1. Terpenoids and Glycosides
  2. Betulonic acid

Betulonic acid (Synonyms: Betunolic acid; Liquidambaric acid; (+)-Betulonic acid)

Cat. No.: HY-N1451 Purity: >98.0%
Handling Instructions

Betulonic acid belongs to the pentacyclic triterpenic derivative class, has antitumor activities.

For research use only. We do not sell to patients.

Betulonic acid Chemical Structure

Betulonic acid Chemical Structure

CAS No. : 4481-62-3

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 66 In-stock
Estimated Time of Arrival: December 31
5 mg USD 60 In-stock
Estimated Time of Arrival: December 31
10 mg USD 84 In-stock
Estimated Time of Arrival: December 31
50 mg   Get quote  
100 mg   Get quote  

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Based on 1 publication(s) in Google Scholar

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Description

Betulonic acid belongs to the pentacyclic triterpenic derivative class, has antitumor activities. In vitro: BEA-NP is found over three-times more permeable than that solubilized by DMSO in Caco-2 cell monocultures.[1] In vivo: The tumor growth in the S180 berry mice orally doses with BEA-NP at 75 mg/kg is inhibited by 50%. Rubusoside is effective in solubilizing BEA, maintaining its cytotoxicity, enhancing its permeability and reducing tumor growth when orally administered.[1] antitumor activities against MGC-803, PC3, Bcap-37, A375, and MCF-7 human cancer cell lines In vivo: The animals are treated with betulonic acid amide (50 mg/kg in Tween aqueous solution) and heptral (6 mg/kg) as hepatoprotective compounds. It is found that betulonic acid amide stimulats the regenerative response in hepatocytes under conditions of combined toxic exposure and promots recovery of their qualitative and quantitative characteristics. [2]

Molecular Weight

454.68

Formula

C₃₀H₄₆O₃

CAS No.

4481-62-3

SMILES
Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 6.67 mg/mL (14.67 mM; Need ultrasonic)

H2O : < 0.1 mg/mL (insoluble)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.1993 mL 10.9967 mL 21.9935 mL
5 mM 0.4399 mL 2.1993 mL 4.3987 mL
10 mM 0.2199 mL 1.0997 mL 2.1993 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 0.67 mg/mL (1.47 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 0.67 mg/mL (1.47 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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Keywords:

Betulonic acidBetunolic acidLiquidambaric acid(+)-Betulonic acidOthersInhibitorinhibitorinhibit

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Betulonic acid
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HY-N1451
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