209789-08-2
Chemical Structure
Gemcabene calcium
Synonym(s): PD-72953 calcium
- CAS No.: 209789-08-2
- Formula:C16H28CaO5
- Molecular Weight:340.47
IUPAC Name: calcium 6,6'-oxybis(2,2-dimethylhexanoate)
InChIKey: ZJKZKKPIKDNHDM-UHFFFAOYSA-L
SMILES: O=C([O-])C(C)(C)CCCCOCCCCC(C)(C([O-])=O)C.[Ca+2]
Biological Activity: Gemcabene calcium (PD-72953 calcium), a first-in-class lipid-lowering agent, lowers low-density lipoprotein cholesterol (LDL-C), decreases triglycerides, and raises high-density lipoprotein cholesterol (HDL-C) and lowers pro-inflammatory acute-phase protein, C-reactive protein (CRP), exerting anti-inflammatory activity[1][2][3].
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Gemcabene calcium | 98.0% | Gemcabene calcium (PD-72953 calcium), a first-in-class lipid-lowering agent, lowers low-density lipoprotein cholesterol (LDL-C), decreases triglycerides, and raises high-density lipoprotein cholesterol (HDL-C) and lowers pro-inflammatory acute-phase protein, C-reactive protein (CRP), exerting anti-inflammatory activity. | ||||||||||||||||||||
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- [1]. Mandema JW, et al. Model-based development of gemcabene, a new lipid-altering agent. AAPS J. 2005 Oct 7;7(3):E513-22. [Content Brief]
- [2]. Srivastava RAK, et al. Gemcabene, a First-in-Class Hypolipidemic Small Molecule in Clinical Development, Attenuates Osteoarthritis and Pain in Animal Models of Arthritis and Pain. Front Pharmacol. 2018 May 11;9:471. [Content Brief]
- [3]. Oniciu DC, et al. Gemcabene downregulates inflammatory, lipid-altering and cell-signaling genes in the STAM™ model of NASH. PLoS One. 2018 May 30;13(5):e0194568. [Content Brief]
Keywords
