1. Metabolic Enzyme/Protease
    Neuronal Signaling
    Membrane Transporter/Ion Channel
    GPCR/G Protein
    Anti-infection
  2. Phosphodiesterase (PDE)
    Calcium Channel
    Adrenergic Receptor
    Dopamine Receptor
    Influenza Virus
  3. Glaucine

Glaucine (Synonyms: O,O-Dimethylisoboldine; S-(+)-Glaucine; NSC 34396)

Cat. No.: HY-N3945
Handling Instructions

Glaucine (O,O-Dimethylisoboldine) is an alkaloid isolated from Glaucium flavum Crantz with antitussive, bronchodilation and anti-inflammatory properties. Glaucine is a selective and orally active phosphodiesterase 4 (PDE4) inhibitor with Kis of 3.4 µM in human bronchus and polymorphonuclear leukocytes. Glaucine is also a non-selective α-adrenoceptor antagonist, a Ca2+ entry blocker, and a weak dopamine D1 and D2 receptor antagonist. Glaucine has antioxidative and antiviral activities.

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Glaucine Chemical Structure

Glaucine Chemical Structure

CAS No. : 475-81-0

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Description

Glaucine (O,O-Dimethylisoboldine) is an alkaloid isolated from Glaucium flavum Crantz with antitussive, bronchodilation and anti-inflammatory properties. Glaucine is a selective and orally active phosphodiesterase 4 (PDE4) inhibitor with Kis of 3.4 µM in human bronchus and polymorphonuclear leukocytes. Glaucine is also a non-selective α-adrenoceptor antagonist, a Ca2+ entry blocker, and a weak dopamine D1 and D2 receptor antagonist. Glaucine has antioxidative and antiviral activities[1][2][3].

IC50 & Target

Ki: 3.4 µM (Phosphodiesterase 4 (PDE4))[1]
α-adrenoceptor[1]
Ca2+ channel[1]
Dopamine D1/D2 receptors[2]

Molecular Weight

355.43

Formula

C₂₁H₂₅NO₄

CAS No.

475-81-0

SMILES

CN1CCC2=CC(OC)=C(OC)C3=C2[[email protected]]1([H])CC4=CC(OC)=C(OC)C=C34

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Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

GlaucineO,O-Dimethylisoboldine S-(+)-Glaucine NSC 34396NSC34396NSC 34396NSC-34396Phosphodiesterase (PDE)Calcium ChannelAdrenergic ReceptorDopamine ReceptorInfluenza VirusCa2+ channelsCa channelsBeta ReceptorPDE4Ca2+α-adrenoceptoralkaloidanti-arthriticantitussivebronchodilationcAMPanti-inflammatoryantioxidativeantiviralInhibitorinhibitorinhibit

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