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Gemcabene calcium (Synonyms: PD-72953 calcium)

Cat. No.: HY-109567A Purity: >98.0%
Handling Instructions

Gemcabene calcium (PD-72953 calcium), a first-in-class lipid-lowering agent, lowers low-density lipoprotein cholesterol (LDL-C), decreases triglycerides, and raises high-density lipoprotein cholesterol (HDL-C) and lowers pro-inflammatory acute-phase protein, C-reactive protein (CRP), exerting anti-inflammatory activity.

For research use only. We do not sell to patients.

Gemcabene calcium Chemical Structure

Gemcabene calcium Chemical Structure

CAS No. : 209789-08-2

Size Price Stock Quantity
10 mM * 1 mL in Water USD 385 In-stock
Estimated Time of Arrival: December 31
5 mg USD 350 In-stock
Estimated Time of Arrival: December 31
10 mg USD 550 In-stock
Estimated Time of Arrival: December 31
50 mg USD 1650 In-stock
Estimated Time of Arrival: December 31
100 mg USD 2650 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

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Customer Review

Based on 1 publication(s) in Google Scholar

Other Forms of Gemcabene calcium:

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Description

Gemcabene calcium (PD-72953 calcium), a first-in-class lipid-lowering agent, lowers low-density lipoprotein cholesterol (LDL-C), decreases triglycerides, and raises high-density lipoprotein cholesterol (HDL-C) and lowers pro-inflammatory acute-phase protein, C-reactive protein (CRP), exerting anti-inflammatory activity[1][2][3].

In Vitro

Gemcabene calcium (PD-72953 calcium) significantly downregulates hepatic mRNA markers of inflammation (TNF-α, MCP-1, MIP-1β, CCR5, CCR2, NF-κB), lipogenesis and lipid modulation (ApoC-III, ACC1, ADH-4, Sulf-2), and fibrosis (TIMP-1 and MMP-2)[3].

Molecular Weight

340.47

Formula

C₁₆H₂₈CaO₅

CAS No.

209789-08-2

SMILES

O=C([O-])C(C)(C)CCCCOCCCCC(C)(C([O-])=O)C.[Ca+2]

Shipping

Room temperature in continental US; may vary elsewhere

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

H2O : 10 mg/mL (29.37 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.9371 mL 14.6856 mL 29.3712 mL
5 mM 0.5874 mL 2.9371 mL 5.8742 mL
10 mM 0.2937 mL 1.4686 mL 2.9371 mL
*Please refer to the solubility information to select the appropriate solvent.
References

Purity: >98.0%

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Gemcabene calcium
Cat. No.:
HY-109567A
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