2. Membrane Transporter/Ion Channel Neuronal Signaling
  3. TRP Channel
  4. 17(R)-Resolvin D1

17(R)-Resolvin D1  (Synonyms: 17(R)-RvD1; AT-RvD1)

Cat. No.: HY-125527A
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17R-Resolvin D1 (17R-RvD1; AT-RvD1) is an aspirin-triggered epimer of Resolvin D1, which exhibits anti-inflammatory activity in mice and human PMNs cells. 17R-Resolvin D1 specificially inhibits TRPV3 with an IC50 of 398 nM and exhibits peripheral anti-nociceptive efficacy.

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17(R)-Resolvin D1 Chemical Structure

17(R)-Resolvin D1 Chemical Structure

CAS No. : 528583-91-7

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17(R)-Resolvin D1 Related Antibodies

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Description

17R-Resolvin D1 (17R-RvD1; AT-RvD1) is an aspirin-triggered epimer of Resolvin D1, which exhibits anti-inflammatory activity in mice and human PMNs cells[1]. 17R-Resolvin D1 specificially inhibits TRPV3 with an IC50 of 398 nM and exhibits peripheral anti-nociceptive efficacy[2].

IC50 & Target

TRPV3

398 nM (IC50)

In Vitro

17R-Resolvin D1 (0-1000 nM) dose-dependently reduces fMLP-induced human polymorphonuclear leukocyte (PMN) transendothelial migration as first event in acute inflammation response[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

17(R)-Resolvin D1 Related Antibodies

Cell Migration Assay [1]

Cell Line: PMNs
Concentration: 0-1000 nM
Incubation Time: 30 min
Result: Reduced fMLP-induced human PMNs transendothelial migration in a dose-dependent manner, reduced 65% PMNs transmigration at the concentration of 1 μM.
In Vivo

17R-Resolvin D1 (0.05-50 μg/kg, i.v.) reduces PMN infiltration with a maximal inhibition of 35% at a dose of 100 ng/kg in FVB mice[1].
17R-Resolvin D1 (30 µM in 20 µL, i.d.) reduces the TRPV3-specific acute pain in CFA-inflamed ICR mice[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Murine peritonitis bearing FVB mice[1]
Dosage: 0.05-50 μg/kg
Administration: i.v., single dosage
Result: Reduced total leukocytic infiltration, the maximal decrease in total leukocytes with a 100 ng dose.
Animal Model: CFA-inflamed ICR mice[2]
Dosage: 30 µM in 20 µL
Administration: i.d.
Result: Reduced the heat threshold in animals with a CFA-inflamed hind paw.
Molecular Weight

376.49

Formula

C22H32O5
CAS No.
SMILES

CC/C=C\C[C@@H](O)/C=C/C=C\C=C\C=C\[C@@H](O)[C@@H](O)C/C=C\CCC(O)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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17(R)-Resolvin D1 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

17(R)-Resolvin D1528583-91-717(R)-RvD1 AT-RvD1TRP ChannelTransient receptor potential channelshuman polymorphonuclear leukocyteperitonitisFVB miceInhibitorinhibitorinhibit

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