Buddlejasaponin IV
Buddlejasaponin IV (BS‐IV) exerts anti-inflammatory and cytotoxic effects against cancer cells.
For research use only. We do not sell to patients.
- CAS No.: 139523-30-1
- Formula: C48H78O18
- Molecular Weight:943.12
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| A-375 | IC50 |
14.6 μM
Compound: 2
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Cytotoxicity against human A375 cells after 48 hrs by SRB assay
Cytotoxicity against human A375 cells after 48 hrs by SRB assay
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[PMID: 19467877] |
| A549 | IC50 |
38.3 μM
Compound: 2
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Cytotoxicity against human A549 cells after 48 hrs by SRB assay
Cytotoxicity against human A549 cells after 48 hrs by SRB assay
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[PMID: 19467877] |
| ACHN | IC50 |
7.9 μM
Compound: 2
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Cytotoxicity against human ACHN cells after 48 hrs by SRB assay
Cytotoxicity against human ACHN cells after 48 hrs by SRB assay
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[PMID: 19467877] |
| C32 | IC50 |
26.9 μM
Compound: 2
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Cytotoxicity against human C32 cells after 48 hrs by SRB assay
Cytotoxicity against human C32 cells after 48 hrs by SRB assay
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[PMID: 19467877] |
| Caco-2 | IC50 |
40.7 μM
Compound: 2
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Cytotoxicity against human Caco-2 cells after 48 hrs by SRB assay
Cytotoxicity against human Caco-2 cells after 48 hrs by SRB assay
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[PMID: 19467877] |
| COR-L23 | IC50 |
0.4 μM
Compound: 2
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Cytotoxicity against human COR-L23 cells after 48 hrs by SRB assay
Cytotoxicity against human COR-L23 cells after 48 hrs by SRB assay
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[PMID: 19467877] |
| LNCaP | IC50 |
>50 μM
Compound: 2
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Cytotoxicity against human LNCAP cells after 48 hrs by SRB assay
Cytotoxicity against human LNCAP cells after 48 hrs by SRB assay
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[PMID: 19467877] |
| MCF7 | IC50 |
>50 μM
Compound: 2
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Cytotoxicity against human MCF7 cells after 48 hrs by SRB assay
Cytotoxicity against human MCF7 cells after 48 hrs by SRB assay
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[PMID: 19467877] |
| RAW264.7 | IC50 |
10.6 μM
Compound: 2
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Cytotoxicity against mouse RAW264.7 cells by MTT assay
Cytotoxicity against mouse RAW264.7 cells by MTT assay
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[PMID: 19467877] |
| RAW264.7 | IC50 |
4.2 μM
Compound: 2
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Antiinflammatory activity in LPS-stimulated mouse RAW264.7 cells assessed as inhibition of NO production after 24 hrs by Griess reagent method
Antiinflammatory activity in LPS-stimulated mouse RAW264.7 cells assessed as inhibition of NO production after 24 hrs by Griess reagent method
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[PMID: 19467877] |
Buddlejasaponin IV induces cell cycle arrest at G2/M phase and apoptosis in immortalized human oral keratinocytes[1].
Buddlejasaponin IV (BS-IV) exhibits anti-inflammatory effect of through the inhibition of iNOS and COX-2 expression in RAW 264.7 macrophages via the NF-κB inactivation[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 139523-30-1
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Molecular Weight 943.12
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Formula C48H78O18
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SMILES
C[C@]12[C@]3(C=C[C@@]4([H])[C@]2(CC[C@]5([H])[C@@]4(CC[C@H](O[C@@]6([H])[C@@H]([C@H]([C@@H](O)[C@@H](C)O6)O[C@]7([H])O[C@@H]([C@@H](O)[C@H](O)[C@H]7O)CO)O[C@]8([H])O[C@@H]([C@@H](O)[C@H](O)[C@H]8O)CO)[C@@]5(C)CO)C)C)[C@@]9([H])[C@](CO3)(CCC(C)(C)C9)[C@@H](O)C1
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Structure Classification
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Initial Source
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
[1]. Young Sun Hwang, et al. Buddlejasaponin IV induces cell cycle arrest at G2/M phase and apoptosis in immortalized human oral keratinocytes. Phytother Res. 2011 Oct;25(10):1503-10. [Content Brief]
[2]. Jong-Heon Won, et al. Anti-inflammatory effect of buddlejasaponin IV through the inhibition of iNOS and COX-2 expression in RAW 264.7 macrophages via the NF-kappaB inactivation. Br J Pharmacol. 2006 May;148(2):216-25. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Buddlejasaponin IV Related Classifications
HY-125131 Related Classifications
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