1. Apoptosis
  2. Caspase
  3. Z-YVAD-FMK

Z-YVAD-FMK 

Cat. No.: HY-P1009
Handling Instructions

AA-Z-YVAD-FMK is a cell-permeable, irreversible pan-caspase inhibitor with anti-inflammatory and anti-tumor activities.

For research use only. We do not sell to patients.

Custom Peptide Synthesis

Z-YVAD-FMK Chemical Structure

Z-YVAD-FMK Chemical Structure

CAS No. : 210344-97-1

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Description

AA-Z-YVAD-FMK is a cell-permeable, irreversible pan-caspase inhibitor with anti-inflammatory and anti-tumor activities.

IC50 & Target[1]

Caspase

 

In Vitro

Z-YVAD-FMK (100 μM; 24 hours) significantly downregulated the growth inhibition induced by butyrate in Caco-2 cells[1].
Z-YVAD-FMK (20 μM; pre 1 hour; 24 hours) attenuates the apoptotic induction of III-10 on both HepG2 and BEL-7402 cells, the apoptotic rate of -10 on HepG2 cells is reduced by Z-VAD-FMK from 19.88% to 8.34%, while that on BEL-7402 cells is reduced from 17.56% to 11.98%[4].
Z-YVAD-FMK (1-10 μM; 24 hours) shows inhibitory effect in various cells against TNFr- or anti-CD95-induced cell death, exhibits IC50 values of 0.0015 μM (Murine hepatocytes), 0.027 μM (Murine hepatocytes), 4.8 μM (HepG2), 5.8 μM (HepG2), 1.6 μM (Hela) and 1.1 μM (Jurkat), respectively[5].

Cell Viability Assay[1]

Cell Line: Caco-2 cells
Concentration: 0-100 μM
Incubation Time: 24 hours
Result: Inhibited Caco-2 cells growth.

Apoptosis Analysis[1]

Cell Line: BEL-7402 and HepG2 cells
Concentration: 20 μM
Incubation Time: Pre 1 hour; 24 hours
Result: Induced a caspase-dependent apoptosis in cells.
In Vivo

Z-VAD-FMK (intraperitoneal injection; 10mg/kg; pre- 30 minutes) significantly delayed preterm delivery at 18 hours, but after 36 hours treatment, non different exists between Z-VAD-FMK-pretreated and control groups[3].

Animal Model: Day 14.5 pregnant CD1 mice[3]
Dosage: 10 mg/kg
Administration: Intraperitoneal injection; 10mg/kg; pre-30 minutes
Result: Prevented HK-GBS-induced preterm delivery.
Molecular Weight

630.66

Formula

C₃₁H₃₉FN₄O₉

CAS No.

210344-97-1

Sequence

Z-Tyr-Val-Ala-Asp-FMK

Sequence Shortening

Z-YVAD-FMK

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
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Keywords:

Z-YVAD-FMKCaspaseAnti-inflammatoryanti-tumor,Inhibitorinhibitorinhibit

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