2. GPCR/G Protein
  3. PTHR
  4. Osteostatin

Osteostatin, a fragment of parathyroid hormone-related protein (PTHrP) 107-111, promotes bone repair in animal models of bone defects and prevents bone erosion in inflammatory arthritis, inhibits collagen-induced arthritis and inhibits osteoclastic bone resorption directly. Osteostatin can be used for inflammation and immunology research.

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Osteostatin Chemical Structure

Osteostatin Chemical Structure

CAS No. : 138949-73-2

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Osteostatin Related Antibodies

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Description

Osteostatin, a fragment of parathyroid hormone-related protein (PTHrP) 107-111, promotes bone repair in animal models of bone defects and prevents bone erosion in inflammatory arthritis, inhibits collagen-induced arthritis and inhibits osteoclastic bone resorption directly. Osteostatin can be used for inflammation and immunology research[1][2][3][4].

In Vitro

Osteostatin (100, 250 and 500 nM, 7-9 days) decreases the differentiation of osteoclasts in a concentration-dependent manner[2].
Osteostatin (100, 250 and 500 nM, 7 days) decreases the mRNA levels of cathepsin K, osteoclast associated Ig-like receptor (OSCAR) and NFATc1[2].
Osteostatin (100, 250 and 500 nM, 2 days) inhibits the nuclear translocation of the master transcription factor NFATc1 in osteoclast differentiation [2].
Osteostatin (0.1-100 nM, 2 days) significantly increased cell growth in MC3T3-E1 cells[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Osteostatin Related Antibodies

Cell Differentiation Assay[2]

Cell Line: PBMCs are cultured with M-CSF and RANKL
Concentration: 100, 250 and 500 nM
Incubation Time: 7-9 days
Result: Decreased the differentiation of osteoclasts in a concentration-dependent manner, but it does not modify the resorptive ability of mature osteoclasts.

RT-PCR[2]

Cell Line: PBMCs are cultured with M-CSF and RANKL
Concentration: 100, 250 and 500 nM
Incubation Time: 7 days
Result: Decreased the mRNA levels of cathepsin K, osteoclast associated Ig-like receptor (OSCAR) and NFATc1.

Immunofluorescence[2]

Cell Line: PBMCs are cultured with M-CSF and RANKL
Concentration: 100, 250 and 500 nM
Incubation Time: 2 days
Result: Inhibited the nuclear translocation of the master transcription factor in osteoclast differentiation NFATc1.

Cell Proliferation Assay[3]

Cell Line: MC3T3-E1 cells
Concentration: 0-100 nM
Incubation Time: 2 days
Result: Significantly increased cell growth of MC3T3-E1 cells
In Vivo

Osteostatin (80 or 120 μg/kg,; after the onset of disease s.c. every day for 13 days) decreases the severity of arthritis as well as cartilage and bone degradation[4].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Collagen-induced arthritis in male DBA/1 mice[4]
Dosage: 80 or 120 μg/kg
Administration: After the onset of disease s.c. every day for 13 days
Result: Reduced serum IgG2a levels as well as T cell activation, with the downregulation of RORγt+CD4+ T cells and upregulation of FoxP3+CD8+ T cells in lymph nodes.
Decreased the levels of key cytokines, such as interleukin (IL)-1β, IL-2, IL-6, IL-17, and tumor necrosis factor-α in mice paws, whereas enhanced IL-10.
Molecular Weight

619.67

Formula

C27H41N9O8
CAS No.
Sequence

Thr-Arg-Ser-Ala-Trp
Sequence Shortening

TRSAW
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Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Osteostatin Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Osteostatin138949-73-2PTHrP (107–111)PTHRParathyroid hormone receptorPBMCsosteoclastic boneNFATc1bone defectsArthritisInhibitorinhibitorinhibit

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