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Bimosiamose disodium (Synonyms: TBC-1269Z)

Cat. No.: HY-106139A
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Bimosiamose disodium (TBC-1269Z) is a nonoligosaccharide pan-selectin inhibitor with IC50s of 88 μM, 20 μM, and 86 μM for E-selectin, P-selectin, and L-selectin, respectively. Bimosiamose disodium has anti-inflammatory effects.

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Bimosiamose disodium Chemical Structure

Bimosiamose disodium Chemical Structure

CAS No. : 187269-60-9

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Description

Bimosiamose disodium (TBC-1269Z) is a nonoligosaccharide pan-selectin inhibitor with IC50s of 88 μM, 20 μM, and 86 μM for E-selectin, P-selectin, and L-selectin, respectively. Bimosiamose disodium has anti-inflammatory effects[1].

IC50 & Target

IC50: 88 μM (E-selectin), 20 μM (P-selectin), and 86 μM (L-selectin)[1]

In Vitro

Bimosiamose (TBC-1269) operates by inhibiting neutrophil recruitment to the site of inflammation through blocking the initial rolling phase of recruitment. Bimosiamose (TBC-1269) inhibits cell recruitment and does not possess any cytotoxic effect on neutrophils[1].

In Vivo

Bimosiamose (TBC-1269; 25 mg/kg; intravenous injection; Sprague-Dawley rats) treatment shows a significant increase in survival. Best overall survival, 70%, is observed when TBC-1269 is administered 15 minutes before reperfusion, and also shows a marked decrease in liver enzyme levels at 6 hours after reperfusion. Neutrophil migration is also significantly ameliorated (81%). The histologic damage scores is also improved[1].

Animal Model: Sprague-Dawley rats (200-225g) with ischemia and reperfusion (I/R)[1]
Dosage: 25 mg/kg
Administration: Intravenous injection
Result: Showed a significant increase in survival compared with controls.
Clinical Trial
Molecular Weight

906.88

Formula

C₄₆H₅₂Na₂O₁₆

CAS No.

187269-60-9

SMILES

OC[[email protected]]([[email protected]@H](O)[[email protected]](O)[[email protected]@H]1O)O[[email protected]@H]1OC(C=C2)=C(C3=CC(CC(O[Na])=O)=CC=C3)C=C2CCCCCCC(C=C4)=CC(C5=CC(CC(O[Na])=O)=CC=C5)=C4O[[email protected]]6O[[email protected]@H]([[email protected]@H](O)[[email protected]](O)[[email protected]@H]6O)CO

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Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

Bimosiamose disodiumTBC-1269ZOthersP-selectinE-selectinL-selectinischemiareperfusionanti-inflammatoryneutrophilmigrationnonoligosaccharideInhibitorinhibitorinhibit

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