Antitumor agent-56
Antitumor agent-56 (Compound 33) is a triptolide derivative with antitumor, anti-inflammatory and NO release activities. Antitumor agent-56 significantly inhibits the growth of melanoma. Antitumor agent-56 is orally active.
For research use only. We do not sell to patients.
- CAS No.: 2411579-53-6
- Formula: C28H28N2O10S
- Molecular Weight:584.59
-
Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Biological Activity
-
Chemical Information
- Purity & Documentation
- References
-
Help & FAQs
Biological Activity
|
Cell Line
|
Type | Value | Description | References |
|---|---|---|---|---|
| B16-F10 | IC50 |
0.021 μM
Compound: 33
|
Antiproliferative activity against human B16-F10 cells assessed as reduction in cell growth incubated for 96 hrs by MTT assay
Antiproliferative activity against human B16-F10 cells assessed as reduction in cell growth incubated for 96 hrs by MTT assay
|
[PMID: 32028140] |
| BGC-823 | IC50 |
0.95 μM
Compound: 33
|
Antiproliferative activity against human BGC-823 cells assessed as reduction in cell growth incubated for 96 hrs by MTT assay
Antiproliferative activity against human BGC-823 cells assessed as reduction in cell growth incubated for 96 hrs by MTT assay
|
[PMID: 32028140] |
| HCT-116 | IC50 |
0.034 μM
Compound: 33
|
Antiproliferative activity against human HCT-116 cells assessed as reduction in cell growth incubated for 96 hrs by MTT assay
Antiproliferative activity against human HCT-116 cells assessed as reduction in cell growth incubated for 96 hrs by MTT assay
|
[PMID: 32028140] |
| HepG2 | IC50 |
0.95 μM
Compound: 33
|
Antiproliferative activity against human HepG2 cells assessed as reduction in cell growth incubated for 96 hrs by MTT assay
Antiproliferative activity against human HepG2 cells assessed as reduction in cell growth incubated for 96 hrs by MTT assay
|
[PMID: 32028140] |
| NCI-H1650 | IC50 |
1.57 μM
Compound: 33
|
Antiproliferative activity against human NCI-H1650 cells assessed as reduction in cell growth incubated for 96 hrs by MTT assay
Antiproliferative activity against human NCI-H1650 cells assessed as reduction in cell growth incubated for 96 hrs by MTT assay
|
[PMID: 32028140] |
| RAW264.7 | IC50 |
0.086 μM
Compound: 33
|
Antiinflammatory activity against mouse RAW264.7 cells assessed as inhibition of LPS-induced TNF-alpha incubated for 1 hr followed by LPS stimulation and measured after 24 hrs by ELISA
Antiinflammatory activity against mouse RAW264.7 cells assessed as inhibition of LPS-induced TNF-alpha incubated for 1 hr followed by LPS stimulation and measured after 24 hrs by ELISA
|
[PMID: 32028140] |
| RAW264.7 | IC50 |
0.117 μM
Compound: 33
|
Antiinflammatory activity against mouse RAW264.7 cells assessed as inhibition of LPS-induced IL-6 incubated for 1 hr followed by LPS stimulation and measured after 24 hrs by ELISA
Antiinflammatory activity against mouse RAW264.7 cells assessed as inhibition of LPS-induced IL-6 incubated for 1 hr followed by LPS stimulation and measured after 24 hrs by ELISA
|
[PMID: 32028140] |
Chemical Information
-
CAS No. 2411579-53-6
-
Molecular Weight 584.59
-
Formula C28H28N2O10S
-
SMILES
C[C@@]12[C@@]34[C@@]5([C@@](C[C@@]1([H])C6=C(C(OC6)=O)CC2)([H])O5)[C@@H]([C@@]7([C@](O7)([H])[C@]3([H])O4)C(C)C)OC8=NO[N+]([O-])=C8S(=O)(C9=CC=CC=C9)=O
-
Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Antitumor agent-56 Related Classifications
HY-146046 Related Classifications
Powered by Bioz