Bimosiamose disodium
Based on 4 publication(s) in Google Scholar
Bimosiamose disodium (TBC-1269Z) is a nonoligosaccharide pan-selectin inhibitor with IC50s of 88 μM, 20 μM, and 86 μM for E-selectin, P-selectin, and L-selectin, respectively. Bimosiamose disodium has anti-inflammatory effects.
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- CAS. Nr.: 187269-60-9
- Formel: C46H52Na2O16
- Molecular Weight:906.88
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Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
Publications Citing Use of MedChemExpress (MCE) Bimosiamose disodium
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Biologische Aktivität
IC50: 88 μM (E-selectin), 20 μM (P-selectin), and 86 μM (L-selectin)[1]
Bimosiamose (TBC-1269) operates by inhibiting neutrophil recruitment to the site of inflammation through blocking the initial rolling phase of recruitment. Bimosiamose (TBC-1269) inhibits cell recruitment and does not possess any cytotoxic effect on neutrophils[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Sprague-Dawley rats (200-225g) with ischemia and reperfusion (I/R)[1]
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Dosage:25 mg/kg
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Administration:Intravenous injection
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Result:Showed a significant increase in survival compared with controls.
Chemical Information
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CAS. Nr. 187269-60-9
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Molecular Weight 906.88
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Formel C46H52Na2O16
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SMILES
OC[C@H]([C@@H](O)[C@H](O)[C@@H]1O)O[C@@H]1OC(C=C2)=C(C3=CC(CC(O[Na])=O)=CC=C3)C=C2CCCCCCC(C=C4)=CC(C5=CC(CC(O[Na])=O)=CC=C5)=C4O[C@H]6O[C@@H]([C@@H](O)[C@H](O)[C@@H]6O)CO
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Synonyms
TBC-1269Z
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Publications (4)
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Journal Impact Factor
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Most Recent
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Signal Transduct Target Ther
Short-chain acyl-CoA dehydrogenase initiates mtDNA demethylation and leakage to fuel antitumor immunity in colorectal cancer. [Abstract]2026 Mar 26;11(1):113. PMID: 41888107 -
Mar Drugs
Exploring the Inhibitory Effects of Fucosylated Chondroitin Sulfate (FCS) Oligosaccharide Isolated from Stichopus horrens and the Derivatives on P-Selectin. [Abstract]2025 May 30;23(6):236. PMID: 40559645 -
Platelets
Method article: an in vitro blood flow model to advance the study of platelet adhesion utilizing a damaged endothelium. [Abstract]2022 Jul 4;33(5):692-699. PMID: 34927530 -
Reinheit & Dokumentation
Verweise
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)