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PCTR1 is a potent monocyte/macrophage agonist, regulating key anti-inflammatory and pro-resolving processes during bacterial infection. PCTR1 is a member of the protectin family of specialized pro-resolving mediators (SPMs).

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PCTR1 Chemical Structure

PCTR1 Chemical Structure

CAS No. : 1810710-59-8

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Based on 1 publication(s) in Google Scholar

PCTR1 Related Antibodies

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Description

PCTR1 is a potent monocyte/macrophage agonist, regulating key anti-inflammatory and pro-resolving processes during bacterial infection. PCTR1 is a member of the protectin family of specialized pro-resolving mediators (SPMs)[1].

In Vitro

PCTR1 is a peptide-containing lipid mediator. PCTR1 is temporally regulated during self-limited inflammation and promotes the resolution of bacterial infection. PCTR1 significantly decreases prostaglandin (PG)E2 (48%), PGD2 (64%), PGF2α (38%), and thromboxane B2 (40%). PCTR1 increases exudate macrophage levels, accelerates clearance of E. coli infection, decreases local inflammatory mediator production, and promotes resolution[1].
PCTR1 is an agonist of human keratinocyte migration and has unique structural features that impart this agonist activity. PCTR1 enhances human keratinocyte migration in a cAMP/PKA-dependent manner. Stimulation of keratinocytes with PCTR1 (10 nM; 15 minutes) significantly elevates levels of cAMP[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

PCTR1 Related Antibodies

Cell Viability Assay[2]

Cell Line: Primary human epidermal keratinocytes (HPEKp)
Concentration: 0.1, 1, and 10 nM
Incubation Time: 24 hours
Result: In comparison with untreated cells in which approximately 25% of the initially wounded area was covered by cells 24 hours after wounding, 10 nM significantly enhanced migration such that approximately 46% of the wound area was covered by cells at 24 hours after wounding.
In Vivo

PCTR1, a lipid mediator, exerts fundamental anti-inflammation and pro-resolution during infection[3].
PCTR1 (50 ng/mice) improves the survival rate in an LPS-induced acute inflammatory mouse model[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: C57BL/6J wild-type male mice (8-10 weeks old, 22-25 g)[3]
Dosage: 50 ng/mice
Administration: Administered via the tail vein 1 h after LPS (15 mg/kg) intraperitoneal injection. The survival rate was recorded every day for 7 days
Result: Compared with the LPS group, the survival rate was significantly higher in the LPS + PCTR1 group, indicating that PCTR1 markedly increases the survival rate.
Molecular Weight

649.80

Formula

C32H47N3O9S
CAS No.
SMILES

CC/C=C\C[C@@H]([C@@H](/C=C/C=C/C=C\C/C=C\C/C=C\CCC(O)=O)SC[C@H](NC(CC[C@H](N)C(O)=O)=O)C(NCC(O)=O)=O)O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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PCTR1 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

PCTR11810710-59-8PCTR 1PCTR-1OthersMonocytemacrophageanti-inflammatorypro-resolvingprotectinSPMInhibitorinhibitorinhibit

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