2952533-47-8
2952533-47-8
Chemical Structure
IRAK4-IN-25
- CAS No.: 2952533-47-8
- Formula:C23H25N5O4
- Molecular Weight:435.48
InChIKey: ATVTUVKVZSYFBE-IYBDPMFKSA-N
SMILES: O[C@@H]1C[C@H](OC2=NC3=C(C=C2C(NC4=CC=CC(C5=CN(C)N=C5)=N4)=O)CC(C)(C)O3)C1
Biological Activity: IRAK4-IN-25 (compound 38) is an orally acitve and potent IRAK4 inhibitor (IC50=7.3 nM), with low clearance (Cl=12 mL/min/kg). IRAK4-IN-25 inhibits production of pro-inflammatory cytokines, and shows in vitro safety and ADME profiles. IRAK4-IN-25 can be used for research in inflammatory and autoimmune disorders[1].
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IRAK4-IN-25 | IRAK4-IN-25 (compound 38) is an orally acitve and potent IRAK4 inhibitor (IC50=7.3 nM), with low clearance (Cl=12 mL/min/kg). IRAK4-IN-25 inhibits production of pro-inflammatory cytokines, and shows in vitro safety and ADME profiles. IRAK4-IN-25 can be used for research in inflammatory and autoimmune disorders. | |||||||||||||||||||||
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References
Keywords
