in human PBMC cells preincubated for 2 hrs followed by LPS stimulation and measured after 16 hrs by ELISA
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[PMID: 37413880] |
| PBMC | IC50 |
559.8 nM
Compound: 38
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Inhibition of LPS-induced IL-6 mRNA expression in human PBMC cells preincubated for 2 hrs followed by LPS stimulation and measured after 16 hrs by qPCR analysis
Inhibition of LPS-induced IL-6 mRNA expression in human PBMC cells preincubated for 2 hrs followed by LPS stimulation and measured after 16 hrs by qPCR analysis
|
[PMID: 37413880] |
Chemical Information
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CAS. Nr. 2952533-47-8
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Molecular Weight 435.48
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Formel C23H25N5O4
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SMILES
O[C@@H]1C[C@H](OC2=NC3=C(C=C2C(NC4=CC=CC(C5=CN(C)N=C5)=N4)=O)CC(C)(C)O3)C1
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Reinheit & Dokumentation
Verweise
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
IRAK4-IN-25 Related Classifications
HY-155518 Related Classifications
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