1. Immunology/Inflammation
    NF-κB
    Metabolic Enzyme/Protease
    Anti-infection
    Apoptosis
  2. Reactive Oxygen Species
    Fungal
    Mitochondrial Metabolism
    Apoptosis
    Endogenous Metabolite
  3. Nerol

Nerol 

Cat. No.: HY-N7063 Purity: >97.0%
Handling Instructions

Nerol is a constituent of neroli oil. Nerol Nerol triggers mitochondrial dysfunction and induces apoptosis via elevation of Ca2+ and ROS. Antifungal activity.

For research use only. We do not sell to patients.

Nerol Chemical Structure

Nerol Chemical Structure

CAS No. : 106-25-2

Size Price Stock Quantity
10 mM * 1  mL in DMSO USD 55 In-stock
Estimated Time of Arrival: December 31
10 mg USD 50 In-stock
Estimated Time of Arrival: December 31
50 mg USD 150 In-stock
Estimated Time of Arrival: December 31
100 mg USD 250 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

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Customer Review

Based on 1 publication(s) in Google Scholar

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Description

Nerol is a constituent of neroli oil. Nerol Nerol triggers mitochondrial dysfunction and induces apoptosis via elevation of Ca2+ and ROS. Antifungal activity[1][2].

IC50 & Target

Human Endogenous Metabolite

 

In Vitro

Nerol induces apoptosis associated with the generation of ROS and Ca2+ overload in saprotrophic fungus Aspergillus flavus[1].
The antifungal activity of Nerol (NEL) against Candida albicans, a pathogenic fungus, has a minimum inhibitory concentration (MIC) of 4.4μM that causes noteworthy candidacidal activity through an apoptosis-like mechanism[2].
Nerol triggers mitochondrial dysfunction and disruption via elevation of Ca2+ and ROS in Candida albicans[2].

Molecular Weight

154.25

Formula

C₁₀H₁₈O

CAS No.

106-25-2

SMILES

C/C(C)=C/CC/C(C)=C\CO

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Pure form -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : ≥ 100 mg/mL (648.30 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 6.4830 mL 32.4149 mL 64.8298 mL
5 mM 1.2966 mL 6.4830 mL 12.9660 mL
10 mM 0.6483 mL 3.2415 mL 6.4830 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (16.21 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.5 mg/mL (16.21 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (16.21 mM); Clear solution

*All of the co-solvents are provided by MCE.
References

Purity: >97.0%

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Keywords:

NerolReactive Oxygen SpeciesFungalMitochondrial MetabolismApoptosisEndogenous MetaboliteAntifungalCalciumROSNELmitochondrialdysfunctionInhibitorinhibitorinhibit

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Nerol
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