528583-91-7
528583-91-7
Chemical Structure
17(R)-Resolvin D1
Synonym(s): 17(R)-RvD1; AT-RvD1
- CAS No.: 528583-91-7
- Formula:C22H32O5
- Molecular Weight:376.49
IUPAC Name: (4Z,7S,8R,9E,11E,13Z,15E,17R,19Z)-7,8,17-trihydroxydocosa-4,9,11,13,15,19-hexaenoic acid
InChIKey: OIWTWACQMDFHJG-BJEBZIPWSA-N
SMILES: CC/C=C\C[C@@H](O)/C=C/C=C\C=C\C=C\[C@@H](O)[C@@H](O)C/C=C\CCC(O)=O
Biological Activity: 17R-Resolvin D1 (17R-RvD1; AT-RvD1) is an aspirin-triggered epimer of Resolvin D1, which exhibits anti-inflammatory activity in mice and human PMNs cells[1]. 17R-Resolvin D1 specificially inhibits TRPV3 with an IC50 of 398 nM and exhibits peripheral anti-nociceptive efficacy[2].
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17(R)-Resolvin D1 | 99.11% | 17R-Resolvin D1 (17R-RvD1; AT-RvD1) is an aspirin-triggered epimer of Resolvin D1, which exhibits anti-inflammatory activity in mice and human PMNs cells. 17R-Resolvin D1 specificially inhibits TRPV3 with an IC50 of 398 nM and exhibits peripheral anti-nociceptive efficacy. | ||||||||||||||||||||
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17(R)-Resolvin D1-d5 | 17(R)-Resolvin D1-d5 (17(R)-RvD1-d5) is deuterium labeled 17(R)-Resolvin D1. 17R-Resolvin D1 (17R-RvD1; AT-RvD1) is an aspirin-triggered epimer of Resolvin D1, which exhibits anti-inflammatory activity in mice and human PMNs cells. 17R-Resolvin D1 specificially inhibits TRPV3 with an IC50 of 398 nM and exhibits peripheral anti-nociceptive efficacy. | |||||||||||||||||||||
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Resolvin D4 | 96.8% | Resolvin D4 (RvD4), a specialized proresolving mediator, can be produced in bioactive levels during S. aureus infection. |
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17(R)-Resolvin D4 | 17(R)-Resolvin D4 (17(R)-RvD4) is the R-enantiomer of Resolvin D4. Resolvin D4 (RvD4), a specialized proresolving mediator, can be produced in bioactive levels during S. aureus infection. |
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Lipoxin A5 | Lipoxin A5 is an eicosapentaenoic acid derived from pig white blood cells. Lipoxin A5 slowly contracted the guinea pig lung parenchymal strips with a contractile force similar to that of LXA4 and LXB4.2, but LXA5 did not have the vasodilating effect on the aortic smooth muscle shown by LXA4 and LXB4.2. | |||||||||||||||||||||
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Resolvin D2 | 99.9% | Resolvin D2 is a metabolite of docosahexaenoic acid (DHA), with anti-inflammatory, anti-infective activities. Resolvin D2 is a potent regulator of leukocytes and controls microbial sepsis. Resolvin D2 is a remarkably potent inhibitor of TRPV1 (IC50 = 0.1 nM) and TRPA1 (IC50 = 2 nM) in primary sensory neurons. | ||||||||||||||||||||
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Resolvin D1 | 99.6% | Resolvin D1 (RvD1), an endogenous pro-resolving mediator of inflammation, is derived from omega-3 docosahexaenoic acid during the resolution phase of acute inflammation. Resolvin D1 blocks proinflammatory neutrophil migration by regulating actin polymerization, reduces TNF-α–mediated inflammation in macrophages, and enhances phagocytosis of apoptotic cells by macrophages. | ||||||||||||||||||||
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Resolvin D1 methyl ester | Resolvin D1 methyl ester (RvD1 methyl ester) is the methyl ester of Resolvin D1 (HY-125527). Resolvin D1 methyl ester reduces triglyceride levels. | |||||||||||||||||||||
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Protectin D1 | 99.0% | Protectin D1, a neuroprotectin D1 produced by neuronal cells, is a member of a newly discovered family of bioactive products derived from docosahexaenoic acid. Protectin D1 also serves as a specialized pro-resolving mediator, exhibiting effective in vivo pro-resolving activity in various human disease models. Additionally, Protectin D1 is an inhibitor of NALP3 inflammasomes and regulates the PI3K/AKT and HIF-1α signaling pathways. Protectin D1 exerts anti-inflammatory effects by reducing ROS levels, inhibiting the expression of NALP3, ASC, and Caspase-1, and consequently decreasing the release of pro-inflammatory cytokines IL-1β and IL-18. Furthermore, Protectin D1 enhances miRNA-210 expression, activates the PI3K/AKT signaling pathway, and exerts cardioprotective effects. Protectin D1 holds promise for research in cardiovascular diseases and inflammatory disorders. | ||||||||||||||||||||
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17(R)-Resolvin D1 methyl ester | 17(R)-Resolvin D1 methyl ester is the methyl ester of Resolvin D1 (RvD1) (HY-125527) induced by Aspirin (HY-14654) with the 17R epimer (AT-RvD1). RvD is a regulator of transendothelial migration of human polymorphonuclear leukocytes and an anti-inflammatory agent. The 17R-trihydroxy-4Z of RvD1 also blocks transendothelial migration of human neutrophils (EC50 approximately 30 nM). AT-RvD1 is an effective form that protects against the rapid inactivation of Resolvin D1. | |||||||||||||||||||||
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Resolvin D2 n-3 DPA | Resolvin D2 n-3 DPA is a specialized proresolving mediator (SPM). Resolvin D2 n-3 DPA (1 nM) can reduce the chemotaxis and adhesion of human neutrophils induced by TNF-α. Resolvin D2 n-3 DPA (100 ng/mouse; intravenous injection) can reduce neutrophil infiltration in the peritoneum and the levels of IL-6 and the chemokine (C-C motif) ligand 2 (CCL2) in a mouse model of inflammation induced by zinc oxide. | |||||||||||||||||||||
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Resolvin D2 methyl ester | Resolvin D2 methyl ester is an ester derivative of the DHA (HY-B2167) metabolite Resolvin D2 (HY-121636) with anti-inflammatory and anti-infective activities. Resolvin D2 is a leukocyte modulator and a potent inhibitor of neuronal TRPV1 (IC50=0.1 nM) and TRPA1 (IC50=2 nM). Resolvin D2 can be used in sepsis research. | |||||||||||||||||||||
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References
- [1]. Sun YP, et al., Resolvin D1 and its aspirin-triggered 17R epimer. Stereochemical assignments, anti-inflammatory properties, and enzymatic inactivation. J Biol Chem. 2007 Mar 30;282(13):9323-9334. [Content Brief]
- [2]. Bang S, et al., 17(R)-resolvin D1 specifically inhibits transient receptor potential ion channel vanilloid 3 leading to peripheral antinociception. Br J Pharmacol. 2012 Feb;165(3):683-92. [Content Brief]
