2. GPCR/G Protein
  3. Leukotriene Receptor
  4. CP-195543

CP-195543 is a potent, selective and orally active leukotriene B4 (LTB4) receptor antagonist with IC50s of 6.8, 37.0 nM for human neutrophils and murine spleen membranes, respectively. CP-195543 blocks CD11b up-regulation. CP-195543 inhibits LTB4-mediated neutrophil infiltration.

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CP-195543

CP-195543 Chemical Structure

CAS No. : 204981-48-6

Size Price Stock Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
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Based on 1 publication(s) in Google Scholar

CP-195543 Related Antibodies

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Description

CP-195543 is a potent, selective and orally active leukotriene B4 (LTB4) receptor antagonist with IC50s of 6.8, 37.0 nM for human neutrophils and murine spleen membranes, respectively. CP-195543 blocks CD11b up-regulation. CP-195543 inhibits LTB4-mediated neutrophil infiltration[1].

IC50 & Target[1]

LTB4

 

In Vitro

CP-195543 inhibits human and mouse neu-trophil chemotaxis mediated by LTB4 with IC50 values of 2.4 nM, 7.5 nM, respectively[1].
CP-195543 (0.1 nM-10 µM; 60 min) blocks CD11b up-regulation on human neutrophils (HN) and murine neutrophils with IC50s of 270, 420 nM for human monocytes and eosinophils, respectively[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

CP-195543 Related Antibodies
In Vivo

CP-195543 (0.01, 0.1, 1, 10 mg/kg for guinea pig; 0.01, 0.1, 1, 10, 100 mg/kg for mice; P.o.; 1 h before injection of LTB4) inhibits LTB4-mediated neutrophil infiltration in guinea pigskin in a dose-dependent manner[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Guinea pig (Injection of LTB4 10, 30, 100 ng/site; injected intradermally)[1]
Dosage: 0.01, 0.1, 1, 10 mg/kg
Administration: P.o.; 1 h before injection of LTB4
Result: Inhibited LTB4-mediated neutrophil infiltration in guinea pigskin in a dose-dependent manner.
Animal Model: Mice (Injection of LTB4 100 ng/site; injected intradermally)[1]
Dosage: 0.01, 0.1, 1, 10, 100 mg/kg
Administration: P.o.; 1 h before injection of LTB4
Result: Inhibited LTB4-mediated neutrophil infiltration in guinea pigskin in a dose-dependent manner.
Molecular Weight

428.40

Formula

C24H19F3O4
CAS No.
Appearance

Solid

Color

Light yellow to yellow

SMILES

O=C(O)C1=CC=C(C(F)(F)F)C=C1C2=CC=C3[C@H](O)[C@@H](CC4=CC=CC=C4)COC3=C2
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (233.43 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.3343 mL 11.6713 mL 23.3427 mL
5 mM 0.4669 mL 2.3343 mL 4.6685 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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This equation is commonly abbreviated as: C1V1 = C2V2

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Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.3343 mL 11.6713 mL 23.3427 mL 58.3567 mL
5 mM 0.4669 mL 2.3343 mL 4.6685 mL 11.6713 mL
10 mM 0.2334 mL 1.1671 mL 2.3343 mL 5.8357 mL
15 mM 0.1556 mL 0.7781 mL 1.5562 mL 3.8904 mL
20 mM 0.1167 mL 0.5836 mL 1.1671 mL 2.9178 mL
25 mM 0.0934 mL 0.4669 mL 0.9337 mL 2.3343 mL
30 mM 0.0778 mL 0.3890 mL 0.7781 mL 1.9452 mL
40 mM 0.0584 mL 0.2918 mL 0.5836 mL 1.4589 mL
50 mM 0.0467 mL 0.2334 mL 0.4669 mL 1.1671 mL
60 mM 0.0389 mL 0.1945 mL 0.3890 mL 0.9726 mL
80 mM 0.0292 mL 0.1459 mL 0.2918 mL 0.7295 mL
100 mM 0.0233 mL 0.1167 mL 0.2334 mL 0.5836 mL
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CP-195543 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

CP-195543204981-48-6CP195543CP 195543Leukotriene Receptorhuman neutrophilsCD11bneutrophil infiltrationguinea piginflammatoryInhibitorinhibitorinhibit

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