1. Anti-infection Stem Cell/Wnt JAK/STAT Signaling
  2. Antibiotic STAT
  3. Corylin

Corylin 

Cat. No.: HY-N0236 Purity: 99.97%
COA Handling Instructions

Corylin is an orally active flavonoid anti-inflammatory and osteogenic agent that inhibits IL-6-induced STAT3 promoter activity and STAT3 phosphorylation. Corylin also has anticancer, antiatherosclerotic, and ameliorating activity in hyperlipidemia and insulin resistance, inducing adipocyte browning and lipolysis through SIRT1 or β3-AR-dependent pathways.

For research use only. We do not sell to patients.

Corylin Chemical Structure

Corylin Chemical Structure

CAS No. : 53947-92-5

Size Price Stock Quantity
Solid + Solvent
10 mM * 1 mL in DMSO
ready for reconstitution
USD 106 In-stock
Solution
10 mM * 1 mL in DMSO USD 106 In-stock
Solid
5 mg USD 96 In-stock
10 mg USD 132 In-stock
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100 mg   Get quote  

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Customer Review

Based on 4 publication(s) in Google Scholar

Top Publications Citing Use of Products
  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

Corylin is an orally active flavonoid anti-inflammatory and osteogenic agent that inhibits IL-6-induced STAT3 promoter activity and STAT3 phosphorylation. Corylin also has anticancer, antiatherosclerotic, and ameliorating activity in hyperlipidemia and insulin resistance, inducing adipocyte browning and lipolysis through SIRT1 or β3-AR-dependent pathways[1][2][3].

In Vitro

Corylin (3-300 µM, 0-72 h) inhibits the proliferation of HepG2 and Huh7 cells[2].
Corylin (3-30 µM, 0-48 h) inhibits the migration and invasiveness of HepG2 and Huh7 cells by suppressing EMT[2].
Corylin (5-200 µM, 24 h) reduces the viability of 3T3-L1 preadipocytes at the doses of 100-200 µM[3].
Corylin (10 µM, 24 h) induces browning via the SIRT1 and β3-AR pathways in 3T3-L1 adipocytes[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Western Blot Analysis[2]

Cell Line: HepG2 and Huh7 cells
Concentration: 3-30 µM
Incubation Time: 24-48 h
Result: Reduced the expression of EMT-promoting proteins such as N-cadherin, vimentin, slug, and twist.
In Vivo

Corylin (60 mg/kg, i.p., three times a week, 4 weeks) inhibits tumor growth in Huh7 cells xenograft mice[3].
Corylin (50-100 mg/kg, p.o., daily, 9 weeks) improves the high-fat diet (HFD)-induced obesity in HFD- and DIO-treated mice[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: HFD- and DIO-treated mice[3]
Dosage: 50-100 mg/kg
Administration: Oral gavage (p.o.), daily, 9 weeks
Result: Reduced the weight of subcutaneous, visceral WAT, and body.
Decreased the size of WAT adipocyte.
Increased insulin sensitivity, mitochondrial biogenesis, and β-oxidation.
Reduced serum levels of insulin and leptin and improved HOMA-IR.
Molecular Weight

320.34

Formula

C20H16O4

CAS No.
Appearance

Solid

Color

White to light yellow

SMILES

O=C1C(C2=CC=C3C(C=CC(C)(C)O3)=C2)=COC4=CC(O)=CC=C14

Structure Classification
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility
In Vitro: 

DMSO : ≥ 100 mg/mL (312.17 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.1217 mL 15.6084 mL 31.2168 mL
5 mM 0.6243 mL 3.1217 mL 6.2434 mL
10 mM 0.3122 mL 1.5608 mL 3.1217 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    90% Corn Oil

    Solubility: ≥ 2.5 mg/mL (7.80 mM); Clear solution

*All of the co-solvents are available by MedChemExpress (MCE).
Purity & Documentation

Purity: 99.97%

References
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Corylin
Cat. No.:
HY-N0236
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