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Dorsomorphin dihydrochloride

(Synonyms: Compound C dihydrochloride; BML-275 dihydrochloride)
763 Cited Publications
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Based on 763 publication(s) in Google Scholar

Dorsomorphin (Compound C) dihydrochloride is a potent, selective and ATP-competitive AMPK inhibitor, with a Ki of 109 nM. Dorsomorphin dihydrochloride inhibits BMP pathway by targeting the type I receptors ALK2, ALK3, and ALK6. Dorsomorphin dihydrochloride can reverse autophagy activation and anti-inflammatory effect of Urolithin A (HY-100599).

For research use only. We do not sell to patients.

  • Purity: 99.7%
  • CAS No.: 1219168-18-9
  • Formula: C24H27Cl2N5O
  • Molecular Weight:472.41
  • Storage:

    4°C, sealed storage, away from moisture

    * In solvent : -80°C, 1 year; -20°C, 6 months (sealed storage, away from moisture)

  • Dorsomorphin dihydrochloride Chemical Structure
    Dorsomorphin dihydrochloride Chemical Structure
  • Experimental Validation Results for Dorsomorphin dihydrochloride
  • Experimental Validation Results for Dorsomorphin dihydrochloride
  • Experimental Validation Results for Dorsomorphin dihydrochloride
  • Experimental Validation Results for Dorsomorphin dihydrochloride
  • Experimental Validation Results for Dorsomorphin dihydrochloride
  • Experimental Validation Results for Dorsomorphin dihydrochloride
  • Experimental Validation Results for Dorsomorphin dihydrochloride
  • Experimental Validation Results for Dorsomorphin dihydrochloride
  • Experimental Validation Results for Dorsomorphin dihydrochloride
  • Experimental Validation Results for Dorsomorphin dihydrochloride
  • Experimental Validation Results for Dorsomorphin dihydrochloride
  • Experimental Validation Results for Dorsomorphin dihydrochloride
  • Experimental Validation Results for Dorsomorphin dihydrochloride
  • Experimental Validation Results for Dorsomorphin dihydrochloride
  • Experimental Validation Results for Dorsomorphin dihydrochloride
  • Experimental Validation Results for Dorsomorphin dihydrochloride
  • Experimental Validation Results for Dorsomorphin dihydrochloride
  • Experimental Validation Results for Dorsomorphin dihydrochloride
  • Experimental Validation Results for Dorsomorphin dihydrochloride
  • Experimental Validation Results for Dorsomorphin dihydrochloride
  • Experimental Validation Results for Dorsomorphin dihydrochloride
  • Experimental Validation Results for Dorsomorphin dihydrochloride
  • Experimental Validation Results for Dorsomorphin dihydrochloride
  • Experimental Validation Results for Dorsomorphin dihydrochloride
  • Experimental Validation Results for Dorsomorphin dihydrochloride
  • Experimental Validation Results for Dorsomorphin dihydrochloride
  • Experimental Validation Results for Dorsomorphin dihydrochloride
  • Experimental Validation Results for Dorsomorphin dihydrochloride
  • Experimental Validation Results for Dorsomorphin dihydrochloride
  • Experimental Validation Results for Dorsomorphin dihydrochloride
  • Experimental Validation Results for Dorsomorphin dihydrochloride
  • Experimental Validation Results for Dorsomorphin dihydrochloride
  • Experimental Validation Results for Dorsomorphin dihydrochloride
  • Experimental Validation Results for Dorsomorphin dihydrochloride
  • Experimental Validation Results for Dorsomorphin dihydrochloride
  • Experimental Validation Results for Dorsomorphin dihydrochloride
  • Experimental Validation Results for Dorsomorphin dihydrochloride
CAS No.: 1219168-18-9
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  • Dorsomorphin dihydrochloride Chemical Structure
    Dorsomorphin dihydrochloride Chemical Structure
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  • 1/16

    Dorsomorphin dihydrochloride purchased from MedChemExpress. Usage Cited in: ACS Nano. 2024 Jul 2;18(26):16790-16807. [Abstract]

    Customer Validation
     Dorsomorphin (Compound C) (5 μM; 6 h) inhibits NP (24 h)-induced p-AMPK, p-ULK1, ATG5, and LC3-II upregulation and SQSTM1 and GPX4 downregulation in TC-1 cells.

  • 1/16

    Dorsomorphin dihydrochloride purchased from MedChemExpress. Usage Cited in: ACS Nano. 2024 Jul 2;18(26):16790-16807. [Abstract]

    Customer Validation
     Dorsomorphin (Compound C) (5 μM; 6 h) can alleviate NPs-induced cell death in TC-1 cells.

  • 1/16

    Dorsomorphin dihydrochloride purchased from MedChemExpress. Usage Cited in: Cell Metab. 2021 Mar 2;33(3):565-580.e7. [Abstract]

    Customer Validation
     Immunoblots (proteins indicated) in C3H10T1/2-derived adipocytes incubated with or without AMPK inhibitor Compound C (CC) (10 μM) for 2 h and followed by HPF treatment for 48 h.

  • 1/16

    Dorsomorphin dihydrochloride purchased from MedChemExpress. Usage Cited in: Life Sci. 2019 Jul 15:229:46-56. [Abstract]

    Customer Validation
     Expression of APOE and COX5A in HUVECs treated with or without rhIL-17A (50 ng/mL) and Compound C (5 μM) is measured by western blot.

  • 1/16

    Dorsomorphin dihydrochloride purchased from MedChemExpress. Usage Cited in: Redox Biol. 2018 Jul;17:180-191. [Abstract]

    Customer Validation
     MDA-MB-231 cells are cultured in poly-HEMA coated dishes and treated with Compound C or GL-V9 for 36 h. The expression of AMPK and p-AMPK in Compound C treated cells are assayed by Western blotting.

  • 1/16

    Dorsomorphin dihydrochloride purchased from MedChemExpress. Usage Cited in: Redox Biol. 2018 Oct;19:339-353. [Abstract]

    Customer Validation
     Western blotting assay of AMPK, p-AMPK, PGC-1α, p-PGC-1α levels in nucleus pulposus (NP) cells stimulated with AGEs (200 μg/mL) in the presence or absence of A-769662 (50 μM), RAGE antibody (10 μg/mL), nicotinamide mononucleotide (NMN, 100 μM) or Compound C (50 uM).

  • 1/16

    Dorsomorphin dihydrochloride purchased from MedChemExpress. Usage Cited in: Biomed Pharmacother. 2018 Oct:106:1390-1395. [Abstract]

    Customer Validation
     Effect of Compound C on cell viability, cell surface area, and apoptosis in Ang II-treated H9c2 cells.

  • 1/16

    Dorsomorphin dihydrochloride purchased from MedChemExpress. Usage Cited in: Biomed Pharmacother. 2018 Oct:106:1390-1395. [Abstract]

    Customer Validation
     Effect of Compound C on the AMPK/Foxo1/miR-143-3p axis in Ang II-treated H9c2 cells.

  • 1/16

    Dorsomorphin dihydrochloride purchased from MedChemExpress. Usage Cited in: Biomed Pharmacother. 2018 Apr:100:417-425. [Abstract]

    Customer Validation
     HaCaT cells are pre-incubated with Compound C (CC) (10 μM) and U0126 (10 μM), pharmacological inhibitors of AMPKα, ERK, respectively, for 1 h before treatment with DA8 and DA14 (DAs).

  • 1/16

    Dorsomorphin dihydrochloride purchased from MedChemExpress. Usage Cited in: J Agric Food Chem. 2018 Nov 7;66(44):11757-11766. [Abstract]

    Customer Validation
     The number of GFP-LC3 dots are reduced significantly after inhibiting STAT3 (AG-490) signaling.

  • 1/16

    Dorsomorphin dihydrochloride purchased from MedChemExpress. Usage Cited in: J Agric Food Chem. 2018 Jul 5;66(26):6772-6781. [Abstract]

    Customer Validation
     Effects of Compound C on capsiate-treated HepG2 cells in high fat environment. The expressions of key metabolic regulators and lipid metabolism-related proteins are quantified by densitometry, and the relative intensities are expressed in the bar chart.

  • 1/16

    Dorsomorphin dihydrochloride purchased from MedChemExpress. Usage Cited in: J Agric Food Chem. 2018 Jul 5;66(26):6772-6781. [Abstract]

    Customer Validation
     Effects of Compound C on capsiate-treated HepG2 cells in high fat environment. The expressions of glucose metabolism-related proteins are quantified by densitometry, and the relative intensities are expressed in the bar chart.

  • 1/16

    Dorsomorphin dihydrochloride purchased from MedChemExpress. Usage Cited in: Int J Mol Med. 2018 May;41(5):2535-2544. [Abstract]

    Customer Validation
     Cells are treated with AICAR and AICAR (A++, 10 μM) + Compound C (C++, 1 μM) for 24 h, after which western blot analysis is performed.

  • 1/16

    Dorsomorphin dihydrochloride purchased from MedChemExpress. Usage Cited in: J Am Heart Assoc. 2018 Jun 12;7(12). pii: e008389. [Abstract]

    Customer Validation
     Representative immunoblots of LC3 in Hippo and cortical brain tissue after CA/CPR. β-Actin serves as a loading control. J, Optical densities of LC3-II and LC3-I protein bands are quantitated. Cc indicates compound C.

  • 1/16

    Dorsomorphin dihydrochloride purchased from MedChemExpress. Usage Cited in: J Am Heart Assoc. 2018 Jun 12;7(12). pii: e008389. [Abstract]

    Customer Validation
     Representative photomicrographs of immunohistochemistry for MAP2, Nissl, Iba-1, and GFAP in the hippocampal CA1 region of the sham-operated, sham-treated with Met (Met-a), and the experimental groups (Veh, Mettreated group, compound C [Cc]–treated group, Met+Cc-treated group, CQ–treated group, and Met+CQ-treated group) at 7 days after return of spontaneous circulation.

  • 1/16

    Dorsomorphin dihydrochloride purchased from MedChemExpress. Usage Cited in: Liver Int. 2018 Dec;38(12):2248-2259. [Abstract]

    Customer Validation
     Cells are treated with 5 μM Dorsomorphin dihydrochloride (Compound C) for 3 hours to inhibit AMPK activity. Next, 2.5 μM CTD is applied for 24 hours. Cells are then collected for apoptosis assays and western blotting.

  • 1/16

    Dorsomorphin dihydrochloride purchased from MedChemExpress. Usage Cited in: Front Pharmacol. 2018 Feb 5:9:68. [Abstract]

    Customer Validation
     CT26 cells are treated with CC for 4 h and detected phosphorylation levels of AMPK.

  • 1/16

    Dorsomorphin dihydrochloride purchased from MedChemExpress. Usage Cited in: Front Pharmacol. 2018 Jul 16:9:761. [Abstract]

    Customer Validation
     Epithelial cells from colon tissue are extracted from mice in each group (n=6-8 per group) and protein level of p-AMPK (Thr172) and AMPKα1/2 are measured by western blot.

  • 1/16

    Dorsomorphin dihydrochloride purchased from MedChemExpress. Usage Cited in: Front Pharmacol. 2018 Aug 29:9:986. [Abstract]

    Customer Validation
     AMPK and p38 phosphorylation is confirmed after Compound C (CC) and SB203580 treatment of Gomisin A (G.A)-treated CT26 cells.

  • 1/16

    Dorsomorphin dihydrochloride purchased from MedChemExpress. Usage Cited in: J Cell Physiol. 2018 May;233(5):3945-3954. [Abstract]

    Customer Validation
     Fraxinellone-prompted phosphorylation of AMPK is blocked by Compound C (CC).

  • 1/16

    Dorsomorphin dihydrochloride purchased from MedChemExpress. Usage Cited in: J Cell Physiol. 2018 Dec;233(12):9701-9715. [Abstract]

    Customer Validation
     HUVECs are pretreated with Compound C (5, 10, or 20 μM) for 18 hr or AICAR (1, 2, or 4 mM) for 1 hr, and then exposed to LSS for 30 min.

  • 1/16

    Dorsomorphin dihydrochloride purchased from MedChemExpress. Usage Cited in: J Immunol Res. 2018 Dec 24:2018:9807139. [Abstract]

    Customer Validation
     Western blot analysis of p-AMPK, AMPK, Bcl2 and Bax, LC3B and P62 expression in liver tissues.

  • 1/16

    Dorsomorphin dihydrochloride purchased from MedChemExpress. Usage Cited in: Acta Biochim Biophys Sin (Shanghai). 2018 Feb 1;50(2):144-155. [Abstract]

    Customer Validation
     Raw264.7 macrophages with serum deprivation are treated with 50 μM Rg1 for 48 h in absence or presence of compound C (10 mM) or AICAR (250 μM). Western blots of the protein expressions of Atg5, Beclin1, LC3, and p62/SQSMT1.

  • 1/16

    Dorsomorphin dihydrochloride purchased from MedChemExpress. Usage Cited in: PLoS One. 2018 Aug 1;13(8):e0200897. [Abstract]

    Customer Validation
     Phosphorylation of AMPK (Thr172) in HTOZ cells pretreated with Compound C at different concentrations (0-20 μM) for 1 hour prior to the presence of norUDCA at 200 μM for additional 1 hour is determined by western blotting analyses.

  • 1/16

    Dorsomorphin dihydrochloride purchased from MedChemExpress. Usage Cited in: Biochem Biophys Res Commun. 2018 Sep 5;503(2):428-435. [Abstract]

    Customer Validation
     Western blotting showing AMPK/m-TOR/ULK1 pathway relative protein (AMPK, p-AMPK, mTOR, p-mTOR, ULK1 and p-ULK1) levels in low glucose (LG), LG+Compound C (CC), HG and HG+CC groups.

  • 1/16

    Dorsomorphin dihydrochloride purchased from MedChemExpress. Usage Cited in: J Cardiovasc Pharmacol. 2018 Oct;72(4):167-175. [Abstract]

    Customer Validation
     Foam cells are incubated with or without Compound C (10 μM) before the addition of CTRP9. According to the Western blot, the relative protein levels of p-AMPK, p-mTOR, LC3 II, and p62 are analyzed, respectively.

  • 1/16

    Dorsomorphin dihydrochloride purchased from MedChemExpress. Usage Cited in: Med Sci Monit. 2018 Jul 25:24:5168-5177. [Abstract]

    Customer Validation
     The levels of p-S6K and S6K in 16HBE cells after treatment of BRL 49653/Troglitazone or/and Compound C are detected by western blot. The levels of p62 and LC3 in 16HBE cells after treatment of BRL 49653/Troglitazone or/and Compound C are detected by western blot.

  • 1/16

    Dorsomorphin dihydrochloride purchased from MedChemExpress. Usage Cited in: Cell Physiol Biochem. 2018;50(5):1891-1902. [Abstract]

    Customer Validation
     AMPK inhibitor dorsomorphin treatment reduces the protein expression of PGC-1α.

  • 1/16

    Dorsomorphin dihydrochloride purchased from MedChemExpress. Usage Cited in: Cell Physiol Biochem. 2018;48(1):227-236. [Abstract]

    Customer Validation
     Inhibition of AMPK with Compound C (CC) attenuates the protective effects of FNDC5 on the oxLDL-induced AMPK dephosphorylation and fibrosis in LX-2 cells.

  • 1/16

    Dorsomorphin dihydrochloride purchased from MedChemExpress. Usage Cited in: Cell Death Dis. 2017 May 18;8(5):e2798. [Abstract]

    Customer Validation
     Involvement of the AMPK/AKT/GSK3β pathway in Nrf2 nuclear translocation by Betulin. Cells are treated with 3 μM compound C (Comp.C) for 18 h before treatment with betulin (36 μM) for 6 h. Cell lysates are immunoblotted for the phosphorylation of AMPK, Akt, GSK3β and Nrf2.

  • 1/16

    Dorsomorphin dihydrochloride purchased from MedChemExpress. Usage Cited in: Biochem Pharmacol. 2017 Aug 15:138:49-60. [Abstract]

    Customer Validation
     Blockade of AMPK signals by AMPK α2 siRNA or AMPK inhibitor (Dorsomorphin; 2.5 μM, pretreatment 2 hours) treatment counteracts the apoptotic effects of Cantharidin at 2.5 μM. Data are representative of at least two independent experiments. Blocking AMPK signaling by knockdown of AMPK or Dorsomorphin (AMPK kinase inhibitor) treatment markedly reverses the apoptotic effect of Cantharidin, indicating that AMPK activation is required for the anti-HCC activity of Cantharidin.

  • 1/16

    Dorsomorphin dihydrochloride purchased from MedChemExpress. Usage Cited in: Am J Chin Med. 2017;45(6):1309-1325. [Abstract]

    Customer Validation
     Activity of MMP-2 and MMP-9 in water extract (WAF)- and ethanol extract (EtAF)-treated CT26 cells after CC (20 μM) pretreatment for 4 h.

  • 1/16

    Dorsomorphin dihydrochloride purchased from MedChemExpress. Usage Cited in: Int J Mol Sci. 2017 May 19;18(5). pii: E1063. [Abstract]

    Customer Validation
     Inhibition of sirt1 and AMPK blocked Rb2-induced hepatic autophagy. HepG2 cells are pretreated with 50 µM Rb2 for 4 h in the presence or absence of the sirt1 inhibitor EX-528 (EX) and the specific AMPK inhibitor Compound C (CC), and then subjected to OA (1 mM for HepG2 and 2 mM for primary mouse hepatocytes) exposure for 12 h. For lipid content determination, intracellular TG are stained by Oil red O (ORO). ORO is then eluted with isopropanol and the optical absorbance of the eluate is measured

  • 1/16

    Dorsomorphin dihydrochloride purchased from MedChemExpress. Usage Cited in: Mol Oncol. 2017 Aug;11(8):1035-1049. [Abstract]

    Customer Validation
     Inhibition of AMPK reverses PD 0332991-induced autophagy and apoptosis. Hep3B cells are incubated with AMPK inhibitor (Compound C, 2.5 μM) for 4 h and then treated with PD 0332991 for 24 h. Apoptotic cells are determined by flow cytometry.

  • 1/16

    Dorsomorphin dihydrochloride purchased from MedChemExpress. Usage Cited in: Free Radic Biol Med. 2016 Dec:101:401-412. [Abstract]

    Customer Validation
     Effect of EsA on AMPK activation is necessary for AKT/GSK3β-mediated Nrf2 activity and cytoprotection. Cells are treated with 3 μM Compound C for 18 h, followed by treatment with EsA for 6 h, and then cell lysates are immunoblotted to assess the phosphorylation of AMPK, Akt and GSK3β and Nrf2.

  • 1/16

    Dorsomorphin dihydrochloride purchased from MedChemExpress. Usage Cited in: Biochem Pharmacol. 2016 Dec 15:122:42-61. [Abstract]

    Customer Validation
     HepG2 cells were incubated with or without Compound C (Dorsomorphin) for 1 h, the cells were switched to medium D in the presence of vehicle, or AHI.

  • 1/16

    Dorsomorphin dihydrochloride purchased from MedChemExpress. Usage Cited in: Oncotarget. 2016 Apr 5;7(14):18085-94. [Abstract]

    Customer Validation
     MACC1 is up-regulated by ACh through p-AMPK. A. ACh stimulates AMPK phosphorylation via M3R. B. Inhibition of AMPK activity by Dorsomorphin (8 μM) suppresses the induction of MACC1 expression by ACh. p-AMPK levels increase after ACh stimulation, and pretreatment of UK-88525 attenuates the ACh-induced increase of p-AMPK.

  • Dorsomorphin dihydrochloride