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  4. Hapten
  5. Geraniol

Geraniol is an olefin terpene with oral activity. Geraniol inhibits cell proliferation and promotes apoptosis. Geraniol has antibacterial, antifungal, antioxidant, anti-inflammatory and antitumor activities. Geraniol can be used to study diabetes.

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Geraniol Chemical Structure

Geraniol Chemical Structure

CAS No. : 106-24-1

Size Price Stock Quantity
Liquid + Solvent
10 mM * 1 mL in DMSO
ready for reconstitution
 USD 61 In-stock
Solution
10 mM * 1 mL in DMSO USD 61 In-stock
Liquid
100 mg USD 55 In-stock
200 mg   Get quote  
500 mg   Get quote  

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Customer Review

Based on 1 publication(s) in Google Scholar

Other Forms of Geraniol:

Geraniol Related Antibodies

Top Publications Citing Use of Products

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

Geraniol is an olefin terpene with oral activity. Geraniol inhibits cell proliferation and promotes apoptosis. Geraniol has antibacterial, antifungal, antioxidant, anti-inflammatory and antitumor activities. Geraniol can be used to study diabetes[1][2][3][4][5].

IC50 & Target

Human Endogenous Metabolite

 

In Vitro

Geraniol (0.25-1 mM, 24, 48, 72 h) blocks the cell cycle and induces apoptosis in PC-3 cells[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Geraniol Related Antibodies

Cell Viability Assay [2]

Cell Line: PC-3
Concentration: 0.068, 0.125, 0.25, 0.5, 1 mM
Incubation Time: 72 h
Result: Decreased cell growth in a concentration-dependment manner.

Cell Cycle Analysis [2]

Cell Line: PC-3
Concentration: 0.25, 0.5, 1 mM
Incubation Time: 24 h
Result: Increased the percentage of G1 and/or sub-G1 phase cells.

Western Blot Analysis [2]

Cell Line: PC-3
Concentration: 0.25, 0.5, 1 mM
Incubation Time: 24 h
Result: Increased the activity of caspase-3.
Reduced the expressions of four cyclin isotypes (cyclin A, B, D, and E), two of CDK family (CDK1 and CDK4), and two anti-apoptotic Bcl-2 family members (Bcl-2 and Bcl-w).
Elevated the expressions of two CDK inhibitory proteins (p21 and p27) and two pro-apoptotic Bcl-2 family members (Bax and BNIP3).
In Vivo

Geraniol (60, 300 mg/kg, subcutaneously injected into tumor cells daily for 38 consecutive days) inhibits tumor growth in PC-3 nude mouse tumor models[2].
Geraniol (200 mg/kg, orally, for 45 consecutive days) improves hyperglycemia by reducing a key enzyme in carbohydrate metabolism induced by streptomycin (HY-13753) in diabetic rats[3].
Geraniol (100 mg/kg/day, orally, for 4 weeks) alleviates oxidative stress, bioaccumulation, serological and histopathological changes during aluminum chloride hepatopancreas poisoning in male Wistar rats[4].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: PC-3 cell xenograft in nude mice[2]
Dosage: 60, 300 mg/kg
Administration: s.c.
Result: Reduced the tumor volume and weight.
Increased the percentage of apoptotic cells and reduced the expression level of Ki-67.
Animal Model: Streptozotocin-induced diabetic rats [3]
Dosage: 200 mg/kg
Administration: p.o.
Result: Decreased the body weight in diabetes rats and decreased blood glucose and increased plasma insulin to near normal.
Reverted the levels of Hb and HbA1C towards near normal and reversed the activities of these enzymes to near normal.
Animal Model: Aluminum chloride-hepatopancreatic toxicity rats[4]
Dosage: 100 mg/kg
Administration: p.o.
Result: Reduced AST, ALT, ALP, LDH, pancreatic enzymes and FBS levels.
Reduced the MDA and Increased the TAC levels.
Molecular Weight

154.25

Formula

C10H18O
CAS No.
Appearance

Liquid

Color

Colorless to light yellow

SMILES

C/C(C)=C\CC/C(C)=C/CO
Structure Classification
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility
In Vitro: 

DMSO : ≥ 100 mg/mL (648.30 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

H2O : 1 mg/mL (6.48 mM; ultrasonic and warming and heat to 80°C)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 6.4830 mL 32.4149 mL 64.8298 mL
5 mM 1.2966 mL 6.4830 mL 12.9660 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

  • Protocol 1

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% Saline

    Solubility: ≥ 2.5 mg/mL (16.21 mM); Clear solution

    This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).

    Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.

    Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
  • Protocol 2

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in Saline)

    Solubility: ≥ 2.5 mg/mL (16.21 mM); Clear solution

    This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).

    Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.

    Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.

For the following dissolution methods, please prepare the working solution directly. It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

  • Protocol 1

    Add each solvent one by one:  PBS

    Solubility: 100 mg/mL (648.30 mM); Clear solution; Need ultrasonic

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
%
DMSO +
% 
+
%
Tween-80 +
%
Saline
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Calculation results:
Working solution concentration: mg/mL
Method for preparing stock solution: mg drug dissolved in μL  DMSO (Stock solution concentration: mg/mL).

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).
Method for preparing in vivo working solution for animal experiments: Take μL DMSO stock solution, add μL . μL , mix evenly, next add μL Tween 80, mix evenly, then add μL Saline.
 If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Purity & Documentation

Purity: ≥98.0%

COA (240 KB) HNMR (235 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O / DMSO 1 mM 6.4830 mL 32.4149 mL 64.8298 mL 162.0746 mL
5 mM 1.2966 mL 6.4830 mL 12.9660 mL 32.4149 mL
DMSO 10 mM 0.6483 mL 3.2415 mL 6.4830 mL 16.2075 mL
15 mM 0.4322 mL 2.1610 mL 4.3220 mL 10.8050 mL
20 mM 0.3241 mL 1.6207 mL 3.2415 mL 8.1037 mL
25 mM 0.2593 mL 1.2966 mL 2.5932 mL 6.4830 mL
30 mM 0.2161 mL 1.0805 mL 2.1610 mL 5.4025 mL
40 mM 0.1621 mL 0.8104 mL 1.6207 mL 4.0519 mL
50 mM 0.1297 mL 0.6483 mL 1.2966 mL 3.2415 mL
60 mM 0.1080 mL 0.5402 mL 1.0805 mL 2.7012 mL
80 mM 0.0810 mL 0.4052 mL 0.8104 mL 2.0259 mL
100 mM 0.0648 mL 0.3241 mL 0.6483 mL 1.6207 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Geraniol Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Geraniol106-24-1FungalEndogenous MetaboliteApoptosisBacterialAntitumorAnti-inflammationPC-3Prostate cancerDiabetes ratsInhibitorinhibitorinhibit

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