2. Apoptosis
  3. Apoptosis
  4. Anti-inflammatory agent 45

Anti-inflammatory agent 45 (compound 2v) is an anticancer agent with direct inhibitory effects on the growth of different blood cancers including leukemia, lymphoma and myeloma cell lines. Anti-inflammatory agent 45 induces apoptosis and inhibits NO production in HL60 leukemia cells (IC50=14.7 μM).

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Anti-inflammatory agent 45

Anti-inflammatory agent 45 Chemical Structure

CAS No. : 3053681-79-8

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Anti-inflammatory agent 45 Related Antibodies

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Description

Anti-inflammatory agent 45 (compound 2v) is an anticancer agent with direct inhibitory effects on the growth of different blood cancers including leukemia, lymphoma and myeloma cell lines. Anti-inflammatory agent 45 induces apoptosis and inhibits NO production in HL60 leukemia cells (IC50=14.7 μM)[1].

Cellular Effect
Cell Line Type Value Description References
BV-2 IC50
14.7 μM
Compound: 2v
Anti-inflammatory activity against mouse BV-2 cells assessed as inhibition of LPS-induced NO production pretreated for 2 hrs followed stimulated with LPS for 22 hrs by Griess reaction assay
Anti-inflammatory activity against mouse BV-2 cells assessed as inhibition of LPS-induced NO production pretreated for 2 hrs followed stimulated with LPS for 22 hrs by Griess reaction assay
[PMID: 37354740]
BV-2 IC50
9.1 μM
Compound: 2v
Anti-inflammatory activity against mouse BV-2 cells assessed as inhibition of LPS-induced PGE2 production pretreated for 2 hrs followed stimulated with LPS for 22 hrs
Anti-inflammatory activity against mouse BV-2 cells assessed as inhibition of LPS-induced PGE2 production pretreated for 2 hrs followed stimulated with LPS for 22 hrs
[PMID: 37354740]
CCRF-CEM GI50
2.62 μM
Compound: 2v
Anticancer activity against human CCRF-CEM cells assessed as growth inhibition measured after 48 hrs by SRB assay relative to control
Anticancer activity against human CCRF-CEM cells assessed as growth inhibition measured after 48 hrs by SRB assay relative to control
[PMID: 37354740]
HL-60 GI50
1.64 μM
Compound: 2v
Anticancer activity against human HL-60 cells assessed as growth inhibition measured after 48 hrs by SRB assay relative to control
Anticancer activity against human HL-60 cells assessed as growth inhibition measured after 48 hrs by SRB assay relative to control
[PMID: 37354740]
K562 GI50
1.42 μM
Compound: 2v
Anticancer activity against human K562 cells assessed as growth inhibition measured after 48 hrs by SRB assay relative to control
Anticancer activity against human K562 cells assessed as growth inhibition measured after 48 hrs by SRB assay relative to control
[PMID: 37354740]
MOLT-4 GI50
1.63 μM
Compound: 2v
Anticancer activity against human MOLT-4 cells assessed as growth inhibition measured after 48 hrs by SRB assay relative to control
Anticancer activity against human MOLT-4 cells assessed as growth inhibition measured after 48 hrs by SRB assay relative to control
[PMID: 37354740]
RPMI-8226 GI50
1.58 μM
Compound: 2v
Anticancer activity against human RPMI-8226 cells assessed as growth inhibition measured after 48 hrs by SRB assay relative to control
Anticancer activity against human RPMI-8226 cells assessed as growth inhibition measured after 48 hrs by SRB assay relative to control
[PMID: 37354740]
SR GI50
1.34 μM
Compound: 2v
Anticancer activity against human SR cells assessed as growth inhibition measured after 48 hrs by SRB assay relative to control
Anticancer activity against human SR cells assessed as growth inhibition measured after 48 hrs by SRB assay relative to control
[PMID: 37354740]
Molecular Weight

512.35

Formula

C25H22BrNO6
CAS No.
SMILES

BrC1=CC=C(C(NC2=CC(C(C3)OC4=CC(OC)=C(OC)C(OC)=C4C3=O)=CC=C2)=O)C=C1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Anti-inflammatory agent 45 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Anti-inflammatory agent 453053681-79-8ApoptosiscancerleukemialymphomamyelomaInhibitorinhibitorinhibit

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