1. Stem Cell/Wnt
    Immunology/Inflammation
    NF-κB
    Metabolic Enzyme/Protease
  2. Wnt
    Reactive Oxygen Species
  3. Echinacoside

Echinacoside 

Cat. No.: HY-N0020 Purity: 99.52%
Handling Instructions

Echinacoside, one of the phenylethanoids isolated from the stems of Cistanche salsa, effectively inhibits Wnt/β-catenin signaling. Echinacoside elicits neuroprotection by activating Trk receptors and their downstream signal pathways. Antiosteoporotic activity.

For research use only. We do not sell to patients.

Echinacoside Chemical Structure

Echinacoside Chemical Structure

CAS No. : 82854-37-3

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 83 In-stock
Estimated Time of Arrival: December 31
5 mg USD 72 In-stock
Estimated Time of Arrival: December 31
10 mg USD 96 In-stock
Estimated Time of Arrival: December 31
50 mg USD 324 In-stock
Estimated Time of Arrival: December 31
100 mg   Get quote  
200 mg   Get quote  

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Customer Review

Based on 4 publication(s) in Google Scholar

Top Publications Citing Use of Products

    Echinacoside purchased from MCE. Usage Cited in: Biochem Biophys Res Commun. 2020 Mar 19. pii: S0006-291X(20)30530-1. 

    Echinacoside inhibits the expression of key Wnt/b-catenin proteins in breast cancer cell lines. MDA-MB-231 and MDA-MB-468 cells are treated with the indicated concentrations of Echinacoside for 24 h. Cells are harvested, and proteins are extracted using RIPA cell lysis buffer.

    Echinacoside purchased from MCE. Usage Cited in: Biochem Biophys Res Commun. 2020 Mar 19. pii: S0006-291X(20)30530-1. 

    Echinacoside inhibits the expression of key Wnt/b-catenin proteins in breast cancer cell lines. MDA-MB-231 and MDA-MB-468 cells are treated with the indicated concentrations of Echinacoside for 24 h. LEF1, CD44, and cyclin D1 protein expression levels are detected by western blot.
    • Biological Activity

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    • References

    • Customer Review

    Description

    Echinacoside, one of the phenylethanoids isolated from the stems of Cistanche salsa, effectively inhibits Wnt/β-catenin signaling. Echinacoside elicits neuroprotection by activating Trk receptors and their downstream signal pathways. Antiosteoporotic activity[1][2][3].

    In Vivo

    Echinacoside (30-270 mg/kg body weight; p.o.; daily for 12 weeks) significantly reverses the increases of body weight, serum hydroxyproline (HOP) levels, and the decreases of uterus wet weight and bone mineral density (BMD) in In ovariectomized (OVX) rats[3].

    Animal Model: Fifty-six aged 6 months female Sprague-Dawley rats (OVX rat model)[3]
    Dosage: 30, 90, 270 mg/kg body weight
    Administration: p.o.; daily for 12 weeks
    Result: The increases of body weight, serum hydroxyproline (HOP) levels, and the decreases of uterus wet weight and BMD were significantly reversed.
    Molecular Weight

    786.73

    Formula

    C₃₅H₄₆O₂₀

    CAS No.

    82854-37-3

    SMILES
    Shipping

    Room temperature in continental US; may vary elsewhere.

    Storage
    Powder -20°C 3 years
      4°C 2 years
    In solvent -80°C 6 months
      -20°C 1 month
    Solvent & Solubility
    In Vitro: 

    DMSO : ≥ 100 mg/mL (127.11 mM)

    *"≥" means soluble, but saturation unknown.

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 1.2711 mL 6.3554 mL 12.7108 mL
    5 mM 0.2542 mL 1.2711 mL 2.5422 mL
    10 mM 0.1271 mL 0.6355 mL 1.2711 mL
    *Please refer to the solubility information to select the appropriate solvent.
    In Vivo:
    • 1.

      Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

      Solubility: ≥ 2.5 mg/mL (3.18 mM); Clear solution

    • 2.

      Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

      Solubility: ≥ 2.5 mg/mL (3.18 mM); Clear solution

    • 3.

      Add each solvent one by one:  10% DMSO    90% corn oil

      Solubility: ≥ 2.5 mg/mL (3.18 mM); Clear solution

    *All of the co-solvents are provided by MCE.
    References
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    Keywords:

    EchinacosideWntReactive Oxygen SpeciesInhibitorinhibitorinhibit

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    Product name:
    Echinacoside
    Cat. No.:
    HY-N0020
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