1. Metabolic Enzyme/Protease
  2. Aldose Reductase
  3. Poliumoside

Poliumoside 

Cat. No.: HY-N0033 Purity: 95.64%
Handling Instructions

Poliumoside, a caffeoylated phenylpropanoid glycoside, is isolated from Brandisia hancei stems and leaves. Poliumoside is an advanced glycation end product (AGE) formation and rat lens aldose reductase (RLAR) inhibitor, with IC50s of 19.69 and 8.47 μM, respectively. Poliumoside also has antiinflammatory and antioxidant activity.

For research use only. We do not sell to patients.

Poliumoside Chemical Structure

Poliumoside Chemical Structure

CAS No. : 94079-81-9

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 238 In-stock
Estimated Time of Arrival: December 31
10 mg USD 216 In-stock
Estimated Time of Arrival: December 31
50 mg USD 670 In-stock
Estimated Time of Arrival: December 31
100 mg USD 1070 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

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Description

Poliumoside, a caffeoylated phenylpropanoid glycoside, is isolated from Brandisia hancei stems and leaves. Poliumoside is an advanced glycation end product (AGE) formation and rat lens aldose reductase (RLAR) inhibitor, with IC50s of 19.69 and 8.47 μM, respectively. Poliumoside also has antiinflammatory and antioxidant activity[1][2][3].

IC50 & Target

IC50: 8.47 μM (aldose reductase)[1]

In Vitro

Poliumoside inhibits AGE formation and RLAR, with IC50s of 19.69, and 8.47 μM, respectively[1].
Poliumoside (5-30 μM; 3 h) inhibits AAPH-induced hemolysis of rat red blood cells in vitro[2].
Poliumoside (12.5-100 μM; pretreated 2 h) inhibits the release of TNF-α and IL-6 in LPS-induced RAW 264.7 cells[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Poliumoside inhibits vessel dilation in larval zebrafish[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

770.73

Formula

C₃₅H₄₆O₁₉

CAS No.
SMILES

OC1=C(O)C=CC(CCOC2C(C(OC3OC(C)C(O)C(O)C3O)C(OC(/C=C/C4=CC=C(O)C(O)=C4)=O)C(COC5OC(C)C(O)C(O)C5O)O2)O)=C1

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (129.75 mM; Need ultrasonic)

Ethanol : 50 mg/mL (64.87 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.2975 mL 6.4874 mL 12.9747 mL
5 mM 0.2595 mL 1.2975 mL 2.5949 mL
10 mM 0.1297 mL 0.6487 mL 1.2975 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (3.24 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.5 mg/mL (3.24 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (3.24 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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  • Molarity Calculator

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Keywords:

PoliumosideAldose ReductasecaffeoylatedphenylpropanoidglycosideBrandisiahanceiadvancedglycationendproductAGEaldosereductaseRLARantiinflammatoryantioxidantInhibitorinhibitorinhibit

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Product Name:
Poliumoside
Cat. No.:
HY-N0033
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