1. Neuronal Signaling
  2. Amyloid-β
  3. RAGE antagonist peptide TFA

RAGE antagonist peptide TFA 

Cat. No.: HY-P2268A Purity: 99.04%
Handling Instructions

RAGE antagonist peptide TFA is an advanced glycation end products (RAGE) antagonist. RAGE antagonist peptide TFA prevents RAGE from binding with several of its most important ligands, including HMGB-1, S100P, and S100A4. RAGE antagonist peptide TFA possesses anti-tumor and anti-inflammatory activities.

For research use only. We do not sell to patients.

Custom Peptide Synthesis

RAGE antagonist peptide TFA Chemical Structure

RAGE antagonist peptide TFA Chemical Structure

Size Price Stock Quantity
1 mg USD 89 In-stock
Estimated Time of Arrival: December 31
5 mg USD 270 In-stock
Estimated Time of Arrival: December 31
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50 mg   Get quote  

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Based on 1 publication(s) in Google Scholar

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Description

RAGE antagonist peptide TFA is an advanced glycation end products (RAGE) antagonist. RAGE antagonist peptide TFA prevents RAGE from binding with several of its most important ligands, including HMGB-1, S100P, and S100A4. RAGE antagonist peptide TFA possesses anti-tumor and anti-inflammatory activities[1][2].

In Vitro

RAGE antagonist peptide TFA (RAP) reduces the ability of the ligands to stimulate RAGE activation of NFκB in cancer cells in vitro[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

RAGE antagonist peptide TFA (RAP, 100 µg) inhibits RAGE-mediated Basal NFκB Activity in PDAC cells in vivo[1].
RAGE antagonist peptide TFA (RAP) reduces the growth and metastasis of pancreatic tumors and also inhibited glioma tumor growth[1].
In mice bearing asthma, RAGE antagonist peptide TFA (RAP; 4 mg/kg; i.p.) blunts airway reactivity, airway inflammation and goblet cell metaplasia, and decreases release of Th2 cytokines. RAGE antagonist peptide TFA also reduces total, cytoplasmic and nuclear levels of β-catenin, enhances β-catenin phosphorylation at Ser33/37/Thr41, which triggers ubiquitination, down-regulated expression of β-catenin targeted genes, and tends to keep β-catenin at the cytomembrane, shifting β-catenin from a signalling active pattern to an adhesive function[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Cancer cells expressing the NFκB-luc reporter implanted into immune-deficient mice[1].
Dosage: 100 µg
Administration: Intratumoral delivery (or intraperitoneally).
Result: Systemic administration caused a substantial reduction (p<0.05) in the NFκB signal 5 h after injection.
Molecular Weight

1386.58

Formula

C₅₉H₁₀₂F₃N₁₃O₁₉S

Sequence Shortening

Ac-ELKVLMEKEL-NH2

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Sealed storage, away from moisture

Powder -80°C 2 years
-20°C 1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

H2O : 25 mg/mL (18.03 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 0.7212 mL 3.6060 mL 7.2120 mL
5 mM 0.1442 mL 0.7212 mL 1.4424 mL
10 mM 0.0721 mL 0.3606 mL 0.7212 mL
*Please refer to the solubility information to select the appropriate solvent.
References
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Product Name:
RAGE antagonist peptide TFA
Cat. No.:
HY-P2268A
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