Poseltinib (Standard)
Poseltinib (Standard) is the analytical standard of Poseltinib (HY-109010). This product is intended for research and analytical applications. Poseltinib (HM71224) is an orally active, selective, irreversible small molecule Bruton tyrosine Kinase (BTK) inhibitor. With an IC50 of 1.95 nM. Poseltinib effectively inhibits the signaling mediated by B cell receptors (BCR), Fc receptors (FcR), and Toll-like receptors (TLR). Poseltinib has anti-inflammatory activity and can be used in the research of rheumatoid arthritis.
Nos produits utilisent uniquement pour la recherche. Nous ne vendons pas aux patients.
- CAS No.: 1353552-97-2
- Formule: C26H26N6O3
- Masse moléculaire:470.52
-
Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Product Information
-
Chemical Information
- Pureté et documentation
-
Help & FAQs
-
HY-109010
PoseltinibBTK Inhibitor -
HY-128757
RemibrutinibBTK Inhibitor -
HY-17600
AcalabrutinibBTK Inhibitor -
HY-101474A
ZanubrutinibBtk Inhibitor -
HY-19834
FenebrutinibBtk Inhibitor -
HY-112166
RilzabrutinibBTK Inhibitor -
HY-129390
OrelabrutinibBTK Inhibitor -
HY-112215
NemtabrutinibBTK Inhibitor -
HY-131328
PirtobrutinibBTK Inhibitor -
HY-112161
BranebrutinibBTK Inhibitor -
HY-101474AR
Zanubrutinib (Standard)Btk Inhibitor -
HY-101856
BMS-986142BTK Inhibitor
Product Information
Information
Application
The compound is the grade of analytical standard, which is the reference standard supplied assay. It is commonly used in qualitative, quantitative and methodological research experiments in HPLC, GC and MS.
Chemical Information
-
CAS No. 1353552-97-2
-
Masse moléculaire 470.52
-
Formule C26H26N6O3
-
SMILES
O=C(C=C)NC1=CC=CC(OC2=C(OC=C3)C3=NC(NC4=CC=C(N5CCN(C)CC5)C=C4)=N2)=C1
-
Synonyms
HM71224 (Standard); LY3337641 (Standard)
-
Livraison
Room temperature in continental US; may vary elsewhere.
-
Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
[1]. Kim YY, et al. HM71224, a selective Bruton's tyrosine kinase inhibitor, attenuates the development of murine lupus. Arthritis Res Ther. 2017 Sep 26;19(1):211. [Content Brief]
[2]. Park JK, et al. HM71224, a novel Bruton's tyrosine kinase inhibitor, suppresses B cell and monocyte activation and ameliorates arthritis in a mouse model: a potential drug for rheumatoid arthritis. Arthritis Res Ther. 2016 Apr 18;18:91. [Content Brief]
[3]. Byun JY, et al. Target modulation and pharmacokinetics/pharmacodynamics translation of the BTK inhibitor poseltinib for model-informed phase II dose selection. Sci Rep. 2021 Sep 21;11(1):18671. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Poseltinib (Standard) Related Classifications
HY-109010R Related Classifications
Powered by Bioz