2. Metabolic Enzyme/Protease Autophagy Anti-infection
  3. Phosphodiesterase (PDE) Autophagy HIV
  4. Pentoxifylline-d5

Pentoxifylline-d5  (Synonyms: BL-191-d5; PTX-d5; Oxpentifylline-d5)

Cat. No.: HY-B0715S2 Purity: 99.86%
COA Handling Instructions

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Pentoxifylline-d5 is the deuterium labeled Pentoxifylline. Pentoxifylline (BL-191), a haemorheological agent, is an orally active non-selective phosphodiesterase (PDE) inhibitor, with immune modulation, anti-inflammatory, hemorheological, anti-fibrinolytic and anti-proliferation effects. Pentoxifylline can be used for the research of peripheral vascular disease, cerebrovascular disease and a number of other conditions involving a defective regional microcirculation[1][2][3].

For research use only. We do not sell to patients.

Pentoxifylline-d<sub>5</sub> Chemical Structure

Pentoxifylline-d5 Chemical Structure

CAS No. : 1185995-18-9

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5 mg USD 120 In-stock
10 mg USD 190 In-stock
25 mg USD 410 In-stock
50 mg USD 650 In-stock
100 mg USD 1050 In-stock
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Based on 1 publication(s) in Google Scholar

Other Forms of Pentoxifylline-d5:

Pentoxifylline-d5 Related Antibodies

Top Publications Citing Use of Products

View All Phosphodiesterase (PDE) Isoform Specific Products:

View All Isoforms
PDE1 PDE2 PDE3 PDE4 PDE5 PDE6 PDE7 PDE9 PDE10 PDE11 PDE12 PDE8 Autotaxin

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  • Purity & Documentation

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Description

Pentoxifylline-d5 is the deuterium labeled Pentoxifylline. Pentoxifylline (BL-191), a haemorheological agent, is an orally active non-selective phosphodiesterase (PDE) inhibitor, with immune modulation, anti-inflammatory, hemorheological, anti-fibrinolytic and anti-proliferation effects. Pentoxifylline can be used for the research of peripheral vascular disease, cerebrovascular disease and a number of other conditions involving a defective regional microcirculation[1][2][3].

In Vitro

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Pentoxifylline-d5 Related Antibodies
Molecular Weight

283.34

Formula

C13H13D5N4O3
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C1C2=C(N=CN2C)N(C(N1CCCC([2H])([2H])C(C([2H])([2H])[2H])=O)=O)C
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : ≥ 100 mg/mL (352.93 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.5293 mL 17.6466 mL 35.2933 mL
5 mM 0.7059 mL 3.5293 mL 7.0587 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

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(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 3.5293 mL 17.6466 mL 35.2933 mL 88.2332 mL
5 mM 0.7059 mL 3.5293 mL 7.0587 mL 17.6466 mL
10 mM 0.3529 mL 1.7647 mL 3.5293 mL 8.8233 mL
15 mM 0.2353 mL 1.1764 mL 2.3529 mL 5.8822 mL
20 mM 0.1765 mL 0.8823 mL 1.7647 mL 4.4117 mL
25 mM 0.1412 mL 0.7059 mL 1.4117 mL 3.5293 mL
30 mM 0.1176 mL 0.5882 mL 1.1764 mL 2.9411 mL
40 mM 0.0882 mL 0.4412 mL 0.8823 mL 2.2058 mL
50 mM 0.0706 mL 0.3529 mL 0.7059 mL 1.7647 mL
60 mM 0.0588 mL 0.2941 mL 0.5882 mL 1.4706 mL
80 mM 0.0441 mL 0.2206 mL 0.4412 mL 1.1029 mL
100 mM 0.0353 mL 0.1765 mL 0.3529 mL 0.8823 mL
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Pentoxifylline-d5 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Pentoxifylline-d51185995-18-9BL-191-d5PTX-d5Oxpentifylline-d5Phosphodiesterase (PDE)AutophagyHIVHuman immunodeficiency virusInhibitorinhibitorinhibit

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