1784701-63-8
Chemical Structure
MCTR3
- CAS No.: 1784701-63-8
- Formula:C25H37NO5S
- Molecular Weight:463.63
IUPAC Name: (4Z,7Z,9E,11E,13R,14S,16Z,19Z)-13-(((R)-2-amino-2-carboxyethyl)thio)-14-hydroxydocosa-4,7,9,11,16,19-hexaenoic acid
InChIKey: GIIVKOKEBBFSDI-AIYHDIOKSA-N
SMILES: O[C@H]([C@@H](/C=C/C=C/C=C\C/C=C\CCC(O)=O)SC[C@@H](C(O)=O)N)C/C=C\C/C=C\CC
Biological Activity: MCTR3 is a potent cytokine of pro-resolving mediating maresin conjugates in tissue regeneration (MCTR), which reduces the inflammatory response and promotes the tissue regeneration. MCTR3 exhibits potency in ameliorating LPS-induced acute lung injury and arthritis[1][2][3].
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MCTR3 | 96.87% | MCTR3 is a potent cytokine of pro-resolving mediating maresin conjugates in tissue regeneration (MCTR), which reduces the inflammatory response and promotes the tissue regeneration. MCTR3 exhibits potency in ameliorating LPS-induced acute lung injury and arthritis. | ||||||||||||||||||||
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- [1]. Zhuang R, et al., MCTR3 reduces LPS-induced acute lung injury in mice via the ALX/PINK1 signaling pathway. Int Immunopharmacol. 2021 Jan;90:107142. [Content Brief]
- [2]. Dalli J et al., Identification and Actions of a Novel Third Maresin Conjugate in Tissue Regeneration: MCTR3. PLoS One. 2016 Feb 16;11(2):e0149319. [Content Brief]
- [3]. Pistorius K, et al., MCTR3 reprograms arthritic monocytes to upregulate Arginase-1 and exert pro-resolving and tissue-protective functions in experimental arthritis. EBioMedicine. 2022 May;79:103974. [Content Brief]
Keywords
