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  5. Secoisolariciresinol diglucoside

Secoisolariciresinol diglucoside  (Synonyms: (S,S)-SDG; (S,S)-LGM2605)

Cat. No.: HY-105008 Purity: 99.85%
COA Handling Instructions

Secoisolariciresinol diglucoside ((S,S)-SDG), the main lignan in wholegrain flaxseed, is known for its beneficial effects including anti-inflammatory, antioxidant, anti-mutagenic, anti-microbial, anti-obesity, hypolipidemic, and neuroprotective effects.

For research use only. We do not sell to patients.

Secoisolariciresinol diglucoside Chemical Structure

Secoisolariciresinol diglucoside Chemical Structure

CAS No. : 257930-74-8

Size Price Stock Quantity
Solid + Solvent
10 mM * 1 mL in Water
ready for reconstitution
USD 145 In-stock
Solution
10 mM * 1 mL in Water USD 145 In-stock
Solid
5 mg USD 96 In-stock
10 mg USD 168 In-stock
25 mg USD 336 In-stock
50 mg USD 468 In-stock
100 mg USD 804 In-stock
200 mg   Get quote  
500 mg   Get quote  

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This product is a controlled substance and not for sale in your territory.

Customer Review

Based on 5 publication(s) in Google Scholar

Other Forms of Secoisolariciresinol diglucoside:

Top Publications Citing Use of Products

    Secoisolariciresinol diglucoside purchased from MedChemExpress. Usage Cited in: Mediat Inflamm. 2020 Jun 24;2020:3621261.  [Abstract]

    Representative immunoblots of cleaved caspase-3, Bcl-2, and Bax proteins in different groups.
    • Biological Activity

    • Purity & Documentation

    • References

    • Customer Review

    Description

    Secoisolariciresinol diglucoside ((S,S)-SDG), the main lignan in wholegrain flaxseed, is known for its beneficial effects including anti-inflammatory, antioxidant, anti-mutagenic, anti-microbial, anti-obesity, hypolipidemic, and neuroprotective effects[1][2].

    In Vitro

    Secoisolariciresinol diglucoside (1-500 μM) possesses strong reducing power and high free radical scavenging activity for hydroxyl, peroxyl and DPPH free radicals[1].
    Secoisolariciresinol diglucoside (1-50 μM; 24 h) attenuates human monocyte adhesion to and migration across human brain endothelial monolayers[2].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    In Vivo

    Secoisolariciresinol diglucoside (4 mg/mouse; a single p.o.) diminishes leukocyte adhesion and migration across blood-brain barrier (BBB) in neuroinflammation[2].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    Animal Model: Hand feeding mice (10 weeks old, male) are injected with TNFα[2]
    Dosage: 4 mg/mouse
    Administration: P.o. 2 h before i.c. administration of TNFα
    Result: Attenuated adhesion of leukocytes to the endothelium by 50% and attenuated migration of leukocytes across the BBB by 64%.
    Molecular Weight

    686.70

    Formula

    C32H46O16

    CAS No.
    Appearance

    Solid

    Color

    White to off-white

    SMILES

    COC1=C(O)C=CC(C[C@H](CO[C@@H]2O[C@@H]([C@@H](O)[C@H](O)[C@H]2O)CO)[C@](CO[C@@H]3O[C@@H]([C@@H](O)[C@H](O)[C@H]3O)CO)([H])CC4=CC(OC)=C(O)C=C4)=C1

    Structure Classification
    Initial Source
    Shipping

    Room temperature in continental US; may vary elsewhere.

    Storage
    Powder -20°C 3 years
    4°C 2 years
    In solvent -80°C 2 years
    -20°C 1 year
    Solvent & Solubility
    In Vitro: 

    H2O : ≥ 100 mg/mL (145.62 mM)

    *"≥" means soluble, but saturation unknown.

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 1.4562 mL 7.2812 mL 14.5624 mL
    5 mM 0.2912 mL 1.4562 mL 2.9125 mL
    View the Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

    * Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

    • Molarity Calculator

    • Dilution Calculator

    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

    Mass
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    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    This equation is commonly abbreviated as: C1V1 = C2V2

    Concentration (start)

    C1

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    Volume (start)

    V1

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    C2

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    In Vivo:

    For the following dissolution methods, please prepare the working solution directly. It is recommended to prepare fresh solutions and use them promptly within a short period of time.
    The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

    • Protocol 1

      Add each solvent one by one:  PBS

      Solubility: 50 mg/mL (72.81 mM); Clear solution; Need ultrasonic

    In Vivo Dissolution Calculator
    Please enter the basic information of animal experiments:

    Dosage

    mg/kg

    Animal weight
    (per animal)

    g

    Dosing volume
    (per animal)

    μL

    Number of animals

    Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
    Calculation results:
    Working solution concentration: mg/mL
    This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
    The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
    Purity & Documentation

    Purity: 99.85%

    References

    Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

    Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
    H2O 1 mM 1.4562 mL 7.2812 mL 14.5624 mL 36.4060 mL
    5 mM 0.2912 mL 1.4562 mL 2.9125 mL 7.2812 mL
    10 mM 0.1456 mL 0.7281 mL 1.4562 mL 3.6406 mL
    15 mM 0.0971 mL 0.4854 mL 0.9708 mL 2.4271 mL
    20 mM 0.0728 mL 0.3641 mL 0.7281 mL 1.8203 mL
    25 mM 0.0582 mL 0.2912 mL 0.5825 mL 1.4562 mL
    30 mM 0.0485 mL 0.2427 mL 0.4854 mL 1.2135 mL
    40 mM 0.0364 mL 0.1820 mL 0.3641 mL 0.9101 mL
    50 mM 0.0291 mL 0.1456 mL 0.2912 mL 0.7281 mL
    60 mM 0.0243 mL 0.1214 mL 0.2427 mL 0.6068 mL
    80 mM 0.0182 mL 0.0910 mL 0.1820 mL 0.4551 mL
    100 mM 0.0146 mL 0.0728 mL 0.1456 mL 0.3641 mL

    * Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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    Product Name:
    Secoisolariciresinol diglucoside
    Cat. No.:
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