1. GPCR/G Protein
    Immunology/Inflammation
    NF-κB
  2. CCR
    NF-κB
  3. 7,4'-Dihydroxyflavone

7,4'-Dihydroxyflavone 

Cat. No.: HY-N2609
Handling Instructions

7,4'-Dihydroxyflavone (7,4'-DHF) is a flavonoid isolated from Glycyrrhiza uralensis, the eotaxin/CCL11 inhibitor, has the ability to consistently suppress eotaxin production and prevent dexamethasone (Dex)‐paradoxical adverse effects on eotaxin production. 7,4'-Dihydroxyflavone (7,4'-DHF) inhibits MUC5AC gene expression, mucus production and secretion via regulation of NF-κB, STAT6 and HDAC2. 7,4'-Dihydroxyflavone (7,4'-DHF) decreases phorbol 12-myristate 13-acetate (PMA) stimulated NCI-H292 human airway epithelial cell MUC5AC gene expression and mucus production with IC50 value of 1.4 µM.

For research use only. We do not sell to patients.

7,4'-Dihydroxyflavone Chemical Structure

7,4'-Dihydroxyflavone Chemical Structure

CAS No. : 2196-14-7

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Description

7,4'-Dihydroxyflavone (7,4'-DHF) is a flavonoid isolated from Glycyrrhiza uralensis, the eotaxin/CCL11 inhibitor, has the ability to consistently suppress eotaxin production and prevent dexamethasone (Dex)‐paradoxical adverse effects on eotaxin production[1]. 7,4'-Dihydroxyflavone (7,4'-DHF) inhibits MUC5AC gene expression, mucus production and secretion via regulation of NF-κB, STAT6 and HDAC2. 7,4'-Dihydroxyflavone (7,4'-DHF) decreases phorbol 12-myristate 13-acetate (PMA) stimulated NCI-H292 human airway epithelial cell MUC5AC gene expression and mucus production with IC50 value of 1.4 µM[1].

IC50 & Target

IC50: 1.4 μM (NCI-H292 human airway epithelial cell) (7,4'-Dihydroxyflavone)[2]

Molecular Weight

254.24

Formula

C₁₅H₁₀O₄

CAS No.

2196-14-7

SMILES

O=C1C=C(C2=CC=C(O)C=C2)OC3=CC(O)=CC=C13

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Room temperature in continental US; may vary elsewhere

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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7,4'-Dihydroxyflavone
Cat. No.:
HY-N2609
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