17(R)-Resolvin D1
Based on 1 publication(s) in Google Scholar
17R-Resolvin D1 (17R-RvD1; AT-RvD1) is an aspirin-triggered epimer of Resolvin D1, which exhibits anti-inflammatory activity in mice and human PMNs cells. 17R-Resolvin D1 specificially inhibits TRPV3 with an IC50 of 398 nM and exhibits peripheral anti-nociceptive efficacy.
For research use only. We do not sell to patients.
- Purity: 99.69%
- CAS No.: 528583-91-7
- Formula: C22H32O5
- Molecular Weight:376.49
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Storage:
-80°C, protect from light
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Publications Citing Use of MedChemExpress (MCE) 17(R)-Resolvin D1
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Biological Activity
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TRPV3 398 nM (IC50) |
17R-Resolvin D1 (0-1000 nM) dose-dependently reduces fMLP-induced human polymorphonuclear leukocyte (PMN) transendothelial migration as first event in acute inflammation response[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:PMNs
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Concentration:0-1000 nM
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Incubation Time:30 min
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Result:Reduced fMLP-induced human PMNs transendothelial migration in a dose-dependent manner, reduced 65% PMNs transmigration at the concentration of 1 μM.
17R-Resolvin D1 (30 µM in 20 µL, i.d.) reduces the TRPV3-specific acute pain in CFA-inflamed ICR mice[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Murine peritonitis bearing FVB mice[1]
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Dosage:0.05-50 μg/kg
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Administration:i.v., single dosage
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Result:Reduced total leukocytic infiltration, the maximal decrease in total leukocytes with a 100 ng dose.
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Animal Model:CFA-inflamed ICR mice[2]
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Dosage:30 µM in 20 µL
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Administration:i.d.
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Result:Reduced the heat threshold in animals with a CFA-inflamed hind paw.
Chemical Information
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CAS No. 528583-91-7
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Appearance Liquid
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Molecular Weight 376.49
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Formula C22H32O5
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Color Colorless to light yellow
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SMILES
CC/C=C\C[C@@H](O)/C=C/C=C\C=C\C=C\[C@@H](O)[C@@H](O)C/C=C\CCC(O)=O
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Synonyms
17(R)-RvD1; AT-RvD1
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Shipping
Shipping with dry ice.
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Storage
-80°C, protect from light
Publications (1)
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Journal Impact Factor
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Most Recent
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Drug Des Devel Ther
17(R)-RvD1 Ameliorates Liver Injury in Hyperuricemia Through Inhibiting Pyroptosis via NF-κB Signaling Pathway. [Abstract]2025 Jul 30:19:6573-6585. PMID: 40756265
Purity & Documentation
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Data Sheet (268 KB)
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SDS (394 KB)
- English - EN (394 KB)
- Français - FR (394 KB)
- Deutsch - DE (394 KB)
- Norwegian - NO (394 KB)
- Español - ES (394 KB)
- Swedish - SV (394 KB)
- Italian - IT (394 KB)
- Korean - KR (394 KB)
- Portuguese - PT (394 KB)
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Handling Instructions (2659 KB)
References
[1]. Sun YP, et al., Resolvin D1 and its aspirin-triggered 17R epimer. Stereochemical assignments, anti-inflammatory properties, and enzymatic inactivation. J Biol Chem. 2007 Mar 30;282(13):9323-9334. [Content Brief]
[2]. Bang S, et al., 17(R)-resolvin D1 specifically inhibits transient receptor potential ion channel vanilloid 3 leading to peripheral antinociception. Br J Pharmacol. 2012 Feb;165(3):683-92. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
17(R)-Resolvin D1 Related Classifications
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