2. Immunology/Inflammation
  3. COX
  4. COX-2-IN-21

COX-2-IN-21 (Compound 5c) is a selective and orally active COX-2 inhibitor with an IC50 of 0.039 μM. COX-2-IN-21 shows promising anti-inflammatory potential.

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COX-2-IN-21 Chemical Structure

COX-2-IN-21 Chemical Structure

CAS No. : 2519631-11-7

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COX-2-IN-21 Related Antibodies

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Description

COX-2-IN-21 (Compound 5c) is a selective and orally active COX-2 inhibitor with an IC50 of 0.039 μM. COX-2-IN-21 shows promising anti-inflammatory potential[1].

IC50 & Target

COX-2

0.039 μM (IC50)

COX-1

12.4 μM (IC50)

In Vitro

COX-2-IN-21 (Compound 5c) (50 mg/kg) shows better anti-inflammatory activity and is less ulcerogenic than Celecoxib[1].
COX-2-IN-21 (50 mg/kg) displays potent inhibitory effect on the production of PGE2 greater than Celecoxib, decreases rat serum concentrations of both TNF-α (% inhibition = 55.349) and IL-6 (% inhibition = 61.561) in a comparable or better activity to Celecoxib[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

COX-2-IN-21 Related Antibodies
Molecular Weight

422.44

Formula

C21H22N6O4
CAS No.
SMILES

CC(N1N=C(C2=CC=CC(N3N=NN=C3)=C2)CC1C4=CC(OC)=C(OC)C(OC)=C4)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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COX-2-IN-21 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

COX-2-IN-212519631-11-7COXCyclooxygenasePGE2TNF-αIL-6anti-inflammatorycelecoxibInhibitorinhibitorinhibit

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