1. Metabolic Enzyme/Protease
    Immunology/Inflammation
    Anti-infection
  2. Mitochondrial Metabolism
    Interleukin Related
    Bacterial
  3. Ppc-1

Ppc-1 

Cat. No.: HY-117843
Handling Instructions

Ppc-1 is a mitochondrial uncoupler. Ppc-1 enhances mitochondrial oxygen consumption without adverse effects on ATP production. Ppc-1 is a cell-permeate interleukin-2 (IL-2) inhibitor. Ppc-1 inhibits the Gram-negative periodontopathogen Porphyromonas gingivalis. Ppc-1 has anti-obesity, antibacterial and anti-inflammatory activities.

For research use only. We do not sell to patients.

Ppc-1 Chemical Structure

Ppc-1 Chemical Structure

CAS No. : 1245818-17-0

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Description

Ppc-1 is a mitochondrial uncoupler. Ppc-1 enhances mitochondrial oxygen consumption without adverse effects on ATP production. Ppc-1 is a cell-permeate interleukin-2 (IL-2) inhibitor. Ppc-1 inhibits the Gram-negative periodontopathogen Porphyromonas gingivalis. Ppc-1 has anti-obesity, antibacterial and anti-inflammatory activities[1][2][3][4].

IC50 & Target

Mitochondrial[1]
Interleukin-2 (IL-2)[2]
Porphyromonas gingivalis[4]

In Vitro

Ppc-1 treatment (0-10 μM; 24 hours; Jurkat cells) significant inhibits IL-2 production in Jurkat cells with an IC50 of 4 μM[2].
Ppc-1 (compound 6) has antiproliferative activities in K562 human leukemia, Hela cervical carcinoma, and 3T3-L1 mouse embryonic fibroblast cells. Ppc-1 shows about 50% inhibition at 15 μM in all cell lines. Ppc-1 inhibits the growth of K562 cells with an EC50 of 13 μM[3]. Using the U937-3xκB-LUC human monocytic cell line, Ppc-1 dose-dependently inhibits the lipopolysaccharide-induced NF-κB activation[4].

In Vivo

Ppc-1 (0-10 mg /kg; Intraperitoneal injection; once a week; for 8 weeks; female ICR mice) treatment suppresses weight gain with no abnormal effects on liver or kidney tissues, and no evidence of tumor formation[1].
Serum fatty acid levels are significantly elevated in mice treated with Ppc-1, while body fat content remained low. After a single administration, Ppc-1 distributes into various tissues of individual animals at low levels. Ppc-1 stimulates adipocytes in culture to release fatty acids, which might explain the elevated serum fatty acids in Ppc-1-treated mice[1].

Animal Model: Female ICR mice[1]
Dosage: 0 mg /kg , 0.16 mg /kg, 0.8 mg /kg, 4 mg /kg, and 10 mg /kg
Administration: Intraperitoneal injection; once a week; for 8 weeks
Result: Suppresseed weight gain in animals.
Molecular Weight

355.43

Formula

C₂₁H₂₅NO₄

CAS No.

1245818-17-0

SMILES

O=C(C1=NC2=C(OC/C=C(C)/C)C=CC=C2C(OC)=C1)OC/C=C(C)\C

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Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

Ppc-1Ppc1Ppc 1Mitochondrial MetabolismInterleukin RelatedBacterialILMitochondriaoxygenATPanti-obesityuncouplerIL-2antiproliferativeantibacterialanti-inflammatoryNF-κBInhibitorinhibitorinhibit

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Ppc-1
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HY-117843
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