1. Metabolic Enzyme/Protease
  2. Endogenous Metabolite
  3. Resolvin D1

Resolvin D1 (Synonyms: RvD1)

Cat. No.: HY-125527
Handling Instructions

Resolvin D1 (RvD1), an endogenous pro-resolving mediator of inflammation, is derived from omega-3 docosahexaenoic acid during the resolution phase of acute inflammation. Resolvin D1 blocks proinflammatory neutrophil migration by regulating actin polymerization, reduces TNF-α–mediated inflammation in macrophages, and enhances phagocytosis of apoptotic cells by macrophages.

For research use only. We do not sell to patients.

Resolvin D1 Chemical Structure

Resolvin D1 Chemical Structure

CAS No. : 872993-05-0

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Description

Resolvin D1 (RvD1), an endogenous pro-resolving mediator of inflammation, is derived from omega-3 docosahexaenoic acid during the resolution phase of acute inflammation. Resolvin D1 blocks proinflammatory neutrophil migration by regulating actin polymerization, reduces TNF-α–mediated inflammation in macrophages, and enhances phagocytosis of apoptotic cells by macrophages[1][2].

IC50 & Target[1]

Human Endogenous Metabolite

 

In Vitro

Resolvin D1 (RvD1) (1-100 nM; 15 minutes) induces dose-dependent short-term functional changes in primary human macrophages. RvD1 triggers intracellular Ca2+ release, blocks chemotactic migration, and stimulates phagocytosis of microbial particles with maximal efficiency at 10 nM[1]. Resolvin D1 (0-500 nM; 72 hours) shows a strong inhibition of LPS-induced TRAP and cathepsin K expression by RvD1 at different concentrations in RAW264.7 macrophages[2].

In Vivo

Resolvin D1 (RvD1) (100-1000 ng; i.p.; daily on days 10) improves RA (rheumatoid arthritis) clinical endpoints in arthritic mice[3].

Animal Model: 18-20 g thirty 8-week-old female DBA/1J mice (collagen antibody-induced arthritis (CAIA))[3]
Dosage: 100, 500, and 1000 ng (or 1000 ng, daily on days 4-10)
Administration: i.p. injection; daily on days 10
Result: Exhibit a reduced arthritic score.
Molecular Weight

376.49

Formula

C₂₂H₃₂O₅

CAS No.

872993-05-0

SMILES

CC/C=C\C[[email protected]@H](/C=C/C=C\C=C\C=C\[[email protected]]([[email protected]](C/C=C\CCC(O)=O)O)O)O

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Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

Resolvin D1RvD1Resolvin D 1Resolvin D-1RvD 1RvD-1Endogenous Metabolitepro-resolvingmediatorinflammationacutepolymerizationTNF-αneutrophilapoptoticrheumatoidarthritismacrophagesInhibitorinhibitorinhibit

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Resolvin D1
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