2. Immunology/Inflammation
  3. COX
  4. Cyclovalone

Cyclovalone (Beveno) is a synthetic curcumin derivate, which inihibits cyclooxygenase and exhibits anti-inflammatory, antitumor and antioxidant activities. Cyclovalone inhibits cell proliferation in normal and malignant prostatic cells. Cyclovalone ist orally active.

For research use only. We do not sell to patients.

Cyclovalone Chemical Structure

Cyclovalone Chemical Structure

CAS No. : 579-23-7

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Cyclovalone Related Antibodies

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Description

Cyclovalone (Beveno) is a synthetic curcumin derivate, which inihibits cyclooxygenase and exhibits anti-inflammatory, antitumor and antioxidant activities[1]. Cyclovalone inhibits cell proliferation in normal and malignant prostatic cells. Cyclovalone ist orally active[2].

In Vitro

Cyclovalone (0.2-10 μg/ml) inhibits proliferations of androgen-responsive LNCaP cells and androgen-independent PC-3 cells through interfere with cell cycle transition[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cyclovalone Related Antibodies

Cell Proliferation Assay[2]

Cell Line: LNCaP and PC-3 cells
Concentration: 0.2-10 μg/ml
Incubation Time: 2-9 days
Result: Inihibited cell proliferation in LNCaP and PC-3 cells in a time- and dose-dependent manner.

Cell Cycle Analysis[2]

Cell Line: LNCaP and PC-3 cells
Concentration: 2 μg/ml
Incubation Time: 72 h
Result: Decreased the numbers of LNCaP cells in G0/G1 phase, increased the numbers of cells in S-phase and G2/M phase.
Decreased the numbers of PC-3 cells in G0/G1 phase, increased the numbers of cells in S-phase.
In Vivo

Cyclovalone (9.5-38 mg/kg, p.o. for 14 days) ist a prostate specific antagonist without significant toxicity in BALB/c mice[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: BALB/c mice[2]
Dosage: 9.5-38 mg/kg/day
Administration: p.o. for 14 days
Result: Reduced weight of ventral prostate in a dose-dependent manner.
Animal Model: PC-3 xenografted athymic BALB/c nude mice[2]
Dosage: 38 mg/kg
Administration: p.o. for 20 days
Result: Inhibited tumor growth without toxicity.
Molecular Weight

366.41

Formula

C22H22O5
CAS No.
SMILES

O=C(/C(CCC/1)=C/C2=CC(OC)=C(O)C=C2)C1=C\C3=CC(OC)=C(O)C=C3
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Cyclovalone Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Cyclovalone579-23-7BevenoCOXCyclooxygenaseathymic nude miceLNCaPPC-3Inhibitorinhibitorinhibit

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