Citronellol-d₃  (Synonyms: (±)-Citronelloll-d₃; (±)-β-Citronelloll-d₃)

Citronellol-d₃ ( (±)-Citronelloll-d₃) is the deuterium labeled Citronellol (HY-W010201). Citronellol ((±)-Citronellol) is an orally active inducer of apoptosis. Citronellol can prevent oxidative stress, mitochondrial dysfunction, and apoptosis in the SH-SY5Y cell Parkinson's disease model induced by 6-OHDA by regulating the ROS-NO, MAPK/ERK, and PI3K/Akt signaling pathways. Citronellol can induce necroptosis in human lung cancer cells through the TNF-α pathway and accumulation of ROS. Citronellol can reduce the levels of LC-3 and p62 to regulate the autophagy pathway, inhibit oxidative stress and neuroinflammation, and thus have neuroprotective effects on Parkinson's rats. Citronellol exhibits anti-fungal activity against Trichophyton rubrum by inhibiting ergosterol synthesis^[2][4][6][7].

1. This compound can be used as a tracer.
2. This compound can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs.

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

159.28

C₁₀H₁₇D₃O

106-22-9

CC(C([2H])([2H])C([2H])O)CC/C=C(C)/C

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Pereira Fde O, et al. Antifungal activity of geraniol and citronellol, two monoterpenes alcohols, against Trichophyton rubrum involves inhibition of ergosterol biosynthesis. Pharm Biol. 2015 Feb;53(2):228-34.  [Content Brief]

  [2]. Munir S, et al. The Protective Effect of Citronellol against Doxorubicin-Induced Cardiotoxicity in Rats. Biomedicines. 2023 Oct 18;11(10):2820.  [Content Brief]

  [3]. Shao J, et al. Citronellol Prevents 6-OHDA-Induced Oxidative Stress, Mitochondrial Dysfunction, and Apoptosis in Parkinson Disease Model of SH-SY5Y Cells via Modulating ROS-NO, MAPK/ERK, and PI3K/Akt Signaling Pathways. Neurotox Res. 2022 Dec;40(6):2221-2237.  [Content Brief]

  [4]. Sahli F, et al. Autoxidized citronellol: Free radicals as potential sparkles to ignite the fragrance induced skin sensitizing pathway. Food Chem Toxicol. 2022 Aug;166:113201.  [Content Brief]

  [5]. Jayaraj RL, et al. Effect of citronellol on oxidative stress, neuroinflammation and autophagy pathways in an in vivo model of Parkinson's disease. Heliyon. 2022 Nov 3;8(11):e11434.  [Content Brief]

  [6]. Mahmood YS, et al. Protective effect of citronellol in rhabdomyolysis-induced acute kidney injury in mice. J Med Life. 2023 Jul;16(7):1057-1061.  [Content Brief]

  [7]. Yu WN, et al. Citronellol Induces Necroptosis of Human Lung Cancer Cells via TNF-α Pathway and Reactive Oxygen Species Accumulation. In Vivo. 2019 Jul-Aug;33(4):1193-1201.  [Content Brief]