1. Membrane Transporter/Ion Channel
    Neuronal Signaling
  2. TRP Channel
  3. PF-04745637

PF-04745637 

Cat. No.: HY-120689
Handling Instructions

PF-04745637 is a potent and selective TRPA1 antagonist with an IC50 of 17 nM for human TRPA1.

For research use only. We do not sell to patients.

PF-04745637 Chemical Structure

PF-04745637 Chemical Structure

CAS No. : 1917294-46-2

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Description

PF-04745637 is a potent and selective TRPA1 antagonist with an IC50 of 17 nM for human TRPA1[1].

IC50 & Target[1]

TRPA1

17 nM (IC50)

In Vivo

Topically applied PF-04745637 (Compound 8; 50 mg/mL and 100 mg/mL) significantly reduces cinnamaldehyde-mediated flare in rat skin[1].

Molecular Weight

509.00

Formula

C₂₇H₃₂ClF₃N₂O₂

CAS No.

1917294-46-2

SMILES

O=C(C1(C2=CC=C(Cl)C=C2)CCCC1)NCC(N3CCC(C(F)(F)F)(O)CC3)CC4=CC=CC=C4

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
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Keywords:

PF-04745637PF04745637PF 04745637TRP ChannelTransient receptor potential channelsTRPA1inflammatoryboweldiseaseskinrespiratoryInhibitorinhibitorinhibit

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PF-04745637
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