COX-2-IN-21
COX-2-IN-21 (Compound 5c) is a selective and orally active COX-2 inhibitor with an IC50 of 0.039 μM. COX-2-IN-21 shows promising anti-inflammatory potential.
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- CAS. Nr.: 2519631-11-7
- Formel: C21H22N6O4
- Molecular Weight:422.44
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Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biologische Aktivität
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Chemical Information
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Help & FAQs
Biologische Aktivität
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COX-2 0.039 μM (IC50) |
COX-1 12.4 μM (IC50) |
COX-2-IN-21 (Compound 5c) (50 mg/kg) shows better anti-inflammatory activity and is less ulcerogenic than Celecoxib[1].
COX-2-IN-21 (50 mg/kg) displays potent inhibitory effect on the production of PGE2 greater than Celecoxib, decreases rat serum concentrations of both TNF-α (% inhibition = 55.349) and IL-6 (% inhibition = 61.561) in a comparable or better activity to Celecoxib[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS. Nr. 2519631-11-7
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Molecular Weight 422.44
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Formel C21H22N6O4
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SMILES
CC(N1N=C(C2=CC=CC(N3N=NN=C3)=C2)CC1C4=CC(OC)=C(OC)C(OC)=C4)=O
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Reinheit & Dokumentation
Verweise
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
COX-2-IN-21 Related Classifications
HY-147815 Related Classifications
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