Cinnamoyl- and hydroxycinnamoyl amides of glaucine and their antioxidative and antiviral activities

  • Bioorg Med Chem. 2008 Aug 1;16(15):7457-61. doi: 10.1016/j.bmc.2008.06.010.
Maya Spasova  1 ,  Stefan Philipov ,  L Nikolaeva-Glomb ,  A S Galabov ,  Ts Milkova
Affiliations
  • 1. South-West University, Neofit Rilski, Blagoevgrad 2700, Bulgaria.
PMID: 18590964 DOI: 10.1016/j.bmc.2008.06.010
Abstract

The aporphine alkaloid glaucine has been converted into 3-aminomethylglaucine and its free amino group has been linked to cinnamic, ferulic, sinapic, o-, and p-coumaric acids. The antioxidative potential of the synthesized amides was studied against DPPH(*) test. All of the tested compounds demonstrated higher radical scavenging activity than glaucine and 3-aminomethylglaucine, and lower antioxidative effect than the free hydroxycinnamic acids. The newly synthesized compounds were tested in vitro for Antiviral activity against viruses belonging to different taxonomic groups.

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