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Immunology and Inflammatory Disease Models p62 Environmental Pollutants Fungal Atg8/LC3 PI3K Autophagy ERK Apoptosis Necroptosis Reactive Oxygen Species (ROS) TNF Receptor
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Citronellol

Cat. No.: HY-W010201

Citronellol

(Synonyms: (±)-Citronellol; (±)-β-Citronellol)

2 Cited Publications

Customer Review

Based on 2 publication(s) in Google Scholar

Citronellol ((±)-Citronellol) is an orally active inducer of apoptosis. Citronellol can prevent oxidative stress, mitochondrial dysfunction, and apoptosis in the SH-SY5Y cell Parkinson's disease model induced by 6-OHDA by regulating the ROS-NO, MAPK/ERK, and PI3K/Akt signaling pathways. Citronellol can induce necroptosis in human lung cancer cells through the TNF-α pathway and accumulation of ROS. Citronellol can reduce the levels of LC-3 and p62 to regulate the autophagy pathway, inhibit oxidative stress and neuroinflammation, and thus have neuroprotective effects on Parkinson's rats. Citronellol exhibits anti-fungal activity against Trichophyton rubrum by inhibiting ergosterol synthesis.

For research use only. We do not sell to patients.

Purity: 98.40%
CAS No.: 106-22-9
Formula: C₁₀H₂₀O
Molecular Weight:156.27

Storage:

4°C, protect from light

* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Citronellol Chemical Structure

CAS No.: 106-22-9

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- Cellular Effect
- In Vitro
- In Vivo
Chemical Information
Publications (2)
Solvent & Solubility
- In Vitro
- In Vivo
Purity & Documentation
References
Help & FAQs
Bioz

Biological Activity

Description

IC₅₀ & Target

IC₅₀: 54.02，40.64，52.51，45.84，50.1 μg/mL (A549、NCI-H1299、NCI-H23、BT-20、PC3 cells) (Apoptosis)^[6].

All PI3K Isoforms :

All ERK Isoforms :

All TNF Receptor Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
HEK293	EC₅₀	>100 μM Compound: Citronellol	Agonist activity at rat TRPA1 expressed in HEK293 cells assessed as increase in intracellular Ca2+ concentration by Fluo-4-AM dye based spectrofluorimetry Agonist activity at rat TRPA1 expressed in HEK293 cells assessed as increase in intracellular Ca2+ concentration by Fluo-4-AM dye based spectrofluorimetry	[PMID: 25455494]
HEK293	IC₅₀	>100 μM Compound: Citronellol	Antagonist activity against human TRPV1 expressed in HEK293 cells assessed as inhibition of capsaicin-induced increase in intracellular Ca2+ concentration by Fluo-4-AM dye based spectrofluorimetry Antagonist activity against human TRPV1 expressed in HEK293 cells assessed as inhibition of capsaicin-induced increase in intracellular Ca2+ concentration by Fluo-4-AM dye based spectrofluorimetry	[PMID: 25455494]
HEK293	IC₅₀	>100 μM Compound: Citronellol	Antagonist activity against rat TRPA1 expressed in HEK293 cells assessed as inhibition of AITC-induced increase in intracellular Ca2+ concentration by Fluo-4-AM dye based spectrofluorimetry Antagonist activity against rat TRPA1 expressed in HEK293 cells assessed as inhibition of AITC-induced increase in intracellular Ca2+ concentration by Fluo-4-AM dye based spectrofluorimetry	[PMID: 25455494]
HEK293	IC₅₀	>100 μM Compound: Citronellol	Antagonist activity against rat TRPM8 expressed in HEK293 cells assessed as inhibition of icilin-induced increase in intracellular Ca2+ concentration by Fluo-4-AM dye based spectrofluorimetry Antagonist activity against rat TRPM8 expressed in HEK293 cells assessed as inhibition of icilin-induced increase in intracellular Ca2+ concentration by Fluo-4-AM dye based spectrofluorimetry	[PMID: 25455494]

In Vitro

Citronellol (50, 100 μg/mL, 72 h) can prevent oxidative stress, mitochondrial dysfunction, and apoptosis in the SH-SY5Y cell Parkinson's disease model induced by 6-OHDA by regulating the ROS-NO, MAPK/ERK, and PI3K/Akt signaling pathways^[2].
Citronellol can be used as a skin contact allergen after forming hydrogen peroxide through self oxidation^[3].
Citronellol (0-100 μg/mL, 48 h) can induce necrotic apoptosis in human lung cancer cell line NCI-H1299 through the TNF-α pathway and accumulation of reactive oxygen species^[6].
Citronellol (0-100 μg/mL, 48 h) exhibits cytotoxicity towards A549, NCI-H1299, NCI-H23, BT-20, and PC3 cells, with IC₅₀ values of 54.02, 40.64, 52.51, 45.84, and 50.1 μg/mL, respectively^[6].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay^[2].

Cell Line:

SH-SY5Y human neuroblastoma cells
Concentration:

50, 100 μg/mL
Incubation Time:

72 h
Result:

Improved the cell viability of SH-SY5Y cells treated with 6-OHDA, reaching levels of 96.25% and 97.56% at concentrations of 50 μ g/mL and 100 μg/mL, respectively.

Cell Cytotoxicity Assay^[6].

Cell Line:

NSCLC cells A549, NCI-H23, NCI-H1299, BT-20, PC3 and MCF-10A
Concentration:

0-100 μg/mL
Incubation Time:

48 h
Result:

Showed toxic effects on 5 cancer cell lines, but had no effect on normal cells (MCF-10A).

In Vivo

Citronellol (25, 50, 100 mg/kg; once daily; 2 weeks; p.o.) has a cardioprotective effect on the cardiotoxicity of Doxorubicin (HY-15142A) induced myocardial ischemia in rats^[1].
Citronellol (25 mg/kg; once daily; 4 weeks; p.o.) can reduce the levels of LC-3 and p62 to regulate autophagy pathway, inhibit oxidative stress and neuroinflammation, thereby exerting neuroprotective effects on Parkinson's rats^[4].
Citronellol (50, 100 mg/kg; once daily; 4 days; p.o.) can protect the kidneys in rhabdomyolysis induced acute kidney injury in mice through its anti apoptotic effect^[5].
Citronellol (12.5, 25, 50 mg/kg; once daily; 20 days; i.p.) exhibits anti-tumor activity in non-small cell lung cancer mice^[6].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Rat myocardial ischemia model established by intraperitoneal injection of DOX (2.5 mg/kg) (HY-15142A) 6 times every other day ^[1].
Dosage:

25, 50, 100 mg/kg
Administration:

Oral gavage (p.o.); once daily; 2 weeks
Result:

Reduced the production of cardiac antioxidant enzymes, pro-inflammatory cytokines, and lipid biomarkers, and increased the expression of anti-inflammatory cytokines.

Animal Model:

Chronic Rotenone (HY-B1756) PD rat model^[4].
Dosage:

25 mg/kg
Administration:

Oral gavage (p.o.); once daily; 4 weeks
Result:

Inhibited Rotenone (HY-B1756) induced reactive oxygen species production, lipid peroxidation, and enhanced Nrf2 expression, catalase, glutathione peroxidase, and superoxide dismutase levels in the brain.

Animal Model:

A mouse model of rhabdomyolysis induced by a single intramuscular injection of 50% glycerol at a dose of 10 ml/kg ^[5].
Dosage:

50, 100 mg/kg
Administration:

Oral gavage (p.o.); once daily; 4 days
Result:

Reduced KIM-1 mRNA and myoglobin levels, as well as cleaved caspase-3 and BAX protein levels in renal tissue.

Animal Model:

NSCLC nude mouse model established by subcutaneous injection of NCI-H1299 cells into the posterior abdomen of 7-week-old BALB/c (nu/nu) nude mice^[6].
Dosage:

12.5, 25, 50 mg/kg
Administration:

Intraperitoneal injection (i.p.); once daily; 20 days
Result:

Inhibited the growth of subcutaneous tumors.

Chemical Information

CAS No. 106-22-9
Appearance Liquid (Density: 0.857 g/cm³)
Molecular Weight 156.27
Formula C₁₀H₂₀O
Color Colorless to light yellow
SMILES

CC(CCC=C(C)C)CCO
Synonyms

(±)-Citronellol; (±)-β-Citronellol
Structure Classification
- Terpenoids
- Other Monoterpenes
Initial Source
- Plants
- Geraniaceae
- Marine natural products
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, protect from light

* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Publications (2)

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Journal Impact Factor

PLoS Biol

A high-throughput behavioral screening platform for measuring chemotaxis by C. elegans. [Abstract]

2024 Jun 27;22(6):e3002672. PMID: 38935621
bioRxiv

An efficient behavioral screening platform classifies natural products and other chemical cues according to their chemosensory valence in C. elegans. [Abstract]

2024 Apr 3:2023.06.02.542933. PMID: 37333363

Solvent & Solubility

In Vitro:

DMSO : ≥ 100 mg/mL (639.92 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

H₂O : < 0.1 mg/mL (insoluble)

* "≥" means soluble, but saturation unknown.

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

6.3992 mL

31.9959 mL

63.9918 mL

5 mM

1.2798 mL

6.3992 mL

12.7984 mL

10 mM

0.6399 mL

3.1996 mL

6.3992 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Dilution Calculator

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

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In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

Stock Solution Working Solution

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline

Solubility: ≥ 2.5 mg/mL (16.00 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.

Protocol 2

Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)

Solubility: ≥ 2.5 mg/mL (16.00 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.

Protocol 3

Add each solvent one by one: 10% DMSO 90% Corn Oil

Solubility: ≥ 2.5 mg/mL (16.00 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL Corn oil, and mix evenly.

Working Solution

For the following dissolution methods, please prepare the working solution directly:

It is recommended to prepare fresh solutions and use them promptly within a short period of time.

The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: PBS

Solubility: 33.33 mg/mL (213.28 mM); Clear solution; Need ultrasonic

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage Dosage
mg/kg
Animal Weight (Per Animal) Animal Weight (Per Animal)
g
Dosing Volume (Per Animal) Dosing Volume (Per Animal)
μL
Number of Animals Number of Animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Please enter your animal formula composition:

%
DMSO +

Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
%
+
+
%
Tween-80 + +
%
Saline +

The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).

Working solution concentration: 0.22 mg/mL

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (280 KB)
SDS (796 KB)
- English - EN (796 KB)
- Français - FR (796 KB)
- Deutsch - DE (796 KB)
- Norwegian - NO (796 KB)
- Español - ES (796 KB)
- Swedish - SV (796 KB)
- Italian - IT (796 KB)
- Portuguese - PT (796 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Munir S, et al. The Protective Effect of Citronellol against Doxorubicin-Induced Cardiotoxicity in Rats. Biomedicines. 2023 Oct 18;11(10):2820. [Content Brief]

[2]. Shao J, et al. Citronellol Prevents 6-OHDA-Induced Oxidative Stress, Mitochondrial Dysfunction, and Apoptosis in Parkinson Disease Model of SH-SY5Y Cells via Modulating ROS-NO, MAPK/ERK, and PI3K/Akt Signaling Pathways. Neurotox Res. 2022 Dec;40(6):2221-2237. [Content Brief]

[3]. Sahli F, et al. Autoxidized citronellol: Free radicals as potential sparkles to ignite the fragrance induced skin sensitizing pathway. Food Chem Toxicol. 2022 Aug;166:113201. [Content Brief]

[4]. Jayaraj RL, et al. Effect of citronellol on oxidative stress, neuroinflammation and autophagy pathways in an in vivo model of Parkinson's disease. Heliyon. 2022 Nov 3;8(11):e11434. [Content Brief]

[5]. Mahmood YS, et al. Protective effect of citronellol in rhabdomyolysis-induced acute kidney injury in mice. J Med Life. 2023 Jul;16(7):1057-1061. [Content Brief]

[6]. Yu WN, et al. Citronellol Induces Necroptosis of Human Lung Cancer Cells via TNF-α Pathway and Reactive Oxygen Species Accumulation. In Vivo. 2019 Jul-Aug;33(4):1193-1201. [Content Brief]

[7]. Pereira Fde O, et al. Antifungal activity of geraniol and citronellol, two monoterpenes alcohols, against Trichophyton rubrum involves inhibition of ergosterol biosynthesis. Pharm Biol. 2015 Feb;53(2):228-34. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
DMSO	1 mM	6.3992 mL	31.9959 mL	63.9918 mL	159.9795 mL
	5 mM	1.2798 mL	6.3992 mL	12.7984 mL	31.9959 mL
	10 mM	0.6399 mL	3.1996 mL	6.3992 mL	15.9980 mL
	15 mM	0.4266 mL	2.1331 mL	4.2661 mL	10.6653 mL
	20 mM	0.3200 mL	1.5998 mL	3.1996 mL	7.9990 mL
	25 mM	0.2560 mL	1.2798 mL	2.5597 mL	6.3992 mL
	30 mM	0.2133 mL	1.0665 mL	2.1331 mL	5.3327 mL
	40 mM	0.1600 mL	0.7999 mL	1.5998 mL	3.9995 mL
	50 mM	0.1280 mL	0.6399 mL	1.2798 mL	3.1996 mL
	60 mM	0.1067 mL	0.5333 mL	1.0665 mL	2.6663 mL
	80 mM	0.0800 mL	0.3999 mL	0.7999 mL	1.9997 mL
	100 mM	0.0640 mL	0.3200 mL	0.6399 mL	1.5998 mL

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Citronellol

Anti-Infection Compound Library

Apoptosis Compound Library

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Publications Citing Use of MedChemExpress (MCE) Citronellol

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Biological Activity

Chemical Information

Publications (2)

Solvent & Solubility