1. Autophagy
  2. Autophagy
  3. Trimetazidine

Trimetazidine 

Cat. No.: HY-B0968A
Handling Instructions

Trimetazidine is a selective long chain 3-ketoyl coenzyme A thiolase inhibitor with an IC50 of 75 nM, which can inhibit β-oxidation of free fatty acid (FFA). Trimetazidine is an effective antianginal agent and a cytoprotective drug, has anti-oxidant, anti-inflammatory, antinociceptive and gastroprotective properties. Trimetazidine triggers autophagy. Trimetazidine is also a 3-hydroxyacyl-CoA dehydrogenase (HADHA) inhibitor.

For research use only. We do not sell to patients.

Trimetazidine Chemical Structure

Trimetazidine Chemical Structure

CAS No. : 5011-34-7

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Description

Trimetazidine is a selective long chain 3-ketoyl coenzyme A thiolase inhibitor with an IC50 of 75 nM, which can inhibit β-oxidation of free fatty acid (FFA). Trimetazidine is an effective antianginal agent and a cytoprotective drug, has anti-oxidant, anti-inflammatory, antinociceptive and gastroprotective properties. Trimetazidine triggers autophagy. Trimetazidine is also a 3-hydroxyacyl-CoA dehydrogenase (HADHA) inhibitor[1][2][3][4].

IC50 & Target

IC50: 75 nM (long chain 3-ketoyl coenzyme A thiolase)[2]
β-oxidation[2]
Autophagy[3]
3-hydroxyacyl-CoA dehydrogenase (HADHA)[4]

In Vitro

Trimetazidine (1-100 μM; 24 hours; HUVECs) could enhance the viability of the injured HUVECs induced by oxidation in a certain dose-dependent manner[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay[1]

Cell Line: Human umbilical vein endothelial cells (HUVECs)
Concentration: 1 μM,10 μM,100 μM
Incubation Time: 24 hours
Result: Enhanced the viability of the injured HUVECs induced by oxidation.
In Vivo

Trimetazidine (5-20 mg/kg; oral administration; 1 hour; Swiss albino male mice) in 10 and 20mg/kg doses significantly raises the seizure-threshold current in the ICES test in the mice[5].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Swiss albino male mice (24-35 g)[4]
Dosage: 5 mg/kg, 10 mg/kg and 20 mg/kg;
10 mL/kg body weight
Administration: Oral administration ; 1 hour
Result: In 10 and 20mg/kg doses significantly raised the seizure-threshold current in the ICES test.
Clinical Trial
Molecular Weight

266.34

Formula

C₁₄H₂₂N₂O₃

CAS No.

5011-34-7

SMILES

COC1=CC=C(CN2CCNCC2)C(OC)=C1OC

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Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
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Keywords:

TrimetazidineAutophagyInhibitorinhibitorinhibit

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Trimetazidine
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HY-B0968A
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