Anti-inflammatory agent 17
Anti-inflammatory agent 17 is a potent and orally active anti-inflammatory agent. Anti-inflammatory agent 17 inhibits the release of IL-6 and TNF-α in vitro experiments without cytotoxicity. Anti-inflammatory agent 17 exhibits anti-inflammatory activity in vivo. Anti-inflammatory agent 17 has the potential for the research of Acute lung injury (ALI).
For research use only. We do not sell to patients.
- CAS No.: 2763226-84-0
- Formula: C20H23NO5
- Molecular Weight:357.40
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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TNF-α 2.576 μM (IC50) |
IL-6 8.254 μM (IC50) |
Anti-inflammatory agent 17 (compound 5b) (10 µM; 24 h) displays no toxicity in J774a.1 cells[1].
Anti-inflammatory agent 17 (1.25, 2.5, 5, 10 µM; 2 h) inhibits the production of IL-6 (IC50=8.254 µM) and TNF-α (IC50=2.576 µM) in J774a.1 cells in a dose-dependent manner[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:J774a.1 cells
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Concentration:10 µM
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Incubation Time:24 h
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Result:Displayed no toxicity in J774a.1 cells.
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Cell Line:J774A.1 cells
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Concentration:1.25, 2.5, 5, 10 µM
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Incubation Time:2 h
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Result:Inhibited the production of IL-6 (IC50=8.254 µM) and TNF-α (IC50=2.576 µM) in J774a.1 cells in a dose-dependent manner.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:C57/BL6 mice[1]
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Dosage:20 mg/kg
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Administration:Intragastric administration
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Result:Exhibited protective effect on LPS-induced ALI in mice.
Chemical Information
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CAS No. 2763226-84-0
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Molecular Weight 357.40
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Formula C20H23NO5
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SMILES
CN(CCCOC1=CC=C(C(C(/C=C/C2=CC(O)=C(C=C2)O)=O)=C1)O)C
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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