1. MAPK/ERK Pathway
  2. p38 MAPK

AZD7624 

Cat. No.: HY-103672
Handling Instructions

AZD7624 is an inhaled p38 inhibitor, with potent anti-inflammatory activity.

For research use only. We do not sell to patients.

AZD7624 Chemical Structure

AZD7624 Chemical Structure

CAS No. : 1095004-78-6

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Customer Review

  • Biological Activity

  • Technical Information

  • Purity & Documentation

  • References

Description

AZD7624 is an inhaled p38 inhibitor, with potent anti-inflammatory activity.

IC50 & Target

p38[1]

In Vitro

AZD7624 is an inhaled p38 inhibitor, with potent anti-inflammatory activity. AZD7624 inhibits LPS-induced TNFα in human mononuclear cells, in whole blood as well as in alveolar macrophages in vitro, with pIC50u of 8.4, 8.7, and 9.0[1].

Clinical Trial
Solvent & Solubility
In Vitro: 

10 mM in DMSO

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.0343 mL 10.1717 mL 20.3434 mL
5 mM 0.4069 mL 2.0343 mL 4.0687 mL
10 mM 0.2034 mL 1.0172 mL 2.0343 mL
*Please refer to the solubility information to select the appropriate solvent.
References
Molecular Weight

491.56

Formula

C₂₇H₃₀FN₅O₃

CAS No.

1095004-78-6

SMILES

O=C(NC1CC1)C2=CC(N3C(C(NC4(C5=CC=CC=C5OCCNC)CC4)=NC=C3)=O)=C(C)C(F)=C2

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Shipping

Room temperature in continental US; may vary elsewhere

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The dilution calculator equation

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This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

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Product Name:
AZD7624
Cat. No.:
HY-103672
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AZD7624

Cat. No.: HY-103672