2. Anti-infection
  3. HSV
  4. Lactoferrin

Lactoferrin is a substance released by neutrophils. Lactoferrin is an orally active multifunctional iron binding glycoprotein. Lactoferrin prevents cell adhesion, growth and spreading of cell colonies. Lactoferrin also has antiviral activity and inhibits microbial and viral adhesion and entry into host cells. Besides, Lactoferrin has anti-inflammatory, immunomodulatory, and anti-cancer activities.

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Lactoferrin Chemical Structure

Lactoferrin Chemical Structure

CAS No. : 936541-36-5

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Lactoferrin Related Antibodies

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Description

Lactoferrin is a substance released by neutrophils. Lactoferrin is an orally active multifunctional iron binding glycoprotein. Lactoferrin prevents cell adhesion, growth and spreading of cell colonies. Lactoferrin also has antiviral activity and inhibits microbial and viral adhesion and entry into host cells. Besides, Lactoferrin has anti-inflammatory, immunomodulatory, and anti-cancer activities[1][2][3].

In Vitro

Lactoferrin (0-1 000 μg/mL, 7 days) inhibits epithelial cell (HaCaT) growth in a dose-dependent manner[1].
Lactoferrin (500 μg/mL, 12 days) inhibits the spreading and growth of HaCaT cell colonies[1].
Lactoferrin (1.41 μM and 0.12 μM for human and bovine Lactoferrins) inhibits HSV-1 infection in vero cells by 50%[4].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Lactoferrin Related Antibodies
In Vivo

Lactoferrin (recombinant human lactoferrin) (1,000 mg/kg, oral gavage, twice daily for 8 days) inhibits the growth of squamous cell carcinoma (O12) tumors in T cell–immunocompromised nu/nu mice by 80%[5].
Lactoferrin (Bovine lactoferrin) (100 and 200 mg/kg, oral gavage,for 30 consecutive days) shows protective effects in a rat model of sepsis-induced acute lung injury[6].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Squamous cell carcinoma model (O12 cell injected into the left flank of nu/numice)[5]
Dosage: 1,000 mg/kg
Administration: oral gavage, twice daily for 8 days
Result: Inhibited the tumor growth by 80%.
Animal Model: Sepsis-induced acute lung injury rat model[6]
Dosage: 100 and 200 mg/kg
Administration: oral gavage,for 30 consecutive days
Result: Reduced the wet/dry ratio of lung tissue by 30.7% and 61.3%, and lipid peroxidation by 22.3% and 67%, at concentrations of 100 and 200mg/kg.
Reduced Inflammatory markers, neutrophils, lymphocytes and total cell count.
Reduced MPO activity.
Clinical Trial
CAS No.
Appearance

Solid

Color

Off-white to pink

SMILES

[Lactoferrin]
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Room temperature in continental US; may vary elsewhere.
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Sealed storage, away from moisture

Powder -80°C 2 years
-20°C 1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

H2O : ≥ 50 mg/mL

*"≥" means soluble, but saturation unknown.

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Lactoferrin Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Lactoferrin936541-36-5HSVHerpes simplex virusanti-inflammatoryimmunomodulatoryanti-cancerantiviralepithelial cellHaCaTcell adhesionInhibitorinhibitorinhibit

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