2. Anti-infection
  3. Bacterial
  4. Resolvin D4

Resolvin D4 (RvD4), a specialized proresolving mediator, can be produced in bioactive levels during S. aureus infection.

For research use only. We do not sell to patients.

Resolvin D4 Chemical Structure

Resolvin D4 Chemical Structure

CAS No. : 1025684-60-9

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Resolvin D4 Related Antibodies

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Description

Resolvin D4 (RvD4), a specialized proresolving mediator, can be produced in bioactive levels during S. aureus infection[1].
In Vitro

Resolvin D4 (RvD4) stops neutrophil infiltration in sterile peritonitis and S. aureus skin infection[1].
Resolvin D4 (RvD4, 0-10 nM) enhances human macrophage and dermal fibroblast phagocytosis and efferocytosis[1].
Resolvin D4 (RvD4, 0-10 nM) statistically significantly increases macrophage efferocytosis of apoptotic neutrophils by 40-50%[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Resolvin D4 Related Antibodies
In Vivo

Resolvin D4 (RvD4, 10 ng/mouse) decreases percent of PMN, giving ~31% reduction at 4 hours[1].
Resolvin D4 (RvD4, 10 ng/mouse) modulates the severity of thrombo-inflammatory disease in vivo and improves thrombus resolution[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: 6-8-week-old male FVB mice (a self-limited bacterial inoculation (105 c.f.u) into the dorsal pouch)[1].
Dosage: 200 ng/mouse (saline containing 0.01% EtOH).
Administration: I.P..
Result: Gave lower PMN levels in the cavity in mice treated with RvD4.
Significantly lowered bacterial counts when compared to vehicle control.
Stopped leukocyte influx to the site of infection in the dorsal pouch cavity as well as the inflammation-initiating eicosanoids by reducing levels of PGD2 and LTB4.
Animal Model: Thrombus-bearing mice[2].
Dosage: 3 µg.
Administration: IV via tail vein injection on day 1 and day 4 after IVC stenosis.
Result: Accelerated venous thrombus resolution in mice.
Molecular Weight

376.49

Formula

C22H32O5
CAS No.
SMILES

CC/C=C\C[C@H](O)/C=C/C=C\C/C=C\C=C\C=C\[C@@H](O)[C@@H](O)CCC(O)=O
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Resolvin D4 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Resolvin D41025684-60-9RvD4Resolvin D 4Resolvin D-4RvD 4RvD-4Bacterialproresolving mediatorneutrophil infiltrationphagocytosisefferocytosisthrombus resolutionInhibitorinhibitorinhibit

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