1. GPCR/G Protein
    Neuronal Signaling
  2. Sigma Receptor
  3. SR-31747 free base

SR-31747 free base 

Cat. No.: HY-13751A Purity: 95.45%
Handling Instructions

SR-31747 free base is a sigma ligand with immunosuppressive and anti-inflammatory properties. SR-31747 blocks cell proliferation by inhibiting sterol isomerase.

For research use only. We do not sell to patients.

SR-31747 free base Chemical Structure

SR-31747 free base Chemical Structure

CAS No. : 132173-06-9

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10 mg USD 550 Ask For Quote & Lead Time
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50 mg USD 1650 Ask For Quote & Lead Time

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Description

SR-31747 free base is a sigma ligand with immunosuppressive and anti-inflammatory properties. SR-31747 blocks cell proliferation by inhibiting sterol isomerase[1][2].

IC50 & Target

Sigma ligand[1]

In Vitro

SR-31747 blocks the proliferation of lymphocytes at a concentration of 10 nM. SR-31747 is capable of inhibiting T-cell proliferation when added as late as 24 h after activation. SR-31747 arrests proliferation in yeast cells in a dose-dependent manner[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

In vivo, SR-31747 dramatically blocks lipopolysaccharide-induced production of IL-1, IL-6 and TNF-α in a dose-dependent manner (ED50, 2 mg/kg). SR-31747 probably abrogated monokine production through an indirect mechanism that involves endogenous corticosteroids. This conclusion was supported by in vivo experiments that shows that: 1) ablation of corticosteroids by use of Mifepristone or adrenalectomy suppress the effect of SR-31747; 2) administration of SR-31747 induces an enhancement of the corticosterone level. SR-31747 improves the survival of animals with endotoxinic shock as a result of monokine inhibition[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

359.98

Formula

C₂₃H₃₄ClN

CAS No.

132173-06-9

SMILES

CCN(C/C=C\C1=CC=C(C2CCCCC2)C(Cl)=C1)C3CCCCC3

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Pure form -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 5 mg/mL (13.89 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.7779 mL 13.8897 mL 27.7793 mL
5 mM 0.5556 mL 2.7779 mL 5.5559 mL
10 mM 0.2778 mL 1.3890 mL 2.7779 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 0.5 mg/mL (1.39 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 0.5 mg/mL (1.39 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 0.5 mg/mL (1.39 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
Animal Administration
[1]

IL-1, IL-6 and TNF-a are induced by i.p. injection of LPS into BALBIc mice. SR 31747 or reference substances are administered i.p. at the indicated doses together with LPS (0.5 mg/kg). Control animals are treated with LPS and vehicle. Blood samples are collected from the retro-orbital sinus 1 hr or 4 hr after LPS injection for the determination of TNF-α, IL-1 and IL-6. Plasma is prepared and stored frozen until experiments. The IL-1 plasma level is determined by a competitive radioreceptor assay with the use of the murine NOBEL4 cell line and [125I]-IL-1. The IL-6 assay is conducted with the B9 murine IL-6-dependent cell line. The TNF-a plasma level is evaluated by the cytolytic assay with the dactinomycin-treated LM6 cell line, derived from the murine fibroblastic L929 cell line. Each determination is performed on a pool of three different plasma samples. None of the molecules administered affect these assays even at the highest dose (10-5 M), which thereby rules out the possibility of any direct effect caused by the presence ofdrugs in treated-animal sera. In the various tests, one unit is defined as the amount of cytokines able to induce 50% of the maximal effect.

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

References

Purity: 95.45%

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Keywords:

SR-31747SR31747SR 31747Sigma ReceptorImmunosuppressiveIL-1IL-6TNF-αcorticosteroneanti-inflammatoryT-cellanti-proliferationsterolisomeraseInhibitorinhibitorinhibit

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SR-31747 free base
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