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Bimosiamose (Synonyms: TBC-1269)

Cat. No.: HY-106139 Purity: 99.33%
Handling Instructions

Bimosiamose (TBC-1269) is a nonoligosaccharide pan-selectin antagonist with IC50s of 88 μM, 20 μM, and 86 μM for E-selectin, P-selectin, and L-selectin, respectively. Bimosiamose has anti-inflammatory effects.

For research use only. We do not sell to patients.

Bimosiamose Chemical Structure

Bimosiamose Chemical Structure

CAS No. : 187269-40-5

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10 mM * 1 mL in DMSO USD 342 In-stock
Estimated Time of Arrival: December 31
1 mg USD 60 In-stock
Estimated Time of Arrival: December 31
5 mg USD 180 In-stock
Estimated Time of Arrival: December 31
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Customer Review

Based on 1 publication(s) in Google Scholar

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Description

Bimosiamose (TBC-1269) is a nonoligosaccharide pan-selectin antagonist with IC50s of 88 μM, 20 μM, and 86 μM for E-selectin, P-selectin, and L-selectin, respectively. Bimosiamose has anti-inflammatory effects[1].

IC50 & Target

IC50: 88 μM (E-selectin), 20 μM (P-selectin), 86 μM (L-selectin)[1]

In Vitro

Bimosiamose (TBC-1269) operates by inhibiting neutrophil recruitment to the site of inflammation through blocking the initial rolling phase of recruitment. Bimosiamose (TBC-1269) inhibits cell recruitment and does not possess any cytotoxic effect on neutrophils[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Bimosiamose (TBC-1269; 25 mg/kg; intravenous injection; Sprague-Dawley rats) treatment shows a significant increase in survival. Best overall survival, 70%, is observed when TBC-1269 is administered 15 minutes before reperfusion, and also shows a marked decrease in liver enzyme levels at 6 hours after reperfusion. Neutrophil migration is also significantly ameliorated (81%). The histologic damage scores is also improved[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Sprague-Dawley rats (200-225g) with ischemia and reperfusion (I/R)[1]
Dosage: 25 mg/kg
Administration: Intravenous injection
Result: Showed a significant increase in survival compared with controls.
Clinical Trial
Molecular Weight

862.91

Formula

C₄₆H₅₄O₁₆

CAS No.

187269-40-5

SMILES

OC[[email protected]]([[email protected]@H](O)[[email protected]](O)[[email protected]@H]1O)O[[email protected]@H]1OC(C=C2)=C(C3=CC(CC(O)=O)=CC=C3)C=C2CCCCCCC(C=C4)=CC(C5=CC(CC(O)=O)=CC=C5)=C4O[[email protected]]6O[[email protected]@H]([[email protected]@H](O)[[email protected]](O)[[email protected]@H]6O)CO

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 125 mg/mL (144.86 mM; Need ultrasonic)

0.1 M NaOH : 25 mg/mL (28.97 mM; ultrasonic and adjust pH to 10 with NaOH)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.1589 mL 5.7943 mL 11.5887 mL
5 mM 0.2318 mL 1.1589 mL 2.3177 mL
10 mM 0.1159 mL 0.5794 mL 1.1589 mL
*Please refer to the solubility information to select the appropriate solvent.
References

Purity: 99.33%

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Keywords:

BimosiamoseTBC-1269TBC1269TBC 1269OthersP-selectinE-selectinL-selectinischemiareperfusionanti-inflammatoryneutrophilmigrationnonoligosaccharideInhibitorinhibitorinhibit

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Bimosiamose
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