2. Metabolic Enzyme/Protease
  3. Aldose Reductase
  4. Poliumoside

Poliumoside, a caffeoylated phenylpropanoid glycoside, is isolated from Brandisia hancei stems and leaves. Poliumoside is an advanced glycation end product (AGE) formation and rat lens aldose reductase (RLAR) inhibitor, with IC50s of 19.69 and 8.47 μM, respectively. Poliumoside also has antiinflammatory and antioxidant activity.

For research use only. We do not sell to patients.

CAS No. : 94079-81-9

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Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
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Customer Review

Based on 8 publication(s) in Google Scholar

Other Forms of Poliumoside:

Poliumoside Related Antibodies

Top Publications Citing Use of Products

    Poliumoside purchased from MedChemExpress. Usage Cited in: Phytomedicine. 2024 Mar:125:155342.  [Abstract]

    Cell viability percentages post exposure to varied Poliumoside (Pol) (0, 5, 10, 20, 40, 80, 160 μM) concentrations over durations of 24/48 h.

    Poliumoside purchased from MedChemExpress. Usage Cited in: Phytomedicine. 2024 Mar:125:155342.  [Abstract]

    Imagery highlighting and corresponding quantification from DHE staining procedures treated with Poliumoside (Pol) (40 μM).

    Poliumoside purchased from MedChemExpress. Usage Cited in: Phytomedicine. 2024 Mar:125:155342.  [Abstract]

    Flow cytometry assessment illustrating MitoSox’s relative mean fluorescence intensity treated with Poliumoside (Pol) (40 μM).

    Poliumoside purchased from MedChemExpress. Usage Cited in: Phytomedicine. 2024 Mar:125:155342.  [Abstract]

    Protein expression levels of Opa1, Drp1, Mfn1, and Mfn2 as discerned via western blotting techniques treated with Poliumoside (Pol) (40 μM).

    Poliumoside purchased from MedChemExpress. Usage Cited in: Phytomedicine. 2024 Mar:125:155342.  [Abstract]

    Imagery from Nrf2 immunohistochemical staining focused on the thigh’s metaphyseal tissue treated with Poliumoside (Pol) (7.5, 15 mg/kg, i.p.)

    • Biological Activity

    • Purity & Documentation

    • References

    • Customer Review

    Description

    Poliumoside, a caffeoylated phenylpropanoid glycoside, is isolated from Brandisia hancei stems and leaves. Poliumoside is an advanced glycation end product (AGE) formation and rat lens aldose reductase (RLAR) inhibitor, with IC50s of 19.69 and 8.47 μM, respectively. Poliumoside also has antiinflammatory and antioxidant activity[1][2][3].

    IC50 & Target

    IC50: 8.47 μM (aldose reductase)[1]
    In Vitro

    Poliumoside inhibits AGE formation and RLAR, with IC50s of 19.69, and 8.47 μM, respectively[1].
    Poliumoside (5-30 μM; 3 h) inhibits AAPH-induced hemolysis of rat red blood cells in vitro[2].
    Poliumoside (12.5-100 μM; pretreated 2 h) inhibits the release of TNF-α and IL-6 in LPS-induced RAW 264.7 cells[3].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    Poliumoside Related Antibodies
    In Vivo

    Poliumoside inhibits vessel dilation in larval zebrafish[1].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
    Molecular Weight

    770.73

    Formula

    C35H46O19
    CAS No.
    Appearance

    Solid

    Color

    Light yellow to yellow

    SMILES

    OC1=C(O)C=CC(CCOC2C(C(OC3OC(C)C(O)C(O)C3O)C(OC(/C=C/C4=CC=C(O)C(O)=C4)=O)C(COC5OC(C)C(O)C(O)C5O)O2)O)=C1
    Structure Classification
    Initial Source
    Shipping

    Room temperature in continental US; may vary elsewhere.
    Storage
    Powder -20°C 3 years
    4°C 2 years
    In solvent -80°C 6 months
    -20°C 1 month
    Solvent & Solubility
    In Vitro: 

    DMSO : 100 mg/mL (129.75 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

    Ethanol : 50 mg/mL (64.87 mM; Need ultrasonic)

    H2O : 50 mg/mL (64.87 mM; Need ultrasonic)

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 1.2975 mL 6.4874 mL 12.9747 mL
    5 mM 0.2595 mL 1.2975 mL 2.5949 mL
    View the Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

    * Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

    • Molarity Calculator

    • Dilution Calculator

    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

    Mass
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    Concentration
    ×
    Volume
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    Molecular Weight *

    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    This equation is commonly abbreviated as: C1V1 = C2V2

    Concentration (start)

    C1

    ×
    Volume (start)

    V1

    =
    Concentration (final)

    C2

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    Volume (final)

    V2

    In Vivo:

    Select the appropriate dissolution method based on your experimental animal and administration route.

    For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
    To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
    The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

    • Protocol 1

      Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% Saline

      Solubility: ≥ 2.5 mg/mL (3.24 mM); Clear solution

      This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).

      Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.

      Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
    • Protocol 2

      Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in Saline)

      Solubility: ≥ 2.5 mg/mL (3.24 mM); Clear solution

      This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).

      Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.

      Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
    In Vivo Dissolution Calculator
    Please enter the basic information of animal experiments:

    Dosage

    mg/kg

    Animal weight
    (per animal)

    g

    Dosing volume
    (per animal)

    μL

    Number of animals

    Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
    Calculation results:
    Working solution concentration: mg/mL
    This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
    The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
    Purity & Documentation

    Purity: 99.69%

    SDS (251 KB)

    COA (255 KB) HNMR (147 KB) CNMR (137 KB) RP-HPLC (318 KB) MS (97 KB)

    Handling Instructions (2659 KB)
    References

    Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

    Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
    Ethanol / H2O / DMSO 1 mM 1.2975 mL 6.4874 mL 12.9747 mL 32.4368 mL
    5 mM 0.2595 mL 1.2975 mL 2.5949 mL 6.4874 mL
    10 mM 0.1297 mL 0.6487 mL 1.2975 mL 3.2437 mL
    15 mM 0.0865 mL 0.4325 mL 0.8650 mL 2.1625 mL
    20 mM 0.0649 mL 0.3244 mL 0.6487 mL 1.6218 mL
    25 mM 0.0519 mL 0.2595 mL 0.5190 mL 1.2975 mL
    30 mM 0.0432 mL 0.2162 mL 0.4325 mL 1.0812 mL
    40 mM 0.0324 mL 0.1622 mL 0.3244 mL 0.8109 mL
    50 mM 0.0259 mL 0.1297 mL 0.2595 mL 0.6487 mL
    60 mM 0.0216 mL 0.1081 mL 0.2162 mL 0.5406 mL
    DMSO 80 mM 0.0162 mL 0.0811 mL 0.1622 mL 0.4055 mL
    100 mM 0.0130 mL 0.0649 mL 0.1297 mL 0.3244 mL

    * Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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    Poliumoside Related Classifications

    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    Poliumoside94079-81-9Aldose ReductasecaffeoylatedphenylpropanoidglycosideBrandisiahanceiadvancedglycationendproductAGEaldosereductaseRLARantiinflammatoryantioxidantInhibitorinhibitorinhibit

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