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Sauchinone 

Cat. No.: HY-N0613 Purity: 99.62%
Handling Instructions

Sauchinone is a diastereomeric lignan isolated from Saururus chinensis (Saururaceae). Sauchinone inhibits LPS-inducible iNOS, TNF-α and COX-2 expression through suppression of I-κBα phosphorylation and p65 nuclear translocation. Sauchinone has anti-inflammatory and antioxidant activity.

For research use only. We do not sell to patients.

Sauchinone Chemical Structure

Sauchinone Chemical Structure

CAS No. : 177931-17-8

Size Price Stock Quantity
5 mg USD 80 In-stock
Estimated Time of Arrival: December 31
10 mg USD 140 In-stock
Estimated Time of Arrival: December 31
20 mg USD 230 In-stock
Estimated Time of Arrival: December 31
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Based on 1 publication(s) in Google Scholar

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Description

Sauchinone is a diastereomeric lignan isolated from Saururus chinensis (Saururaceae). Sauchinone inhibits LPS-inducible iNOS, TNF-α and COX-2 expression through suppression of I-κBα phosphorylation and p65 nuclear translocation. Sauchinone has anti-inflammatory and antioxidant activity[1].

IC50 & Target[1]

I-kappaBalpha

 

p65

 

In Vitro

Sauchinone (1, 3, 10, 30μm; 6 hours) inhibits LPS-inducible increase in the iNOS mRNA in Raw264.7 cells[1].
Sauchinone at the concentrations of 3 and 30 μm inhibits TNF-α production in LPS-treated cells by 40 and 50%, respectively[1].

Molecular Weight

356.37

Formula

C₂₀H₂₀O₆

CAS No.

177931-17-8

SMILES

C[[email protected]@H]([[email protected]@H](C[[email protected]]12[H])C)[[email protected]](C(C=C(OCO3)C3=C4)=C4O5)([H])[[email protected]@]1([H])[[email protected]]5(OCO6)C6=CC2=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility
In Vitro: 

DMSO : 22.73 mg/mL (63.78 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.8061 mL 14.0304 mL 28.0607 mL
5 mM 0.5612 mL 2.8061 mL 5.6121 mL
10 mM 0.2806 mL 1.4030 mL 2.8061 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.27 mg/mL (6.37 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.27 mg/mL (6.37 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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Keywords:

SauchinoneNF-κBNuclear factor-κBNuclear factor-kappaBDiastereomericlignanLPSiNOSTNF-αCOX-2anti-inflammatoryantioxidantInhibitorinhibitorinhibit

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Sauchinone
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HY-N0613
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