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Bimosiamose (Synonyms: TBC 1269)

Cat. No.: HY-106139
Handling Instructions

Bimosiamose is a pan-selectin antagonist, inhibits E-, P-, and L-selectin with IC50s of 88 μM, 20 μM, and 86 μM, respectively, and can be used in the research of inflammatory disease.

For research use only. We do not sell to patients.

Bimosiamose Chemical Structure

Bimosiamose Chemical Structure

CAS No. : 187269-40-5

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  • Biological Activity

  • Technical Information

  • Purity & Documentation

  • References

Description

Bimosiamose is a pan-selectin antagonist, inhibits E-, P-, and L-selectin with IC50s of 88 μM, 20 μM, and 86 μM, respectively, and can be used in the research of inflammatory disease.

IC50 & Target

IC50: 88 μM (E-selectin), 20 μM (P-selectin), 86 μM (L-selectin)[1]

In Vitro

Bimosiamose is a pan-selectin antagonist, inhibits E-, P-, and L-selectin with IC50s of 88 μM, 20 μM, and 86 μM, respectively, and can be used in the research of inflammatory disease[1].

In Vivo

Bimosiamose (25 mg/kg, i.v.) significantly improves the survival in rats subjected to severe hepatic ischemia and reperfusion. Bimosiamose also causes lower ALT enzyme levels and decreases neutrophil infiltration[1].

Clinical Trial
Solvent & Solubility
In Vitro: 

10 mM in DMSO

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.1589 mL 5.7943 mL 11.5887 mL
5 mM 0.2318 mL 1.1589 mL 2.3177 mL
10 mM 0.1159 mL 0.5794 mL 1.1589 mL
*Please refer to the solubility information to select the appropriate solvent.
References
Molecular Weight

862.91

Formula

C₄₆H₅₄O₁₆

CAS No.

187269-40-5

SMILES

OC[[email protected]]([[email protected]@H](O)[[email protected]](O)[[email protected]@H]1O)O[[email protected]@H]1OC(C=C2)=C(C3=CC(CC(O)=O)=CC=C3)C=C2CCCCCCC(C=C4)=CC(C5=CC(CC(O)=O)=CC=C5)=C4O[[email protected]]6O[[email protected]@H]([[email protected]@H](O)[[email protected]](O)[[email protected]@H]6O)CO

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Shipping

Room temperature in continental US; may vary elsewhere

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Product Name:
Bimosiamose
Cat. No.:
HY-106139
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Bimosiamose

Cat. No.: HY-106139