1. Immunology/Inflammation
  2. COX
  3. Parecoxib

Parecoxib (Synonyms: SC 69124)

Cat. No.: HY-17474 Purity: 99.32%
Handling Instructions

Parecoxib (SC 69124) is a highly selective and orally active COX-2 inhibitor, the prodrug of Valdecoxib (HY-15762). Parecoxib Sodium is a nonsteroidal anti-inflammatory agent (NSAID) and inhibits prostaglandin (PG) synthesis. Parecoxib can be used for the relief of acute postoperative pain and symptoms of chronic inflammatory conditions such as osteoarthritis and rheumatoid arthritis in vivo.

For research use only. We do not sell to patients.

Parecoxib Chemical Structure

Parecoxib Chemical Structure

CAS No. : 198470-84-7

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10 mM * 1 mL in DMSO USD 92 In-stock
Estimated Time of Arrival: December 31
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50 mg USD 144 In-stock
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100 mg USD 240 In-stock
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Based on 1 publication(s) in Google Scholar

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Description

Parecoxib (SC 69124) is a highly selective and orally active COX-2 inhibitor, the prodrug of Valdecoxib (HY-15762). Parecoxib Sodium is a nonsteroidal anti-inflammatory agent (NSAID) and inhibits prostaglandin (PG) synthesis. Parecoxib can be used for the relief of acute postoperative pain and symptoms of chronic inflammatory conditions such as osteoarthritis and rheumatoid arthritis in vivo[1][2].

IC50 & Target[1]

COX-2

 

In Vitro

Parecoxib (0-200 μM; 24-48 hours) inhibits the cell proliferation of GBM cells in a dose-dependent manner in GBM cells[4].
Parecoxib (200 μM; 24-48 hours) results in a decreasee migratory ability of U343 cells than PBS-treated group[4].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay[4]

Cell Line: GBM cells: U251 and U343 cells
Concentration: 0 μM, 20 μM, 50 μM, 100 μM and 200 μM
Incubation Time: 24-48 hours
Result: Resulted in a slower BrdU incorporation rate of GBM cells including U251 and U343 cells.
In Vivo

Parecoxib (intraperitoneal injection; 2.5, 5.0 or 10 mg/kg; once a day; 21 days) does not affect locomotor activity in the elevated plus-maze test, and Parecoxib at 5 and 10 mg/kg shows higher levels of percentage of time spent in the open arms[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Naive adult male ICR mice, 15 weeks old and weighing 25-35 g[3]
Dosage: 2.5, 5.0 or 10 mg/kg
Administration: Intraperitoneal injection; 2.5, 5.0 or 10 mg/kg; once a day; 21 days
Result: Exerted an anxiolytic-like effect in the elevated plus-maze test
Clinical Trial
Molecular Weight

370.42

Formula

C₁₉H₁₈N₂O₄S

CAS No.

198470-84-7

SMILES

CCC(NS(=O)(C1=CC=C(C2=C(C)ON=C2C3=CC=CC=C3)C=C1)=O)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : ≥ 50 mg/mL (134.98 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.6996 mL 13.4982 mL 26.9964 mL
5 mM 0.5399 mL 2.6996 mL 5.3993 mL
10 mM 0.2700 mL 1.3498 mL 2.6996 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (6.75 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (6.75 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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Keywords:

ParecoxibSC 69124SC69124SC-69124COXCyclooxygenaseosteoarthritisrheumatoid arthritispainchronic inflammatory conditioncoxibspostoperativecognitive dysfunctionPOCDanalgesiaInhibitorinhibitorinhibit

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Parecoxib
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HY-17474
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