2. Anti-infection Stem Cell/Wnt JAK/STAT Signaling
  3. Antibiotic STAT
  4. Corylin

Corylin is an orally active flavonoid anti-inflammatory and osteogenic agent that inhibits IL-6-induced STAT3 promoter activity and STAT3 phosphorylation. Corylin also has anticancer, antiatherosclerotic, and ameliorating activity in hyperlipidemia and insulin resistance, inducing adipocyte browning and lipolysis through SIRT1 or β3-AR-dependent pathways.

For research use only. We do not sell to patients.

CAS No. : 53947-92-5

Size Price Stock Quantity
Free Sample (0.1 - 0.2 mg)   Apply Now  
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
 In-stock
Solution
10 mM * 1 mL in DMSO In-stock
Solid
5 mg In-stock
10 mg In-stock
25 mg In-stock
50 mg In-stock
100 mg In-stock
200 mg   Get quote  
500 mg   Get quote  

* Please select Quantity before adding items.

This product is a controlled substance and not for sale in your territory.

Customer Review

Based on 9 publication(s) in Google Scholar

Other Forms of Corylin:

Corylin Related Antibodies

Top Publications Citing Use of Products

    Corylin purchased from MedChemExpress. Usage Cited in: Phytomedicine. 2026 May:154:158029.  [Abstract]

    Cell viability of Arnicolide D, Corylin, Demethyleneberberine and Hirsuteine against GC cells, as evaluated by the CCK8 assays.

    Corylin purchased from MedChemExpress. Usage Cited in: Cell Rep Med. 2022 May 17;3(5):100608.  [Abstract]

    Corylin (1 μM) and enzalutamide synergistically inhibited DHEA- but not DHT-induced gene expression in VCaP-Enz cells. DHEA, 100 nM; DHT, 1 nM.

    Corylin purchased from MedChemExpress. Usage Cited in: Cell Rep Med. 2022 May 17;3(5):100608.  [Abstract]

    Corylin (5 μM) and enzalutamide synergistically inhibited DHEA- but not DHT-induced cell growth in VCaP-Enz cells. DHEA, 200 nM; DHT, 1 nM.

    Corylin purchased from MedChemExpress. Usage Cited in: Cell Rep Med. 2022 May 17;3(5):100608.  [Abstract]

    Daidzein inhibited abiraterone metabolism in VCaP and Huh7 cells, although not as potently as corylin and BCA.

    Corylin purchased from MedChemExpress. Usage Cited in: Phytomedicine. 2023 Feb:110:154627.  [Abstract]

    Effects of different doses of Corylin (0-20 μM) on NF-κB luciferase reporter stimulated by TNF-α.

    View All Antibiotic Isoform Specific Products:

    View All Isoforms
    Aminoglycoside Glycopeptide Lipopeptide Macrolide Oxazolidinone Quinolone Tetracycline β-lactam

    View All STAT Isoform Specific Products:

    View All Isoforms
    STAT3 STAT5 STAT6 STAT1

    • Biological Activity

    • Purity & Documentation

    • References

    • Customer Review

    Description

    Corylin is an orally active flavonoid anti-inflammatory and osteogenic agent that inhibits IL-6-induced STAT3 promoter activity and STAT3 phosphorylation. Corylin also has anticancer, antiatherosclerotic, and ameliorating activity in hyperlipidemia and insulin resistance, inducing adipocyte browning and lipolysis through SIRT1 or β3-AR-dependent pathways[1][2][3].

    In Vitro

    Corylin (3-300 µM, 0-72 h) inhibits the proliferation of HepG2 and Huh7 cells[2].
    Corylin (3-30 µM, 0-48 h) inhibits the migration and invasiveness of HepG2 and Huh7 cells by suppressing EMT[2].
    Corylin (5-200 µM, 24 h) reduces the viability of 3T3-L1 preadipocytes at the doses of 100-200 µM[3].
    Corylin (10 µM, 24 h) induces browning via the SIRT1 and β3-AR pathways in 3T3-L1 adipocytes[3].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    Corylin Related Antibodies

    Western Blot Analysis[2]

    Cell Line: HepG2 and Huh7 cells
    Concentration: 3-30 µM
    Incubation Time: 24-48 h
    Result: Reduced the expression of EMT-promoting proteins such as N-cadherin, vimentin, slug, and twist.
    In Vivo

    Corylin (60 mg/kg, i.p., three times a week, 4 weeks) inhibits tumor growth in Huh7 cells xenograft mice[3].
    Corylin (50-100 mg/kg, p.o., daily, 9 weeks) improves the high-fat diet (HFD)-induced obesity in HFD- and DIO-treated mice[3].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    Animal Model: HFD- and DIO-treated mice[3]
    Dosage: 50-100 mg/kg
    Administration: Oral gavage (p.o.), daily, 9 weeks
    Result: Reduced the weight of subcutaneous, visceral WAT, and body.
    Decreased the size of WAT adipocyte.
    Increased insulin sensitivity, mitochondrial biogenesis, and β-oxidation.
    Reduced serum levels of insulin and leptin and improved HOMA-IR.
    Molecular Weight

    320.34

    Formula

    C20H16O4
    CAS No.
    Appearance

    Solid

    Color

    White to light yellow

    SMILES

    O=C1C(C2=CC=C3C(C=CC(C)(C)O3)=C2)=COC4=CC(O)=CC=C14
    Structure Classification
    Initial Source
    Shipping

    Room temperature in continental US; may vary elsewhere.
    Storage

    4°C, protect from light

    *In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

    Solvent & Solubility
    In Vitro: 

    DMSO : ≥ 100 mg/mL (312.17 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

    *"≥" means soluble, but saturation unknown.

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 3.1217 mL 15.6084 mL 31.2168 mL
    5 mM 0.6243 mL 3.1217 mL 6.2434 mL
    View the Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

    • Molarity Calculator

    • Dilution Calculator

    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

    Mass
    =
    Concentration
    ×
    Volume
    ×
    Molecular Weight *

    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    This equation is commonly abbreviated as: C1V1 = C2V2

    Concentration (start)

    C1

    ×
    Volume (start)

    V1

    =
    Concentration (final)

    C2

    ×
    Volume (final)

    V2

    In Vivo:

    Select the appropriate dissolution method based on your experimental animal and administration route.

    For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
    To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
    The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

    • Protocol 1

      Add each solvent one by one:  10% DMSO    90% Corn Oil

      Solubility: ≥ 2.5 mg/mL (7.80 mM); Clear solution

      This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.

      Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL Corn oil, and mix evenly.

    For the following dissolution methods, please prepare the working solution directly. It is recommended to prepare fresh solutions and use them promptly within a short period of time.
    The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

    • Protocol 1

      Add each solvent one by one:  0.5% CMC-Na/saline water

      Solubility: 25 mg/mL (78.04 mM); Suspended solution; Need ultrasonic

    • Protocol 2

      Add each solvent one by one:  15% Cremophor EL    85% Saline

      Solubility: 50 mg/mL (156.08 mM); Suspended solution; Need ultrasonic

    In Vivo Dissolution Calculator
    Please enter the basic information of animal experiments:

    Dosage

    mg/kg

    Animal weight
    (per animal)

    g

    Dosing volume
    (per animal)

    μL

    Number of animals

    Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
    Please enter your animal formula composition:
    %
    DMSO +
    % 
    +
    %
    Tween-80 +
    %
    Saline
    Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
    The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
    Calculation results:
    Working solution concentration: mg/mL
    Method for preparing stock solution: mg drug dissolved in μL  DMSO (Stock solution concentration: mg/mL).

    *In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

    The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).
    Method for preparing in vivo working solution for animal experiments: Take μL DMSO stock solution, add μL . μL , mix evenly, next add μL Tween 80, mix evenly, then add μL Saline.
     If the continuous dosing period exceeds half a month, please choose this protocol carefully.
    Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
    Purity & Documentation

    Purity: 99.97%

    SDS (393 KB)

    COA (246 KB) HNMR (257 KB) RP-HPLC (245 KB) MS (69 KB)

    Handling Instructions (2659 KB)
    References

    Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

    Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
    DMSO 1 mM 3.1217 mL 15.6084 mL 31.2168 mL 78.0421 mL
    5 mM 0.6243 mL 3.1217 mL 6.2434 mL 15.6084 mL
    10 mM 0.3122 mL 1.5608 mL 3.1217 mL 7.8042 mL
    15 mM 0.2081 mL 1.0406 mL 2.0811 mL 5.2028 mL
    20 mM 0.1561 mL 0.7804 mL 1.5608 mL 3.9021 mL
    25 mM 0.1249 mL 0.6243 mL 1.2487 mL 3.1217 mL
    30 mM 0.1041 mL 0.5203 mL 1.0406 mL 2.6014 mL
    40 mM 0.0780 mL 0.3902 mL 0.7804 mL 1.9511 mL
    50 mM 0.0624 mL 0.3122 mL 0.6243 mL 1.5608 mL
    60 mM 0.0520 mL 0.2601 mL 0.5203 mL 1.3007 mL
    80 mM 0.0390 mL 0.1951 mL 0.3902 mL 0.9755 mL
    100 mM 0.0312 mL 0.1561 mL 0.3122 mL 0.7804 mL
    • No file chosen (Maximum size is: 1024 Kb)
    • If you have published this work, please enter the PubMed ID.
    • Your name will appear on the site.

    Corylin Related Classifications

    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    Corylin53947-92-5AntibioticSTATFlavonoidorally activeanti-inflammatoryosteogenicanticancerantiatherosclerotichyperlipidemiainsulinInhibitorinhibitorinhibit

    Your Recently Viewed Products:

    Inquiry Online

    Your information is safe with us. * Required Fields.

    Product Name

    		  

    Requested Quantity *

    Applicant Name *

    		 

    Salutation

    Email Address *

    		 

    Phone Number *

    Department

    		 

    Organization Name *

    City

    State

    Country or Region *

    		      

    Remarks

    Bulk Inquiry

    Inquiry Information

    Product Name:
    Corylin
    Cat. No.:
    HY-N0236
    Quantity:
    MCE Japan Authorized Agent:

    Customer Review

    Thank You for Your Feedback!

    Request for HNMR Report

    Please fill out this form to request the QC report. We will send it to your Email address shortly.

    Your information is safe with us. * Required Fields.

    Product Name

    		  

    Lot #

    Applicant Name *

    		 

    Email Address *

    Phone Number

    		 

    Department *

    Organization Name *

    		 

    Country or Region *

    Remarks

    SAFETY DATA SHEET (SDS)

    English - EN (393 KB) Français - FR (393 KB) Deutsch - DE (393 KB) Norwegian - NO (393 KB) Español - ES (393 KB) Swedish - SV (393 KB) Italian - IT (393 KB) Korean - KR (393 KB) Portuguese - PT (393 KB)

    Request for HNMR Report

    We have received your request and will respond to you as soon as possible.