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Sauchinone 

Cat. No.: HY-N0613
Handling Instructions

Sauchinone is a diastereomeric lignan isolated from Saururus chinensis (Saururaceae). Sauchinone inhibits LPS-inducible iNOS, TNF-α and COX-2 expression through suppression of I-κBα phosphorylation and p65 nuclear translocation. Sauchinone has anti-inflammatory and antioxidant activity.

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Sauchinone Chemical Structure

Sauchinone Chemical Structure

CAS No. : 177931-17-8

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Description

Sauchinone is a diastereomeric lignan isolated from Saururus chinensis (Saururaceae). Sauchinone inhibits LPS-inducible iNOS, TNF-α and COX-2 expression through suppression of I-κBα phosphorylation and p65 nuclear translocation. Sauchinone has anti-inflammatory and antioxidant activity[1].

IC50 & Target

I-kappaBalpha

 

p65

 

In Vitro

Sauchinone (1, 3, 10, 30μm; 6 hours) inhibits LPS-inducible increase in the iNOS mRNA in Raw264.7 cells[1].
Sauchinone at the concentrations of 3 and 30 μm inhibits TNF-α production in LPS-treated cells by 40 and 50%, respectively[1].

Molecular Weight

356.37

Formula

C₂₀H₂₀O₆

CAS No.

177931-17-8

SMILES

C[[email protected]@H]([[email protected]@H](C[[email protected]]12[H])C)[[email protected]](C(C=C(OCO3)C3=C4)=C4O5)([H])[[email protected]@]1([H])[[email protected]]5(OCO6)C6=CC2=O

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Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

SauchinoneNF-κBNuclear factor-κBNuclear factor-kappaBDiastereomericlignanLPSiNOSTNF-αCOX-2anti-inflammatoryantioxidantInhibitorinhibitorinhibit

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