1. Protein Tyrosine Kinase/RTK
    Immunology/Inflammation
  2. Btk
    BMX Kinase
    Toll-like Receptor (TLR)
  3. Poseltinib

Poseltinib (Synonyms: HM71224; LY3337641)

Cat. No.: HY-109010
Handling Instructions

Poseltinib, an orally active, selective and irreversible Bruton’s tyrosine kinase (BTK) inhibitor (IC50 =1.95 nM), with 0.3, 2.3 and 2.4-fold selectivity for BTK over BMX, TEC and TXK, respectively. Poseltinib can covalently bind to the active site (cysteine 481 residue) of BTK, and reveales potent inhibition of B cell receptor (BCR), Fc receptor (FcR), Toll-like receptor (TLR) mediated signaling.

For research use only. We do not sell to patients.

Poseltinib Chemical Structure

Poseltinib Chemical Structure

CAS No. : 1353552-97-2

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Description

Poseltinib, an orally active, selective and irreversible Bruton’s tyrosine kinase (BTK) inhibitor (IC50 =1.95 nM), with 0.3, 2.3 and 2.4-fold selectivity for BTK over BMX, TEC and TXK, respectively. Poseltinib can covalently bind to the active site (cysteine 481 residue) of BTK, and reveales potent inhibition of B cell receptor (BCR), Fc receptor (FcR), Toll-like receptor (TLR) mediated signaling[1].

IC50 & Target

IC50: 1.95 nM (BTK)[1]

Molecular Weight

470.52

Formula

C₂₆H₂₆N₆O₃

CAS No.

1353552-97-2

SMILES

O=C(C=C)NC1=CC=CC(OC2=C(OC=C3)C3=NC(NC4=CC=C(N5CCN(C)CC5)C=C4)=N2)=C1

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Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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