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LR-90 

Cat. No.: HY-76383 Purity: 99.49%
Handling Instructions

LR-90 is an advanced glycation end product (AGE) inhibitor, inhibits inflammatory responses in human monocytes. LR-90 is also used in the research of diabetic animal model.

For research use only. We do not sell to patients.

LR-90 Chemical Structure

LR-90 Chemical Structure

CAS No. : 245075-84-7

Size Price Stock Quantity
Free Sample (0.5-1 mg)   Apply now  
10 mM * 1 mL in DMSO USD 390 In-stock
Estimated Time of Arrival: December 31
5 mg USD 250 In-stock
Estimated Time of Arrival: December 31
10 mg USD 450 In-stock
Estimated Time of Arrival: December 31
50 mg USD 1250 In-stock
Estimated Time of Arrival: December 31
100 mg USD 1950 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

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Description

LR-90 is an advanced glycation end product (AGE) inhibitor, inhibits inflammatory responses in human monocytes[1]. LR-90 is also used in the research of diabetic animal model[2].

IC50 & Target

AGE[1]

In Vitro

LR-90 (0, 25, 50, 100, and 200 μM) inhibits RAGE, MCP-1, COX-2, IP-10 and NOX2 mRNA expression in THP-1 cells in a dose-dependent manner, after pretreatment 1 h befor S100b stimulatation for 4 hours[1].
LR-90 (0, 25, 50, 100, and 200 μM) dose-dependently and significantly blocks THP-1 cells adherence to endothelial cells after pretreatment 1 h befor S100b stimulatation for 24 hours[1].
LR-90 (0, 25, 50, 100, and 200 μM, for 24 hours) shows no effect on the cell viability of THP-1 cells[1].

Cell Viability Assay[1]

Cell Line: THP-1 cells
Concentration: 0, 25, 50, 100, and 200 μM
Incubation Time: 24 hours
Result: Showed no cytotoxicity to THP-1 cells.

RT-PCR[1]

Cell Line: THP-1 cells
Concentration: 0, 25, 50, 100, and 200 μM
Incubation Time: One hour before S100b addition for 4 hours
Result: Dose-dependently inhibited mRNA expression of RAGE, MCP-1, COX-2, IP-10, and NOX2 stimulated with S100b.
In Vivo

LR-90 (50 mg/L, p.o. for 27 weeks) significantly reduces plasma lipids, modestly affects hyperglycaemia in ZDF rats[2].
LR-90 (50 mg/L) decreases renal AGE, AGER and lipid peroxidation[2].

Animal Model: Male ZDF rats (13 to 40 weeks)[2]
Dosage: 50 mg/L
Administration: P.O. for 27 weeks
Result: Significantly reduced plasma triacylglycerol and cholesterol by ∼55% and ∼30%, respectively. Modestly affected hyperglycaemia and blood pressure. Lowered the body weight.
Molecular Weight

709.57

Formula

C₃₅H₃₄Cl₂N₄O₈

CAS No.

245075-84-7

SMILES

O=C(NC1=CC=C(C=C1)OC(C)(C)C(O)=O)NC(C(Cl)=C2)=CC=C2CC3=CC=C(C(Cl)=C3)NC(NC4=CC=C(C=C4)OC(C)(C)C(O)=O)=O

Shipping

Room temperature in continental US; may vary elsewhere

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : ≥ 100 mg/mL (140.93 mM)

H2O : < 0.1 mg/mL (insoluble)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.4093 mL 7.0465 mL 14.0930 mL
5 mM 0.2819 mL 1.4093 mL 2.8186 mL
10 mM 0.1409 mL 0.7047 mL 1.4093 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (3.52 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (3.52 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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LR-90
Cat. No.:
HY-76383
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