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Bimosiamose (Synonyms: TBC 1269)

Cat. No.: HY-106139
Handling Instructions

Bimosiamose is a pan-selectin antagonist, inhibits E-, P-, and L-selectin with IC50s of 88 μM, 20 μM, and 86 μM, respectively, and can be used in the research of inflammatory disease.

For research use only. We do not sell to patients.

Bimosiamose Chemical Structure

Bimosiamose Chemical Structure

CAS No. : 187269-40-5

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Description

Bimosiamose is a pan-selectin antagonist, inhibits E-, P-, and L-selectin with IC50s of 88 μM, 20 μM, and 86 μM, respectively, and can be used in the research of inflammatory disease.

IC50 & Target

IC50: 88 μM (E-selectin), 20 μM (P-selectin), 86 μM (L-selectin)[1]

In Vitro

Bimosiamose is a pan-selectin antagonist, inhibits E-, P-, and L-selectin with IC50s of 88 μM, 20 μM, and 86 μM, respectively, and can be used in the research of inflammatory disease[1].

In Vivo

Bimosiamose (25 mg/kg, i.v.) significantly improves the survival in rats subjected to severe hepatic ischemia and reperfusion. Bimosiamose also causes lower ALT enzyme levels and decreases neutrophil infiltration[1].

Clinical Trial
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
Molecular Weight

862.91

Formula

C₄₆H₅₄O₁₆

CAS No.

187269-40-5

SMILES

OC[[email protected]]([[email protected]@H](O)[[email protected]](O)[[email protected]@H]1O)O[[email protected]@H]1OC(C=C2)=C(C3=CC(CC(O)=O)=CC=C3)C=C2CCCCCCC(C=C4)=CC(C5=CC(CC(O)=O)=CC=C5)=C4O[[email protected]]6O[[email protected]@H]([[email protected]@H](O)[[email protected]](O)[[email protected]@H]6O)CO

Shipping

Room temperature in continental US; may vary elsewhere

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Bimosiamose

Cat. No.: HY-106139