17(R)-Resolvin D1
Based on 1 publication(s) in Google Scholar
17R-Resolvin D1 (17R-RvD1; AT-RvD1) is an aspirin-triggered epimer of Resolvin D1, which exhibits anti-inflammatory activity in mice and human PMNs cells. 17R-Resolvin D1 specificially inhibits TRPV3 with an IC50 of 398 nM and exhibits peripheral anti-nociceptive efficacy.
연구목적의 판매만을 진행합니다. 환자를 대상으로 한 판매는 하지 않습니다.
- Purity: 99.11%
- CAS No.: 528583-91-7
- 화학식: C22H32O5
- 분자량:376.49
-
보관:
-80°C, protect from light
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Biological Activity
-
Chemical Information
- 순도&문서
- References
-
Help & FAQs
-
HY-113509
Lipoxin A4
-
HY-125527
Resolvin D1
-
HY-113533
Resolvin D4
-
HY-125516
MCTR3
-
HY-121636
Resolvin D2
-
HY-125408
Maresin conjugates in tissue regeneration 1
-
HY-130322
Maresin Conjugates in Tissue Regeneration 2
-
HY-145491
Resolvin D5
-
HY-170645
Neuroprotectin D1 methyl ester
-
HY-155286
(7S,8R,17S)-RCTR1
-
HY-125445
PCTR1
-
HY-N7109B
Erucic acid sodium
Publications Citing Use of MedChemExpress (MCE) 17(R)-Resolvin D1
More
Biological Activity
|
TRPV3 398 nM (IC50) |
17R-Resolvin D1 (0-1000 nM) dose-dependently reduces fMLP-induced human polymorphonuclear leukocyte (PMN) transendothelial migration as first event in acute inflammation response[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
-
Cell Line:PMNs
-
Concentration:0-1000 nM
-
Incubation Time:30 min
-
Result:Reduced fMLP-induced human PMNs transendothelial migration in a dose-dependent manner, reduced 65% PMNs transmigration at the concentration of 1 μM.
17R-Resolvin D1 (30 µM in 20 µL, i.d.) reduces the TRPV3-specific acute pain in CFA-inflamed ICR mice[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
-
Animal Model:Murine peritonitis bearing FVB mice[1]
-
Dosage:0.05-50 μg/kg
-
Administration:i.v., single dosage
-
Result:Reduced total leukocytic infiltration, the maximal decrease in total leukocytes with a 100 ng dose.
-
Animal Model:CFA-inflamed ICR mice[2]
-
Dosage:30 µM in 20 µL
-
Administration:i.d.
-
Result:Reduced the heat threshold in animals with a CFA-inflamed hind paw.
Chemical Information
-
CAS No. 528583-91-7
-
Appearance Liquid
-
분자량 376.49
-
화학식 C22H32O5
-
Color Colorless to light yellow
-
SMILES
CC/C=C\C[C@@H](O)/C=C/C=C\C=C\C=C\[C@@H](O)[C@@H](O)C/C=C\CCC(O)=O
-
Synonyms
17(R)-RvD1; AT-RvD1
-
선적
Shipping with dry ice.
-
보관
-80°C, protect from light
Publications (1)
-
Journal Impact Factor
-
Most Recent
-
Drug Des Devel Ther
17(R)-RvD1 Ameliorates Liver Injury in Hyperuricemia Through Inhibiting Pyroptosis via NF-κB Signaling Pathway. [Abstract]2025 Jul 30:19:6573-6585. PMID: 40756265
순도&문서
-
Data Sheet (268 KB)
-
SDS (394 KB)
- English - EN (394 KB)
- Français - FR (394 KB)
- Deutsch - DE (394 KB)
- Norwegian - NO (394 KB)
- Español - ES (394 KB)
- Swedish - SV (394 KB)
- Italian - IT (394 KB)
- Korean - KR (394 KB)
- Portuguese - PT (394 KB)
-
Handling Instructions (2659 KB)
References
[1]. Sun YP, et al., Resolvin D1 and its aspirin-triggered 17R epimer. Stereochemical assignments, anti-inflammatory properties, and enzymatic inactivation. J Biol Chem. 2007 Mar 30;282(13):9323-9334. [Content Brief]
[2]. Bang S, et al., 17(R)-resolvin D1 specifically inhibits transient receptor potential ion channel vanilloid 3 leading to peripheral antinociception. Br J Pharmacol. 2012 Feb;165(3):683-92. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
17(R)-Resolvin D1 Related Classifications
HY-125527A Related Classifications
Powered by Bioz