MCTR3 

MCTR3 is a potent cytokine of pro-resolving mediating maresin conjugates in tissue regeneration (MCTR), which reduces the inflammatory response and promotes the tissue regeneration. MCTR3 exhibits potency in ameliorating LPS-induced acute lung injury and arthritis^[1][2][3].

MCTR3 (1 nM) alleviates LPS-induced cellular damage and oxidative stress, reduces apoptosis and autophagy-related protein production in cells MLE12 through the ALX/PINK1 pathway^[1].
MCTR3 (1 nM) enhances efferocytosis and bacterial phagocytosis by exudate leukocytes, reduces neutrophil infiltration and eicosanoids^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

MCTR3 (2 ng/g, i.p., single dose) reduces inflammation and oxidative response in the LPS-induced acute lung injury and decreases the apoptosis in C57BL/6 mice^[1].
MCTR3 (1-100 nM, in cold water) stimulates tissue regeneration in surgical injuried Planaria in a dose-dependent manner with a 50% tissue regeneration TRI₅₀ of 2.5 days^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

463.63

C₂₅H₃₇NO₅S

1784701-63-8

Liquid

Colorless to light yellow

O[C@H]([C@@H](/C=C/C=C/C=C\C/C=C\CCC(O)=O)SC[C@@H](C(O)=O)N)C/C=C\C/C=C\CC

Room temperature in continental US; may vary elsewhere.

Solution, -20°C, 2 years

• [1]. Zhuang R, et al., MCTR3 reduces LPS-induced acute lung injury in mice via the ALX/PINK1 signaling pathway. Int Immunopharmacol. 2021 Jan;90:107142.  [Content Brief]

  [2]. Dalli J et al., Identification and Actions of a Novel Third Maresin Conjugate in Tissue Regeneration: MCTR3. PLoS One. 2016 Feb 16;11(2):e0149319.  [Content Brief]

  [3]. Pistorius K, et al., MCTR3 reprograms arthritic monocytes to upregulate Arginase-1 and exert pro-resolving and tissue-protective functions in experimental arthritis. EBioMedicine. 2022 May;79:103974.  [Content Brief]